Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis

Devareddy, Latha; Khalil, Dania A.; Smith, Brenda J.; Lucas, Edralin A.; Soung, Do Y.; Marlow, Denver; Arjmandi, Bahram H.

doi:10.1016/j.bone.2005.10.024

Cited by 78 publications

(66 citation statements)

References 59 publications

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“…54 A similar result was also found in the study by Devareddy et al, where soy protein-enriched SI positively affected tibial architectural properties in the OVX rat model, including trabecular thickness, trabecular separation, and trabecular number. 55 Furthermore, OVX rats fed with soy protein had a lower body weight and Dpd concentration, 56 whereas those fed with soy protein enriched with a high-dose SI showed statistically significant positive change in bone mass and turnover markers. 57 Thus, soy protein might enhance the ability of SI by transforming them into a more potent beneficial effective form (e.g., equol).…”

Section: Intervention Materialsmentioning

confidence: 99%

Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling

Zheng

Lee

Chun

2016

Journal of Medicinal Food

130

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Osteoporosis is an age-related disorder that affects both women and men, although estrogen deficiency induced by menopause accelerates bone loss in older women. As the demographic shifts to a more aged population, a growing number of men and women will be afflicted with osteoporosis. Since the current drug therapies available have multiple side effects, including increased risk of developing certain types of cancer or complications, a search for potential nonpharmacologic alternative therapies for osteoporosis is of prime interest. Soy isoflavones (SI) have demonstrated potential bone-specific effects in a number of studies. This article provides a systematic review of studies on osteoporotic bone loss in relation to SI intake from diet or supplements to comprehensively explain how SI affect the modulation of bone remodeling. Evidence from epidemiologic studies supports that dietary SI attenuate menopause-induced osteoporotic bone loss by decreasing bone resorption and stimulating bone formation. Other studies have also illustrated that bone site-specific trophic and synergistic effects combined with exercise intervention might contribute to improve the bioavailability of SI or strengthen the bonespecific effects. To date, however, the effects of dietary SI on osteoporotic bone loss remain inconclusive, and study results vary from study to study. The current review will discuss the potential factors that result in the conflicting outcomes of these studies, including dosages, intervention materials, study duration, race, and genetic differences. Further well-designed studies are needed to fully understand the underlying mechanism and evaluate the effects of SI on osteoporosis in humans.

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Section: Intervention Materialsmentioning

confidence: 99%

Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling

Zheng

Lee

Chun

2016

Journal of Medicinal Food

130

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“…Although the exact mechanisms by which OVX increases body weight are not clear, a recent study reported that an estrogendeficient state induced body fat accumulation and increased body weight [29]. OVX-rats show increased body weight compared to sham-operated rats while E2 treatment prevents body weight gain [30]. Estrogen deficiency induces body fat accumulation and subsequently increases body weight [29].Estrogen acts by binding to different ERs (ERα and ERβ).…”

Section: Discussionmentioning

confidence: 99%

Bone regenerative effect of aqueous Cynanchum wilfordii extract in receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation and estrogen deficiency-induced osteoporosis

Jun

Choi

Lee

et al. 2017

ijpm

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A b s t r a c tOsteoporosis increases with age, most frequently in postmenopausal women because of reduced ovarian hormone levels. Furthermore, estrogen deficiency impairs trabecular metaphyseal bone. Although estrogen herbal therapies maybe safer alternatives. Therefore, the aim of this study the effects of aqueous extracts factor mediated osteoporosis tartrate cells. We investigated the osteoprotective effect of CWW in an ovariectomized (OVX) Sprague Dawley rat model doses (100, 200, and 400 mg/kg). After a 24 were not affected except in the OVX/E2 group. Additionally, bone mineral density (BMD) and histological analyses significantly higher group rats. collagen type I C results show that compar the OVX model. Taken together, CWW exhibited inhibitory effects on osteoclastogenesis vitro,

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“…Todo esto sugiere que los mecanismos por los cuales actúa la soja son diferentes a los mecanismos hormonales. Incluso existen trabajos en modelos animales que han demostrado una mejoría en la microestructura ósea tras la suplementación con soja sin conseguir aumentar la masa ósea (15).…”

Section: Evidencias Científicas De La Relación Soja Prevención De Ostunclassified

Influencia del consumo de soja sobre la masa ósea

Luis

Castrillón

Aller

et al. 2007

An. Med. Interna (Madrid)

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Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis

Cited by 78 publications

References 59 publications

Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling

Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling

Bone regenerative effect of aqueous Cynanchum wilfordii extract in receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation and estrogen deficiency-induced osteoporosis

Influencia del consumo de soja sobre la masa ósea

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