Soy Protein Isolates of Varied Isoflavone Content Do Not Influence Serum Thyroid Hormones in Healthy Young Men

Dillingham, Barbara L.; McVeigh, Brianne L.; Lampe, Johanna W.; Duncan, Alison

doi:10.1089/thy.2006.0206

Cited by 42 publications

(21 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among vegetarians with subclinical hypothyroidism, soy phytoestrogens may impair thyroid status [26]. On the other hand, most human clinical data do not show a significant causative effect of soy on hypothyroidism [27,28]. Goitergenic foods include cruciferous vegetables which suppress thyroid function, however, little evidence exists that these effects are clinically significant in the U.S. population.…”

Section: Discussionmentioning

confidence: 99%

Vegan Diets and Hypothyroidism

et al. 2013

View full text Add to dashboard Cite

Diets eliminating animal products have rarely been associated with hypothyroidism but may protect against autoimmune disease. Thus, we investigated whether risk of hypothyroidism was associated with vegetarian compared to omnivorous dietary patterns. The Adventist Health Study-2 was conducted among church members in North America who provided data in a self-administered questionnaire. Hypothyroidism was queried at baseline in 2002 and at follow-up to 2008. Diet was examined as a determinant of prevalent (n = 4237 of 65,981 [6.4%]) and incident cases (1184 of 41,212 [2.9%]) in multivariate logistic regression models, controlled for demographics and salt use. In the prevalence study, in addition to demographic characterstics, overweight and obesity increased the odds (OR 1.32, 95% CI: 1.22–1.42 and 1.78, 95% CI: 1.64–1.93, respectively). Vegan versus omnivorous diets tended to be associated with reduced risk (OR 0.89, 95% CI: 0.78–1.01, not statistically significant) while a lacto-ovo diet was associated with increased risk (OR 1.09, 95% CI: 1.01–1.18). In the incidence study, female gender, white ethnicity, higher education and BMI were predictors of hypothyroidism. Following a vegan diet tended to be protective (OR 0.78, 95% CI: 0.59–1.03, not statistically significant). In conclusion, a vegan diet tended to be associated with lower, not higher, risk of hypothyroid disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Vegan Diets and Hypothyroidism

et al. 2013

View full text Add to dashboard Cite

show abstract

“…4 In addition, we found no evidence that soy foods negatively affected serum TSH or thyroxine concentrations, consistent with essentially all data on this subject. 62 The significant decline in TSH in the AF group may have indicated an improvement in thyroid hormone status, perhaps because of the increased consumption of dairy products, a good source of dietary iodine in the United States. 63 …”

Section: Soy Food Intake and Mineral Status 777mentioning

confidence: 99%

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

Zhou¹,

Alekel²,

Dixon

et al. 2011

Journal of Women's Health

View full text Add to dashboard Cite

Background: Soy foods have been substituted for meat in recent years because of proposed health benefits. Research indicates, however, that soy protein and phytate in soy products inhibit the absorption of divalent cations. Methods: Our study was primarily designed to determine the effect of consuming two to three servings per day of soy foods, providing *19 g protein and *36 mg isoflavones, on iron and zinc status in premenopausal women during a 10-weeks period. As secondary outcomes, we also tested the effect of soy foods on biochemical markers of bone and thyroid hormones. Nonsmoking women (18-28 years) without chronic disease, anemia, pregnancy, or irregular menstrual cycles were randomly assigned to either the soy food (SF, n = 31) or animal food (AF, n = 32) group. Blood and urine samples and 3-day dietary records were collected at baseline and postintervention. Results: At baseline, iron and zinc status, bone markers, and thyroid hormones were not different between groups. After intervention, no significant changes were observed in hemoglobin, transferrin saturation, serum iron, ferritin, or transferrin receptor (TFR) concentrations. Plasma zinc, but not serum alkaline phosphatase, significantly decreased in both groups ( -0.8 lmol/L).

show abstract

“…Affecting thyroid hormone: high risk soy-diet may affect thyroid hormone levels through stimulating thyrotropin, however this effect do not cause too much changes in T3 (triiodothyronine) and T4 (thyroxine) in human (Dillingham et al, 2007). Isoflavone can competitively bind to thyroid peroxidase, which converts T3 to T4 (Doerge and Chang, 2002).…”

Section: Hormone-like Propertiesmentioning

confidence: 99%