Soy protein may alleviate osteoarthritis symptoms

Arjmandi, Bahram H.; Khalil, Dania A.; Lucas, Edralin A.; Smith, Brenda J.; Sinichi, N.; Hodges, Stephanie; Juma, Shanil; Munson, Mark E.; Payton, Mark E.; Tivis, Rick; Svanborg, A

doi:10.1016/j.phymed.2003.11.001

Cited by 71 publications

(64 citation statements)

References 29 publications

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“…Notably, some components of soy have great potential in OA control. It has been demonstrated (Arjmandi et al, 2004) that 40 g of supplemental soy protein daily for 3 months improved OA-associated symptoms, such as range of motion and several factors associated with pain and quality of life, in comparison to same dosage of milk-based protein. Furthermore, biochemical markers of cartilage metabolism further supported the efficacy of soy protein supplementation in relieving symptoms of OA as indicated by a significant increase in serum level of insulin-like growth factor-I, a growth factor associated with cartilage synthesis, and a significant decrease in serum level of glycoprotein 39, a marker of cartilage degradation (Arjmandi et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated (Arjmandi et al, 2004) that 40 g of supplemental soy protein daily for 3 months improved OA-associated symptoms, such as range of motion and several factors associated with pain and quality of life, in comparison to same dosage of milk-based protein. Furthermore, biochemical markers of cartilage metabolism further supported the efficacy of soy protein supplementation in relieving symptoms of OA as indicated by a significant increase in serum level of insulin-like growth factor-I, a growth factor associated with cartilage synthesis, and a significant decrease in serum level of glycoprotein 39, a marker of cartilage degradation (Arjmandi et al, 2004). Besides, avocado/soybean unsaponifiables (ASU), a new antiarthritic agent derived from unsaponifiable residues of avocado and soybean oils mixed in the ratio of 1:2 respectively, has also been recommended for treat -ing OA with published basic and clinical trials in animals and humans (Maheu et al, 1998;Appelboom et al, 2001;Kut-Lasserre et al, 2001;Henrotin et al, 2003), thus considered a symptomatic disease-modifying osteo -arthritic compound (Lippiello et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

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Effect of semen sojae germinatum on experimental osteoarthritis in the rabbit knee

Wang

2013

Bangladesh J Pharmacol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of semen sojae germinatum on experimental osteoarthritis in the rabbit knee

Wang

2013

Bangladesh J Pharmacol

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“…It has been shown that genistein can bind to estrogen receptors (ERs) with an affinity 100 to 1000-fold less than that of estradiol and that it competes with estradiol and displaces it from its binding sites [13] . A clinical study has suggested that consuming 88 mg phytoestrogen per day may benefit OA patients [14] . Hooshmand et al have also reported that genistein reduced the in vitro production of lipopolysaccharide-induced cyclooxygenase (COX)-2 in chondrocytes, indicating that genistein may be an attractive and viable alternative therapy for treating or preventing OA [15] .…”

Section: Introductionmentioning

confidence: 99%

Excess genistein suppresses the synthesis of extracellular matrix in female rat mandibular condylar cartilage

Xing

Dong

et al. 2012

Acta Pharmacol Sin

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Aim:To investigate the effect of excess genistein on the extracellular matrix in mandibular condylar cartilage of female rats in vivo. Methods: Female SD rats were administered through oral gavage with genistein (50 mg/kg) or placebo daily for 6 weeks. The morphological changes of temporomandibular joints were studied with HE staining. The expression of cartilage matrix compounds (aggrecan and collagen type II), estrogen-related molecules (aromatase, estradiol, ERα and ERβ) and proliferating cell nuclear antigen (PCNA) in mandibular condylar cartilage was detected using immunohistochemistry, ELISA and real-time PCR. Results: The genistein treatment significantly reduced the thickness of the posterior and middle regions of mandibular condylar cartilage, and decreased the expression of collagen type II, aggrecan and PCNA. Compared with the control group, the estradiol content and expression levels of the key estradiol-synthesizing enzyme aromatase in the genistein-treatment group were significantly decreased. The genistein treatment significantly increased the expression of ERβ, but decreased the expression of ERα. Conclusion: Excess genistein suppresses extracellular matrix synthesis and chondrocytes proliferation, resulting in thinner mandibular condylar cartilage. These effects may be detrimental to the ability of mandibular condylar cartilage to adapt to mechanical loads.

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“…It is thought that the degenerative changes are accompanied by a local inflammatory component that accelerates the joint destruction [13]. OA is the most common joint disease in the elderly causing major orthopedic problems [14] and contributing to disability [15].…”

Section: Introductionmentioning

confidence: 99%

“…OA is the most common joint disease in the elderly causing major orthopedic problems [14] and contributing to disability [15]. Recently, Arjmandi et al [13] have evaluated the efficacy of soy protein (SP) supplementation in relieving the pain and discomfort associated with OA. Overall, the study showed that SP improved OA-associated symptoms, particularly in men.…”

Section: Introductionmentioning

confidence: 99%

Micro‐high‐performance liquid chromatography platform for the depletion of high‐abundance proteins and subsequent on‐line concentration/capturing of medium and low‐abundance proteins from serum. Application to profiling of protein expression in healthy and osteoarthritis sera by 2‐D gel electrophoresis

Jmeian

Rassi

2008

Electrophoresis

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In this investigation, an integrated microcolumn-based fluidic platform for the simultaneous depletion of high-abundance proteins and the subsequent on-line concentration/capturing of medium- and low-abundance proteins from human serum has been introduced. The platform consists of on-line coupling of tandem affinity micorcolumns to an RP microcolumn to achieve first the depletion of high-abundance proteins by the tandem affinity microcolumns followed by the concentration and capturing of medium- and low-abundance proteins by the RP microcolumn. The tandem affinity microcolumns are based on macroporous monoliths characterized by their relatively high permeability in pressure-driven flow while the RP microcolumn is packed with polymeric particles with an average particle diameter of 20 microm giving rise to a very little back pressure, thus allowing fast flow velocity across the coupled columns format and consequently short processing time of serum samples prior to analysis by 2-DE. The microcolumn-based fluidic platform was applied to serum samples from osteoarthritis (OA) donors before and after soy protein (SP) supplementation, and from healthy donors, and the resulting depleted serum samples from high-abundance proteins were profiled for protein expression by 2-DE. In general, the protein expression was lower in serum of the same OA patient after soy treatment than before soy treatment. Several proteins were down-regulated after soy treatment with transthyretin being the most affected by the SP supplementation. In addition, with respect to serum from healthy donors, the sera from OA patients showed difference in proteins expression.

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Soy protein may alleviate osteoarthritis symptoms

Cited by 71 publications

References 29 publications

Effect of semen sojae germinatum on experimental osteoarthritis in the rabbit knee

Effect of semen sojae germinatum on experimental osteoarthritis in the rabbit knee

Excess genistein suppresses the synthesis of extracellular matrix in female rat mandibular condylar cartilage

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