Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints

Abstract

Soybean-derived phosphatidylserine (Soy-PS) is a phosphatidylserine made from soybean lecithin by enzymatic reaction with L-serine. A double-blind, randomized controlled study was conducted to investigate the effects of Soy-PS on the cognitive functions of the elderly Japanese subjects with memory complaints. Seventy-eight elderly people with mild cognitive impairment (50–69 years old) were randomly allocated to take Soy-PS (100 mg, 300 mg/day) or placebo for 6 months. As a result, there was no difference in blood markers and vital signs during Soy-PS treatment and any side effect caused by Soy-PS treatment was not observed. Neuropsychological test scores were similarly increased in all groups including placebo group. However, in the subjects with relatively low score at baseline, the memory scores in PS treated groups were significantly increased against the baseline, while those of placebo group remained unchanged. And the memory improvements in Soy-PS-treated groups were mostly attributed to the increase in delayed verbal recall, a memory ability attenuated in the earliest stage of dementia. In conclusion, Soy-PS used in this study is considered as safety food ingredient and 6 months of Soy-PS supplementation could improve the memory functions of the elderly with memory complaints.

Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health

“…Kato-Kataoka et al [43] conducted a similar double-blind, randomized study on 78 subjects (50 -69 years old) to determine if 100 -300 mg oral PS per day versus placebo affected memory scores. They found that PS significantly improved behavioral memory functions, especially short-term memory and cognitive function in low-scoring (delayed word recall) participants (p < 0.01) [43].…”

The effect of physical activity, pharmacologic interventions, over-the-counter supplements and cognitive training in preventing Alzheimer’s disease, mild cognitive impairment and related dementias: an overview

“…Da ly viai buvo su skirs ty ti á tris gru pes, ku riø kiek vie na kas dien var to jo pla ce bà ar ba 100/300 mg ið so jø pu pe liø ið gau tà fos fa ti dilse ri nà. Pa ly gi nus vi sø ti ria mø jø gru piø kog ni ty vi niø tes tø re zul ta tus po 9 ty ri mø më ne siø, reikð min gø skir tu mø tarp gru piø ne ras ta [47].…”

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“…However, many reports have shown cognitive improvement. The most recent study of PS was a double-blind, placebo-controlled trial in elderly Japanese patients with mild memory impairment [7]. The participants were prescribed Soy-PS or placebo in dosages of 100 mg or 300 mg per day for 6 months.…”