2008
DOI: 10.1211/jpp.60.4.0008
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Soybean fat supplementation controls insulin resistance caused by fat-free total parenteral nutrition

Abstract: Conscious young adult male rats were given total parenteral nutrition (TPN) with or without soybean fat for 4 days. Those given fat-free TPN developed severe fatty liver, with hyperglycaemia, hyperinsulinaemia, and hypotriglyceridaemia. These disorders were clearly improved by supplementing TPN with soybean fat, in an amount equivalent to 20% of total calories, and correspondingly reducing glucose. Insulin resistance also developed over a 4-day infusion of fat-free TPN in mature rats. Even after over-night fas… Show more

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Cited by 5 publications
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“…Replacement of 20% of the carbohydrate calories with fat in a rat PN model resulted in normalized serum glucose, lower serum insulin, and improvements in insulin resistance as measured by the HOMA-IR index compared with groups administered isocaloric fat-free PN (15). These studies highlight the important contribution of intravenous lipid emulsions to meeting nutritional requirements in PN.…”
Section: Nutritional Fat Requirementsmentioning
confidence: 70%
“…Replacement of 20% of the carbohydrate calories with fat in a rat PN model resulted in normalized serum glucose, lower serum insulin, and improvements in insulin resistance as measured by the HOMA-IR index compared with groups administered isocaloric fat-free PN (15). These studies highlight the important contribution of intravenous lipid emulsions to meeting nutritional requirements in PN.…”
Section: Nutritional Fat Requirementsmentioning
confidence: 70%