Soybean-fragmented proteoglycans against skin aging

Abstract

A beneficial effect of the Proteum serum was demonstrated with an improvement in the skin roughness and a reinforcement of the skin barrier function. Moreover, a significant protector effect on human stratum corneum against lipids peroxides (LPO) was demonstrated.

Antiaging effects of a novel facial serum containing L-ascorbic acid, proteoglycans, and proteoglycan-stimulating tripeptide: ex vivo skin explant studies and in vivo clinical studies in women

“…Earlier published reports suggest that proteoglycan synthesis can be stimulated by the application of certain topical peptides (such as copper peptide and carnosine), 18 but to our knowledge, the effects of the particular peptide in the tested product (tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate) have not been published. Barba et al 19 have reported the effects of a serum containing fragmented proteoglycans from soybeans on collagen and proteoglycan levels in vitro, although their results are not directly comparable to ours due to differences in methodology. Our study was a comparison of aged and serum-treated skin against aged untreated skin and nonaged skin, and we found that levels in serum-treated samples were close to those of healthy, nonaged skin.…”

High global antioxidant protection and stimulation of the collagen synthesis of new anti‐aging product containing an optimized active mix

“…Skin aging results in a thinner and less well‐protected skin 13,14 . It is caused by a combination of genetic factors and exposome factors (environmental and biological factors) on top of chronological aging 15 .…”

“…They are composed of amino acids, and they can imitate peptide sequences or act as messenger molecules stimulating the production of collagen, elastin, and lumican rebuilding the dermal matrix, reducing the appearance of wrinkles and to increase firmness 21–24 . Collagen (COL) is the major ECM molecule in the dermis, along with other components that confer properties on the skin 14 25 …”

“… 21 , 22 , 23 , 24 Collagen (COL) is the major ECM molecule in the dermis, along with other components that confer properties on the skin. 14 The main ones are I, III, VI, and XIV (dermis), IV (basal membranes), VII and XVII (epidermis‐dermis junctions), XIII (epidermis), and XV and XVI (fibroblasts). 25…”

“…PC, sodium ascorbate (0.01%); SD, standard deviation Skin aging results in a thinner and less well-protected skin. 13,14 It is caused by a combination of genetic factors and exposome factors (environmental and biological factors) on top of chronological aging. 15 Due to modern urban life, the population is exposed on a daily basis to solar radiation and other external factors including air pollution, tobacco smoke, stress, or solar radiation.…”