Soybean (Glycine max) allergy in Europe: Gly m 5 (β-conglycinin) and Gly m 6 (glycinin) are potential diagnostic markers for severe allergic reactions to soy

Abstract

Sensitization to the soybean allergens Gly m 5 or Gly m 6 is potentially indicative for severe allergic reactions to soy.

Soybean Allergens Affecting North American Patients Identified by 2D Gels and Mass Spectrometry

“…While several studies have shown that IgE from soysensitive patients react primarily to the glycinin and β-conglycinin fractions (Holzhauser et al 2009;Ogawa et al 1995), we have shown in this study that a high percentage of patient IgE also reacts to non-storage proteins, including a seed maturation protein known as LEA protein. In fact, two patients in this cohort had an IgE reaction only to LEA protein (Figs.…”

“…These three subjects share a common IgE reaction against both the α subunit of β-conglycinin (#3) and the A2 subunit of glycinin (#10) (see Table 3). Holzhauser et al (2009) have recently shown that these two allergens, Gly m 5 (β-conglycinin) and Gly m 6 (glycinin), were potentially indicative for severe allergic reactions to soy in a European adult cohort. Most of the individual's serum in our study recognized between four and six soybean proteins at varying intensities.…”

Clinical relevance of IgE to recombinant Gly m 4 in the diagnosis of adult soybean allergy

“…Soybean is one of the most important foods causing food allergy in childhood 1 . In addition, studies have shown that allergy to soybean can be caused by IgE crossreactivity between Bet v 1, a major allergen of birch pollen, and its homologue pathogenesis-related class 10 (PR-10) protein in soybean, Gly m 4 2,3 .…”

High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China

“…Soy allergy conventionally is characterized by IgE sensitization to storage proteins like Gly m 5, Gly m 6 (Holzhauser et al, 2009;Ito et al, 2011), or Gly m 8 that are 2S albumins (Ebisawa et al, 2013). The association between birch and soy allergy was first reported by Kleine-Tebbe et al (2002) describing that patients with birch pollen allergy had allergic reactions to a soy-containing dietary product.…”