Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Zhang, Jian; Li, Wenhui; Ying, Zhiwei; Zhao, Di; Yi, Guofu; He, Li; Liu, Xinqi

doi:10.29219/fnr.v64.3677

Cited by 26 publications

(15 citation statements)

References 47 publications

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“…SPs currently in market have diverse applications such as in sports drinks, meal replacements, diet meals, and health supplements. SP material market has recently been experiencing rapid global growth as consumers have become increasingly aware of the benefits of soy peptides, including its nutritional and physiological effects, effects on physical fatigue related to absorption rate and sports nutrition, and effect on psychological fatigue related to stress [10,151,155]. In particular, the main attraction of products containing SPs currently available in market is fatigue recovery.…”

Section: Economic Feasibility and Application Of Soybean-derived Bioactive Peptidesmentioning

confidence: 99%

Beneficial Effects of Soybean-Derived Bioactive Peptides

Kim

Yang²,

Kim

2021

IJMS

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Peptides present in foods are involved in nutritional functions by supplying amino acids; sensory functions related to taste or solubility, emulsification, etc.; and bioregulatory functions in various physiological activities. In particular, peptides have a wide range of physiological functions, including as anticancer agents and in lowering blood pressure and serum cholesterol levels, enhancing immunity, and promoting calcium absorption. Soy protein can be partially hydrolyzed enzymatically to physiologically active soy (or soybean) peptides (SPs), which not only exert physiological functions but also help amino acid absorption in the body and reduce bitterness by hydrolyzing hydrophobic amino acids from the C- or N-terminus of soy proteins. They also possess significant gel-forming, emulsifying, and foaming abilities. SPs are expected to be able to prevent and treat atherosclerosis by inhibiting the reabsorption of bile acids in the digestive system, thereby reducing blood cholesterol, low-density lipoprotein, and fat levels. In addition, soy contains blood pressure-lowering peptides that inhibit angiotensin-I converting enzyme activity and antithrombotic peptides that inhibit platelet aggregation, as well as anticancer, antioxidative, antimicrobial, immunoregulatory, opiate-like, hypocholesterolemic, and antihypertensive activities. In animal models, neuroprotective and cognitive capacity as well as cardiovascular activity have been reported. SPs also inhibit chronic kidney disease and tumor cell growth by regulating the expression of genes associated with apoptosis, inflammation, cell cycle arrest, invasion, and metastasis. Recently, various functions of soybeans, including their physiologically active functions, have been applied to health-oriented foods, functional foods, pharmaceuticals, and cosmetics. This review introduces some current results on the role of bioactive peptides found in soybeans related to health functions.

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Section: Economic Feasibility and Application Of Soybean-derived Bioactive Peptidesmentioning

confidence: 99%

Beneficial Effects of Soybean-Derived Bioactive Peptides

Kim

Yang²,

Kim

2021

IJMS

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“…Liver is a dynamic organ in serum protein synthesis, gluconeogenesis, lipogenesis, and cholesterol metabolism ( 28 ). Serum TP and ALB are regarded as the important indicators of the protein metabolism, and decreased serum TP and ALB concentrations is usually related to malnutrition and growth retardation in animals ( 29 , 30 ). The serum level of GLU is an indicator of glycolipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…Song et al ( 40 ) found that supplementation of aureomycin reduced serum concentrations of TNF-α, IL-2, and IL-6 in broiler chickens. The immune response is controlled by the complex interaction of various cytokines, and pro-inflammatory factors IL-6 and IL-1β have been used as markers of the inflammatory response ( 29 ). IL-1β plays a decisive role in the production of pro-inflammatory and homeostatic functions ( 41 ), while IL-6 is a multifunctional cytokine that can participate in the regulation of body inflammation, hematopoiesis, immune response, and acute phase response ( 42 , 43 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Macleaya cordata Extract Containing Isoquinoline Alkaloids Supplementation as an Alternative to Antibiotics in the Diets on Growth Performance and Liver Health of Broiler Chickens

Liu

Niu

et al. 2022

Front. Vet. Sci.

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This study aimed to investigate the effects of dietary supplementation with Macleaya cordata extract (MCE) containing protopine and allotypotopine on the growth performance and liver health in broiler chickens. A total of 486 1-day-old male AA broiler chickens were randomly assigned to the following three groups: (1) control (CON) group, broiler chickens fed a basal diet; (2) AGP group (positive control), broiler chickens fed a basal diet supplemented with 50 mg/kg aureomycin; (3) MCE group, broiler chickens fed a basal diet supplemented with 0.6 mg/kg MCE including 0.4 mg/kg protopine and 0.2 mg/kg allotypotopine. The results showed that the MCE group had significantly higher final body weight and average daily gain from d 0 to 42 than the other groups (p < 0.05), and groups MCE and AGP both had significantly lower feed-to-gain ratio from d 0 to 42 than the CON group (p < 0.05). Serum total protein, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, glucose, immunoglobulin A, immunoglobulin M, and complements (C3, C4) concentrations in the MCE group were significantly higher than in the CON group (p < 0.05). Dietary MCE or aureomycin supplementation significantly reduced the hepatic contents of 8-hydroxy-2'-deoxyguanosine, malondialdehyde, interleukin (IL)-1β, IL-6, NLRs family pyrin domain containing 3 (NLRP3), and caspase-1 in the liver (p < 0.05). Moreover, MCE or aureomycin supplementation significantly inhibited mRNA expressions of Toll-like receptor 4, myeloid differentiation factor 88, nuclear factor-κB, and NLRP3, as well as the expression ratio of Bax to Bcl-2 mRNA (p < 0.05). Therefore, our study suggested that dietary supplementation with 0.6 mg/kg MCE containing protopine and allocryptopine improved growth performance and benefited liver health in broiler chickens possibly through inhibiting caspase-1-induced pyroptosis by inactivating TLR4/MyD88/NF-κB/NLRP3 signaling pathway, and provided support for the application of MCE containing protopine and allocryptopine as an alternative to antibiotics in the feed industry.

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“…The molecular weight distribution of Se‐SPep was determined following a previously reported method (Zhang, Li, et al., 2020 ). The standard molecular weight samples containing aprotinin (6500 Da), bacitracin (1422 Da), and Gly–Gly–Tyr–Arg (451 Da) were passed through 0.22 μm filters and successively loaded into a Superdex 200 10/300 GL column.…”

Section: Methodsmentioning

confidence: 99%