Sp1-induced LncRNA CTBP1-AS2 is a novel regulator in cardiomyocyte hypertrophy by interacting with FUS to stabilize TLR4

Luo, Xiaojia; He, Sen; Hu, Yongmei; Liu, Jianxiong; Chen, Xiaoping

doi:10.1016/j.carpath.2019.04.005

Cited by 36 publications

(27 citation statements)

References 30 publications

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“…Previous studies have reported the involvement of CTBP1-AS2 in type 2 diabetes and cardiomyocyte hypertrophy [12,13]. Decreased expression level of CTBP1-AS2 was closely correlated with the occurrence of type 2 diabetes and cardiomyocyte hypertrophy among Iranian population [12]., Luo et al reported that CTBP1-AS2 could be induced by Sp1 and it could stabilize TLR4 through the interaction with FUS to participate in the disease progression [13]. Our study is the first to report the involvement of CTBP1-AS2 in cancer biology.…”

Section: Discussionmentioning

confidence: 99%

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RETRACTED ARTICLE: LncRNA CTBP1-AS2 sponges miR-216a to upregulate PTEN and suppress endometrial cancer cell invasion and migration

2020

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Background: Although lncRNA CTBP1-AS2 has been functionally analyzed only in cardiomyocyte hypertrophy and diabetes, analysis of TCGA dataset revealed its downregulation in endometrial carcinoma (EC), indicating its involvement in EC. Results: In this study we found that CTBP1-AS2 was downregulated in EC and correlated with poor survival. MiR-216a might form base pairs with CTBP1-AS2 based on RNA-RNA interaction, which was confirmed by luciferase activity assay. Interestingly, upregulation of PTEN was observed after CTBP1-AS2 overexpression. Transwell assay showed that CTBP1-AS2 and PTEN overexpression led to decreased cancer cell invasion and migration and reduced enhancing effects of miR-216a on cell invasion and migration. It was known that miR-216a targeted PTEN. Conclusion: Therefore, CTBP1-AS2 may sponge miR-216a to upregulate PTEN, thereby suppressing endometrial cancer cell invasion and migration.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, regulating the expression of cancer-related lncRNAs will also contribute to cancer treatment. CTBP1-AS2 has been characterized as a critical player in type 2 diabetes and cardiomyocyte hypertrophy [12,13]. However, its involvement in cancer biology is unknown.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: LncRNA CTBP1-AS2 sponges miR-216a to upregulate PTEN and suppress endometrial cancer cell invasion and migration

2020

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“…From our perspective, most of the reported lncRNAs were abnormally upregulated in PTC samples and cells and have negative impact on outcome of PTC patients. For the cellular and molecular mechanisms, these lncRNAs may closely associated with some cell functions such as proliferation, migration, apoptosis, and invasion by regulating numerous signaling pathways . In this study, we focused on a new lncRNA called LINC00311, which was previously reported to be highly expressed in osteoclasts and elevated the expression Notch2 and TRAP mRNA .…”

Section: Discussionmentioning

confidence: 99%

Retracted: LINC00311 promotes cancer stem‐like properties by targeting miR‐330‐5p/TLR4 pathway in human papillary thyroid cancer

et al. 2020

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Growing evidence has suggested that long noncoding RNAs (lncRNAs) play an essential role in the progression of papillary thyroid cancer (PTC). LncRNA LINC00311 was found to be able to regulate many cellular process in several diseases. However, the function and regulatory mechanism of LINC00311 remains unclear in PTC. In the present study, the results showed that the expression of LINC00311 was upregulated in PTC tissues and cells. Furthermore, knockdown of LINC00311 dramatically suppressed spheroid formation, proliferation, migration, and invasion in PTC cells in vitro. Mechanistic investigations revealed that LINC00311 was negatively correlated with the expression of miR‐330‐5p, meanwhile, TLR4 was a direct target of miR‐330‐5p. In addition, rescue assays further determined that LINC00311 contributed to the progression of PTC through regulating TLR4 expression. Taken together, these findings indicated that LINC00311 could promote cancer stem‐like properties by targeting miR‐330‐5p/TLR4 pathway in PTC.

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“…In the cytoplasm, CTBP1-AS2 interacts with the RNA-binding protein fused in sarcoma (FUS) forming a ribonucleoparticle that includes also TLR4 mRNA. Both CTBP1-AS2 and FUS participate in the anomalous stabilization of TLR4 mRNA, which encodes for a well-known driver of the inflammation process at the base of cardiac hypertrophy (Luo et al, 2019).…”

Section: Cytoplasmic-enriched Lncrnasmentioning

confidence: 99%

Non-coding RNAs Shaping Muscle

Martone

Mariani

Desideri

et al. 2020

Front. Cell Dev. Biol.

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In 1957, Francis Crick speculated that RNA, beyond its protein-coding capacity, could have its own function. Decade after decade, this theory was dramatically boosted by the discovery of new classes of non-coding RNAs (ncRNAs), including long ncRNAs (lncRNAs) and circular RNAs (circRNAs), which play a fundamental role in the fine spatio-temporal control of multiple layers of gene expression. Recently, many of these molecules have been identified in a plethora of different tissues, and they have emerged to be more cell-type specific than protein-coding genes. These findings shed light on how ncRNAs are involved in the precise tuning of gene regulatory mechanisms governing tissues homeostasis. In this review, we discuss the recent findings on the mechanisms used by lncRNAs and circRNAs to sustain skeletal and cardiac muscle formation, paying particular attention to the technological developments that, over the last few years, have aided their genome-wide identification and study. Together with lncRNAs and circRNAs, the emerging contribution of Piwi-interacting RNAs and transfer RNA-derived fragments to myogenesis will be also discussed, with a glimpse on the impact of their dysregulation in muscle disorders, such as myopathies, muscle atrophy, and rhabdomyosarcoma degeneration.

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Sp1-induced LncRNA CTBP1-AS2 is a novel regulator in cardiomyocyte hypertrophy by interacting with FUS to stabilize TLR4

Cited by 36 publications

References 30 publications

RETRACTED ARTICLE: LncRNA CTBP1-AS2 sponges miR-216a to upregulate PTEN and suppress endometrial cancer cell invasion and migration

RETRACTED ARTICLE: LncRNA CTBP1-AS2 sponges miR-216a to upregulate PTEN and suppress endometrial cancer cell invasion and migration

Retracted: LINC00311 promotes cancer stem‐like properties by targeting miR‐330‐5p/TLR4 pathway in human papillary thyroid cancer

Non-coding RNAs Shaping Muscle

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