Sparing of the scalp in severe Demodex folliculitis after stem cell transplantation

Chen, Cynthia; Timerman, Dmitriy; Finnin, Christine Y.; Gallitano, Stephanie M.

doi:10.1016/j.jdcr.2018.09.013

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…The differential diagnosis led to taking facial scrapings of both patients what revealed demodicosis. Both patients' eruptions resolved after treatment with ivermectin and permethrin [13]. The authors stated that to that point (2018) there were only 5 reported cases of demodicosis after SCT that were mistaken with aGvHD [14][15][16][17].…”

Section: Demodicosis In Patients After Organ Transplantationmentioning

confidence: 99%

“…Chen et al . in another case report described 2 patients [ 13 ]. After about a month of immunosuppression therapy after SCT, erythematous papules with follicular prominence were reported.…”

Section: Demodicosis In Patients After Organ Transplantationmentioning

confidence: 99%

“…What can be interesting about those cases, is the sharp border between the scalp and forehead. The “cut off” sign in demodicosis can be an important diagnostic tool and may help distinguish it from cutaneous aGvHD [ 12 , 13 ].…”

Section: Demodicosis In Patients After Organ Transplantationmentioning

confidence: 99%

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Demodicosis among immunocompromised patients: a review

Marquardt-Feszler¹,

Cekała²,

Dębska‐Ślizień³

et al. 2022

pdia

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Introduction: Demodex mites (DM) are the most common ectoparasites of humans. Demodex folliculorum and Demodex brevis are the two species we are hosts for. Through the years there have been more data proving DM to be a pathogenic parasite. To this date it has not clear which groups of patients are clearly prone to develop demodicosis. Aim: To present a literature review in order to analyse and establish whether immunosuppressed patients are prone to develop demodicosis. Material and methods: Data were collected mostly from the PubMed database and through citation searching of the articles. Results: A total amount of 23 case reports and 13 original works were included. Out of them, 4 original works deny the correlation between demodicosis and immunosuppression whereas 9 original works suggest that correlation. Conclusions: Demodicosis seems to be correlated with immunosuppression, but it requires more study in the future.

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Section: Demodicosis In Patients After Organ Transplantationmentioning

confidence: 99%

“…Chen et al . in another case report described 2 patients [ 13 ]. After about a month of immunosuppression therapy after SCT, erythematous papules with follicular prominence were reported.…”

Section: Demodicosis In Patients After Organ Transplantationmentioning

confidence: 99%

See 1 more Smart Citation

Demodicosis among immunocompromised patients: a review

Marquardt-Feszler¹,

Cekała²,

Dębska‐Ślizień³

et al. 2022

pdia

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“…Under certain conditions, for instance, immunodeficiency or immunosuppression, the over-proliferation of Demodex mites could menace skin health and needs to be managed properly. Demodicosis with serious symptoms could be observed in patients infected with human immunodeficiency virus and patients receiving immunosuppressive regimens after transplantation [2, 3]. Moreover, as more and more immunosuppressing biologics have been developed, the strategy to encounter a resulting Demodex infestation or Demodex -related disease should attract more attention.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Different Anti-Demodex Strategies: A Systematic Review and Meta-Analysis

Wei¹,

Reisinger²,

French³

et al. 2022

Dermatology

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Background: Demodex mites are related to some inflammatory diseases such as rosacea and blepharitis and could be harmful in patients with immunodeficiency or immunosuppression, especially notable in patients using biologic like dupilumab. In order to have an objective observation of different anti-Demodex strategies, we conducted this study, based on interventional clinical evidence with quantified Demodex mite data. Methods: We used the PubMed, Embase, ClinicalTrials.gov, Medline, and International Clinical Trials Registry Platform (ICTRP) as databases. To assess the risk of bias, the RoB2 and ROBINS-I tools were used. The certainty of evidence was assessed following the GRADE guideline. Furthermore, the effect sizes (ESs) of different strategies were compared in different time periods (0–1, 1–2, 2–3, >3 months), as well as Demodex decrease rates. Results: 1,618 studies were identified in the databases, with 21 of which included in the final quantitative synthesis. Interventions in these studies included ivermectin, tea tree oil (TTO), permethrin, crotamiton, metronidazole, light therapies, combined therapies, and other therapies. During 0–1 month, the ES varied from 0.07 (cleanser) to 1.95 (systemic ivermectin-metronidazole). During 1–2 months, the ES varied from 0.88 (topical permethrin) to 4.40 (topical ivermectin). During 2–3 months, the ES varied from 0.79 (topical permethrin) to 8.37 (topical ivermectin). During the time of 3 months, the ES varied from 0.59 (topical permethrin) to 2.25 (intense pulsed light [IPL]). In terms of Demodex decrease rates, topical ivermectin, TTO, permethrin, IPL, and baby shampoo had achieved a nearly 100% decrease. The reported adverse events were mostly mild, without severe adverse events reported in any of the studies. Conclusions: We found ivermectin (topical and systemic), ivermectin-metronidazole (topical), and TTO (topical) are promising anti-Demodex interventions. In addition to traditional pharmacotherapy, light therapies, especially IPL and skin cleansing, could also be considered as effective methods to control Demodex mite infestation.

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“…Demodex folliculitis is a condition caused by inflammation of the pilosebaceous unit due to the Demodex folliculorum mite. 1 The mite is a normal inhabitant of the human hair follicle and though they have been found in all areas of human skin, they predominate on the face. The face, with a high density of active sebaceous glands is a desirable home for demodex mites who feed on exfoliated epidermal cells and sebaceous gland secretions.…”

Section: Introductionmentioning

confidence: 99%