The Spanish flu appeared at the end of the First World War and spread around
the world in three waves: spring-summer in 1918, which was mild; autumn
fatal wave, in the same year; and winter wave in 1919, which also had great
consequences. From the United States of America, as the cradle of its
origin, the Spanish flu spread to all the inhabited continents, and it did
not bypass Serbia either. Research on the Spanish flu, as the deadliest and
most widespread pandemic in the human history, was mostly based on
statistical researches. The development of the geographic information
systems and spatial analyses has enabled the implementation of the
information of location in existing researches, allowing the identification
of the spatial patterns of infectious diseases. The subject of this paper is
the spatial patterns of the share of deaths from the Spanish flu in the
total population in Valjevo Srez (in Western Serbia), at the settlement
level, and their determination by the geographical characteristics of the
studied area-the average altitude and the distance of the settlement from
the center of the Srez. This paper adopted hot spot analysis, based on Gi* statistic, and the results indicated pronounced spatial disparities (spatial
grouping of values), for all the studied parameters. The conclusions derived
from the studying of historical spatial patterns of infectious diseases and
mortality can be applied as a platform for defining measures in the case of
an epidemic outbreak with similar characteristics.