Spatial- and Task-Dependent Neuronal Responses during Real and Virtual Translocation in the Monkey Hippocampal Formation

Matsumura, Nobuhisa; Nishijo, Hisao; Tamura, Ryoi; Eifuku, Satoshi; Endo, Shunro; Ono, Taketoshi

doi:10.1523/jneurosci.19-06-02381.1999

Cited by 128 publications

(106 citation statements)

References 56 publications

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“…The place cell of the rodent HF is characterized by location-specific firing (O'Keefe and Conway, 1978;Eichenbaum et al, 1987;McHugh et al, 1996;Skaggs and McNaughton, 1998), and comparable HF neuron responses were also reported in monkeys (Ono et al, , 1993Nishijo et al, 1997;Matsumura et al, 1999). Place-cell activity is controlled by a salient cue or multiple spatial cues (e.g., O'Keefe and Conway, 1978;O'Keefe and Burgess, 1996), and remains stable over a long period Thompson and Best, 1990).…”

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confidence: 54%

Contribution of hippocampal place cell activity to learning and formation of goal-directed navigation in rats

et al. 2003

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Abstract-Although extensive behavioral studies have demonstrated that hippocampal lesions impair navigation toward specific places, the role of hippocampal neuronal activity in the development of efficient navigation during place learning remains unknown. The aim of the present study was to investigate how hippocampal neuronal activity changes as rats learn to navigate efficiently to acquire rewards in an open field. Rats were pre-trained in a random reward task where intracranial self-stimulation rewards were provided at random locations. Then, the rats were trained in a novel place task where they were rewarded at two specific locations as they repeatedly shuttled between them. Hippocampal neuronal activity was recorded during the course of learning of the place task. The rats learned reward sites within several sessions, and gradually developed efficient navigation strategies throughout the learning sessions. Some hippocampal neurons gradually changed spatial firing as the learning proceeded, and discharged robustly near the reward sites when efficient navigation was established. Over the learning sessions, the neuronal activity was highly correlated to formation of efficient shuttling trajectories between the reward sites. At the end of the experiment, spatial firing patterns of the hippocampal neurons were re-examined in the random reward task. The specific spatial firing patterns of the neurons were preserved if the rats navigated, as if they expected to find rewards at the previously valid locations. However, those specific spatial firing patterns were not observed in rats pursuing random trajectories.These results suggest that hippocampal neurons have a crucial role in formation of an efficient navigation.

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confidence: 54%

Contribution of hippocampal place cell activity to learning and formation of goal-directed navigation in rats

et al. 2003

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“…Comparable allocentric representations of physical location (Matsumura et al, 1999) and location of gaze (Rolls, Robertson, & Georges-Francois, 1997) have been reported in non-human primates. The recent discovery of place cells in the human hippocampus (Ekstrom et al, 2003) suggests that some of their properties (discussed below) may be applicable to understanding human spatial behavior.…”

Section: Forms Of Neural Representationmentioning

confidence: 90%

Geometric determinants of human spatial memory

2004

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Geometric alterations to the boundaries of a virtual environment were used to investigate the representations underlying human spatial memory. Subjects encountered a cue object in a simple rectangular enclosure, with distant landmarks for orientation. After a brief delay, during which they were removed from the arena, subjects were returned to it at a new location and orientation and asked to mark the place where the cue had been. On some trials the geometry (size, aspect ratio) of the arena was varied between presentation and testing. Responses tended to lie somewhere between a location that maintained fixed distances from nearby walls and a location that maintained fixed ratios of the distances between opposing walls. The former were more common after expansions and for cued locations nearer to the edge while the latter were more common after contractions and for locations nearer to the center. The spatial distributions of responses predicted by various simple geometric models were compared to the data. The best fitting model was one derived from the response properties of 'place cells' in the rat hippocampus, which matches the 'proximities' 1=ðd þ cÞ of the cue to the four walls of the arena, where d is the distance to a wall and c is a global constant. Subjects also tended to adopt the same orientation at presentation and testing, although this was not due to using a view matching strategy, which could be ruled out in 50% of responses. Disoriented responses were most often seen where the cued location was near the center of the arena or where the long axis of a rectangular arena was changed between presentation and testing, suggesting that the geometry of the arena acts as a weak cue to orientation. Overall, the results suggest a process of visual landmark matching to determine orientation, combined with an abstract representation of the proximity of the cued location to the walls of the arena consistent with the neural representation of location in the hippocampus. q

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“…primates when navigating in natural environments, although electrophysiological studies have identified neurons in primate hippocampus corresponding to egocentric and to geocentric representations of space (e.g., Feigenbaum & Rolls, 1991;Matsumura et al, 1999).…”

Section: Brief Reportsmentioning

confidence: 99%