Spatial aspects of blood coagulation: Two decades of research on the self-sustained traveling wave of thrombin

Guria, Konstantin G; Guria, Georgy Th.

doi:10.1016/j.thromres.2014.12.014

Cited by 18 publications

(10 citation statements)

References 87 publications

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“…The resulting reaction-diffusion system describe clot growth and emits travelling wave solutions. The concept of clot growth as a reaction-diffusion wave was introduced in the 1990s [85,81,66] starting an intensive investigation of wave dynamics and properties [82,86,87,88,89]. The main questions here are the determination of the conditions of wave initiation, the speed of its propagation and the mechanisms of its arrest.…”

Section: Coagulation In Quiescent Plasma With Space Distributionmentioning

confidence: 99%

Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones

Belyaev

Dunster

Gibbins

et al. 2018

Physics of Life Reviews

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Hemostasis is a complex physiological mechanism that functions to maintain vascular integrity under any conditions. Its primary components are blood platelets and a coagulation network that interact to form the hemostatic plug, a combination of cell aggregate and gelatinous fibrin clot that stops bleeding upon vascular injury. Disorders of hemostasis result in bleeding or thrombosis, and are the major immediate cause of mortality and morbidity in the world. Regulation of hemostasis and thrombosis is immensely complex, as it depends on blood cell adhesion and mechanics, hydrodynamics and mass transport of various species, huge signal transduction networks in platelets, as well as spatiotemporal regulation of the blood coagulation network. Mathematical and computational modeling has been increasingly used to gain insight into this complexity over the last 30 years, but the limitations of the existing models remain profound. Here we review state-of-the-art-methods for computational modeling of thrombosis with the specific focus on the analysis of unresolved challenges. They include: a) fundamental issues related to physics of platelet aggregates and fibrin gels; b) computational challenges and limitations for solution of the models that combine cell adhesion, hydrodynamics and chemistry; c) biological mysteries and unknown parameters of processes; d) biophysical complexities of the spatiotemporal networks' regulation. Both relatively classical approaches and innovative computational techniques for their solution are considered; the subjects discussed with relation to thrombosis modeling include coarse-graining, continuum versus particle-based modeling, multiscale models, hybrid models, parameter estimation and others. Fundamental understanding gained from theoretical models are highlighted and a description of future prospects in the field and the nearest possible aims are given.

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Section: Coagulation In Quiescent Plasma With Space Distributionmentioning

confidence: 99%

Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones

Belyaev

Dunster

Gibbins

et al. 2018

Physics of Life Reviews

View full text Add to dashboard Cite

show abstract

“…The subject of flow in general was discussed in several review papers beginning from 1990 [25][26][27][28][29]. Some of the spatial aspects of coagulation were recently reviewed in [30]; the authors believe that all processes of spatial propagation of blood coagulation are explained by a travelling-wave-like motion of thrombin impulse from the site of damage, while, as discussed below, this is just one possibility that is currently supported by limited in vitro evidence.…”

Section: Introduction: Is There Anything In Blood Coagulation Beyondmentioning

confidence: 99%

Hemostasis and thrombosis beyond biochemistry: roles of geometry, flow and diffusion

Panteleev

Dashkevich

Ataullakhanov

2015

Thrombosis Research

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“…Gamma-glutamyl carboxylase (GGCX) catalyzes the posttranslational modification of vitamin K-dependent proteins which are involved in coagulation [ 78 ]. F2 is also known as thrombin (IIa) acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin and activation of thrombin is crucial in physiological and pathological coagulation [ 79 ]. SERPIND1, known as heparin cofactor II, is a coagulation factor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin.…”

Section: Resultsmentioning

confidence: 99%

The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis

Zheng

Zhang

Qiao

2015

Evidence-Based Complementary and Alternative Medicine

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Qishen Yiqi formula (QSYQ) has the effect of tonifying Qi and promoting blood circulation, which is widely used to treat the cardiovascular diseases with Qi deficiency and blood stasis syndrome. However, the mechanism of QSYQ to tonify Qi and promote blood circulation is rarely reported at molecular or systems level. This study aimed to elucidate the mechanism of QSYQ based on the protein interaction network (PIN) analysis. The targets' information of the active components was obtained from ChEMBL and STITCH databases and was further used to search against protein-protein interactions by String database. Next, the PINs of QSYQ were constructed by Cytoscape and were analyzed by gene ontology enrichment analysis based on Markov Cluster algorithm. Finally, based on the topological parameters, the properties of scale-free, small world, and modularity of the QSYQ's PINs were analyzed. And based on function modules, the mechanism of QSYQ was elucidated. The results indicated that Qi-tonifying efficacy of QSYQ may be partly attributed to the regulation of amino acid metabolism, carbohydrate metabolism, lipid metabolism, and cAMP metabolism, while QSYQ improves the blood stasis through the regulation of blood coagulation and cardiac muscle contraction. Meanwhile, the “synergy” of formula compatibility was also illuminated.

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Spatial aspects of blood coagulation: Two decades of research on the self-sustained traveling wave of thrombin

Cited by 18 publications

References 87 publications

Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones

Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones

Hemostasis and thrombosis beyond biochemistry: roles of geometry, flow and diffusion

The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis

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