Purpose of research: to study dynamics of infectious and parasitic diseases (for 2008-2013 years) among the children population in Dnipro region and to define influence of water factor on the disease and prevalence given class of illnesses. Materials and methods. Retrospective study of infectious and parasitogenic diseases (І class by ICD-10) among children population from rural districts of Dnipropetrovsk region for 2008-2013 years was carried out. It was spent correlation analysis between some indicators of potable water quality of diseases of the given class in all districts. In the majority of rural districts, was shown increasing І class of diseases from (1.4 to 1.63) times in dynamics for 2008-2013 years. In some districts was reveled an average correlation link between content in water of the dry residue, chlorides, sulphates, calcium, magnesium, except rigidity and iron and prevalence І class of diseases (r=0.50, p<0.001). Prevalence of the given class of diseases was correlated with рН, nitrates, oxidability in the three rural districts of Dnipropetrovsk region (r=0.74-0.89, p<0.001). We did not found health effects of higher levels of iron, manganese and arsenic in water from shallow tube wells on the children population morbidity, such as: arsenicosis, skin diseases, skin cancers, internal cancers (bladder, kidney, and lung), diabetes, raised blood pressure, and reproductive disorders, children's cognitive, behavioral, and neuropsychological health disorders.