Spatial learning affects immature granule cell survival in adult rat dentate gyrus

Ambrogini, Patrizia; Cuppini, Riccardo; Cuppini, C; Ciaroni, Sandra; Cecchini, Tiziana; Ferri, Paola; Sartini, Stefania; Grande, Paolo Del

doi:10.1016/s0304-3940(00)01074-0

Cited by 182 publications

(148 citation statements)

References 17 publications

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“…Several lines of evidence support this hypothesis: (i) strong correlation between the rate of neurogenesis and spatial learning in the water maze among mice inbred strains 61 and in old rats from an outbreed strain. 62 (ii) manipulations in which inhibiting hippocampal neurogenesis resulted in hippocampus-dependent learning deficits; 32,45,63 and (iii) observations that learning itself can enhance the survival rate of new hippocampal neurons, [64][65][66] and induce apoptosis of more immature cells and proliferation of neural precursors. 67 However, other studies found the opposite (that is negative) correlation between the rate of hippocampal cell proliferation and spatial learning 68 or failed to find deficits in hippocampus-dependent learning after ablation of hippocampal neurogenesis.…”

Section: Discussionmentioning

confidence: 99%

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors

et al. 2010

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Intensive research is devoted to unravel the neurobiological mechanisms mediating adult hippocampal neurogenesis, its regulation by antidepressants, and its behavioral consequences. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is expressed in the CNS, where its function is unknown. Here, we show, for the first time, the relevance of MIF expression for adult hippocampal neurogenesis. We identify MIF expression in neurogenic cells (in stem cells, cells undergoing proliferation, and in newly proliferated cells undergoing maturation) in the subgranular zone of the rodent dentate gyrus. A causal function for MIF in cell proliferation was shown using genetic (MIF gene deletion) and pharmacological (treatment with the MIF antagonist Iso-1) approaches. Behaviorally, genetic deletion of MIF resulted in increased anxiety-and depression-like behaviors, as well as of impaired hippocampus-dependent memory. Together, our studies provide evidence supporting a pivotal function for MIF in both basal and antidepressant-stimulated adult hippocampal cell proliferation. Moreover, loss of MIF results in a behavioral phenotype that, to a large extent, corresponds with alterations predicted to arise from reduced hippocampal neurogenesis. These findings underscore MIF as a potentially relevant molecular target for the development of treatments linked to deficits in neurogenesis, as well as to problems related to anxiety, depression, and cognition.

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Section: Discussionmentioning

confidence: 99%

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors

et al. 2010

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“…However, the direction of the effect is not always the same. For example, it has been shown that training with trace eyeblink conditioning, spatial learning in the Morris water maze and conditioned food preference increase the number of newborn cells in the DG of adult rats (Gould et al, 1999c;Ambrogini et al, 2000;Lemaire et al, 2000;Dobrossy et al, 2003;Leuner et al, 2004c;Hairston et al, 2005;Olariu et al, 2005). These effects appear to be specific to learning that requires the hippocampus.…”

Section: Evidence In Favormentioning

confidence: 99%

“…Trace eyeblink conditioning and water maze training enhance the survival of new cells born one week prior to training, when they are during early stages of differentiation and most susceptible to cell death (Gould et al, 1999c;Ambrogini et al, 2000). In contrast, learning appears to decrease the survival of older and perhaps more mature newborn neurons (Ambrogini et al, 2004a).…”

Section: Evidence Againstmentioning

confidence: 99%

Is there a link between adult neurogenesis and learning?

2006

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During the past several years, evidence has accumulated suggesting a relationship between newly born cells in the hippocampus and various types of learning and memory. However, most of the evidence is correlational and some of it does not agree. This review discusses both sides of this issue, considering the effects of learning on the production of new neurons in the dentate gyrus and the question of whether newly born cells participate in learning and memory.

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“…A second and emerging hypothesis regarding the mechanisms by which EE mediates cognitive recovery is that neural progenitors may replace neurons and restore neural networks damaged by brain injury [1,45,60]. In support of this hypothesis, EE improves spatial learning in intact animals [13,54,81] and increases neurogenesis in the dentate gyrus of the hippocampus [54,81].…”

Section: Introductionmentioning

confidence: 95%

“…Endogenous neural stem cells may also be capable of replacing lost neurons [1,15,29,48,49,58,66]. Although brain injury by itself produces a rapid and profound increase in neural progenitors, the increase is transient and the majority of cells do not survive [10,12,41,42,46,70,74].…”

Section: Introductionmentioning

confidence: 99%

Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury

Gaulke

Horner

Fink

et al. 2005

Molecular Brain Research

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Neurons in the hilus of the dentate gyrus are lost following a lateral fluid percussion injury. Environmental enrichment is known to increase neurogenesis in the dentate in intact rats, suggesting that it might also do so following fluid percussion injury, and potentially provide replacements for lost neurons. We report that 1 hour of daily environmental enrichment for 3 weeks increased the number of progenitor cells in the dentate following fluid percussion injury, but only on the ipsilesional side. In the dentate granule cell layer, but not the hilus, most progenitors had a neuronal phenotype. The rate of on going cell proliferation was similar across groups. Collectively these results suggest that the beneficial effects of environmental enrichment on behavioral recovery following FP injury are not attributable to neuronal replacement in the hilus, but may be related to increased neurogenesis in the granule cell layer.

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Spatial learning affects immature granule cell survival in adult rat dentate gyrus

Cited by 182 publications

References 17 publications

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors

Is there a link between adult neurogenesis and learning?

Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury

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