Spatial organization of the reciprocal connections between the cat dorsal and anteroventral cochlear nuclei

Em, Ostapoff; Morest, D. Kent; Parham, Kourosh

doi:10.1016/s0378-5955(98)00224-x

Cited by 24 publications

(24 citation statements)

References 53 publications

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“…Within the band of label in the VCN, stellate cells are relatively small and are oriented in the plane of the tonotopic lamina (Doucet and Ryugo 1997;Ostapoff et al 1999), while stellate cells, outside the band of label (sometimes very far removed from the labeled band), are large and have been described as ''giant'' (Ostapoff et al 1999) The functional significance of onset cell innervation of the DCN Important functions that have been attributed to the DCN include extraction and processing of information pertaining to sound source location (Davis and Young 2000) and speech formants (Rhode and Greenberg 1994a, b). Principal output neurones of the DCN, termed type IV or fusiform neurones, have been found to be extremely sensitive to the frequency position of sharp spectral notches (for review see Young and Davis 2002).…”

Section: Innervation Of the Ipsilateral Dcnmentioning

confidence: 99%

Onset Neurones in the Anteroventral Cochlear Nucleus Project to the Dorsal Cochlear Nucleus

Arnott

Wallace

Shackleton

et al. 2004

JARO

113

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Considerable circumstantial evidence suggests that cells in the ventral cochlear nucleus, that respond predominantly to the onset of pure tone bursts, have a stellate morphology and project, among other places, to the dorsal cochlear nucleus. The characteristics of such cells make them leading candidates for providing the so-called ''wideband inhibitory input'' which is an essential part of the processing machinery of the dorsal cochlear nucleus. Here we use juxtacellular labeling with biocytin to demonstrate directly that large stellate cells, with onset responses, terminate profusely in the dorsal cochlear nucleus. They also provide widespread local innervation of the anteroventral cochlear nucleus and a small innervation of the posteroventral cochlear nucleus. In addition, some onset cells project to the contralateral dorsal cochlear nucleus.

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Section: Innervation Of the Ipsilateral Dcnmentioning

confidence: 99%

Onset Neurones in the Anteroventral Cochlear Nucleus Project to the Dorsal Cochlear Nucleus

Arnott

Wallace

Shackleton

et al. 2004

JARO

113

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“…The methods were described in detail by Ostapoff et al (1999). In brief, a craniotomy was carried out, and enough cerebellar tissue was removed to expose the underlying DCN.…”

Section: Surgery and Dextran-biotin Injectionmentioning

confidence: 99%

“…Such a circuit would provide the basis for a temporally delayed modulation of signals, following the main afferent pathway from the cochlear nerve to the neurons of the AVCN, which project upstream to support parallel processing. For example, pre-pulse inhibition, echo suppression, masking and precedence effects have been suggested as possible functional properties of the tuberculo-ventral pathway (Wickesberg and Oertel, 1990; and others, cited by Ostapoff et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…1. Connections between different parts of the ventral cochlear nucleus (VCN) and the dorsal cochlear nucleus (DCN) (modified from Ostapoff et al, 1999). LEFT: Ventro-tubercular projections seen by retrograde labeling of AVCN cells following injection of biotinylated dextran amine into the 9 kHz region of DCN.…”

Section: Introductionmentioning

confidence: 99%

“…In a previous study, Ostapoff et al (1999) found that the reciprocal connections between the DCN and the AVCN could be analyzed with reference to a main band of the frequency spectrum and the side bands flanking it. However, the tract tracing method (biotinylated dextran amine) permitted both anterograde and retrograde transport of the label in the cochlear nerve branches as well as in the interconnections of the DCN and AVCN.…”

Section: Introductionmentioning

confidence: 99%

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Organization of inhibitory feed-forward synapses from the dorsal to the ventral cochlear nucleus in the cat: a quantitative analysis of endings by vesicle morphology

et al. 2004

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Structural and functional classes of multipolar cells in the ventral cochlear nucleus

Doucet

Ryugo

2006

Anat. Rec.

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Multipolar cells in the ventral cochlear nucleus (VCN) are a structurally and functionally diverse group of projection neurons. Understanding their role in the ascending pathway involves partitioning multipolar cells into distinct populations and determining where in the brain each sends its coded messages. In this study, we used retrograde labeling techniques in rats to identify multipolar neurons that project their axons to the ipsilateral dorsal cochlear nucleus (DCN), the contralateral CN, or both structures. Three rats received injections of biotinylated dextran amine in the ipsilateral DCN and diamidino yellow in the contralateral CN. Several radiate multipolar neurons (defined by their axonal projections to the ipsilateral DCN and their dendrites that traverse VCN isofrequency sheets) were double-labeled but over 70% were not. This result suggests two distinct populations: (1) radiate-commissural (RC) multipolar cells that project to the ipsilateral DCN and the contralateral CN, and (2) radiate multipolar cells that project exclusively (in this context) to the ipsilateral DCN. In a different group of animals, we retrogradely labeled multipolar neurons that project their axons to the contralateral CN and measured the size of their cell bodies. The mean size of this population (266 Ϯ 156 m 2 ) was significantly smaller than those of RC-multipolar cells (418 Ϯ 140 m 2 ). We conclude that the CN commissural pathway is composed of at least two components: (1) RC multipolar cells and (2) commissural multipolar cells that are small-and medium-sized neurons that project exclusively (in this context) to the contralateral CN. These results identify separate structural groups of multipolar cells that may correspond to physiological unit types described in the literature. They also provide protocols for isolating and studying different populations of multipolar cells to determine the neural mechanisms that govern their responses to sound. Anat Rec Part 288A:331-344, 2006. Key words: hearing; ascending pathways; classifying neurons; naming neuronsInformation about sound is conveyed to the brain by patterns of action potentials in the auditory nerve. These patterns are analyzed first by neurons in the cochlear nucleus (CN) that are the source of all ascending pathways in the central auditory system. An important step toward understanding the neural circuits that underlie hearing is to define how CN neurons divide, select, and encode the enormous amount of acoustic information that they receive.Dendritic morphology can be used to partition ventral cochlear nucleus (VCN) projection neurons into three groups: bushy, multipolar, and octopus. Octopus cells are located in the caudal pole of the VCN and they are distinguished by several long dendrites that extend from one side of the cell body. Bushy cells usually have one or two primary dendrites. Shortly after arising from the soma, each primary dendrite ends in a spray of thinner and

show abstract

Spatial organization of the reciprocal connections between the cat dorsal and anteroventral cochlear nuclei

Cited by 24 publications

References 53 publications

Onset Neurones in the Anteroventral Cochlear Nucleus Project to the Dorsal Cochlear Nucleus

Onset Neurones in the Anteroventral Cochlear Nucleus Project to the Dorsal Cochlear Nucleus

Organization of inhibitory feed-forward synapses from the dorsal to the ventral cochlear nucleus in the cat: a quantitative analysis of endings by vesicle morphology

Structural and functional classes of multipolar cells in the ventral cochlear nucleus

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