Spatial orientation strategies in Morris-type virtual water task for humans

Kállai, János; Makány, Tamás; Karádi, Kázmér; Jacobs, W. Jake

doi:10.1016/j.bbr.2004.10.015

Cited by 70 publications

(54 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A detailed statistical analysis demonstrated that the latency of the escape platform finding depends on the rate of the thigmotaxis in the middle part of the trials but does not depend on the thigmotaxis activity in the first trial. Based on previous findings in this field (Fanselow 2000;Kallai et al 2005), the first trial is considered as a habituation phase of a novel situation. During the habituation process, while calibrating the undefined space, participant's attach to the outer borders of the enclosed place has been observed.…”

Section: Discussionmentioning

confidence: 99%

“…A computer-generated virtual arena maze (CGArena; Jacobs et al 1997) and a real arena maze (RAM; Kallai et al 2005) tasks were utilized to assess subjects' expertise and thigmotaxis activity.…”

Section: Apparatusmentioning

confidence: 99%

“…The leading factor of exploration movement variation in the MWM is the thigmotaxis. During goaldirected exploration, the thigmotaxis inhibits the acquisition of the spatial relationships among the contextual cues, on the other hand serves as the definition of the border for an enclosed place and form of egocentric references to the proposed actions (Kallai et al 2005). This contradictory function of the anxiety-dependent thigmotaxis strategy reveals a basic neural organization conflict between the allocentric and egocentric reference frame-utilized spatial learning dynamics.…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Anxiety-dependent spatial navigation strategies in virtual and real spaces

2009

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Apparatusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Anxiety-dependent spatial navigation strategies in virtual and real spaces

2009

View full text Add to dashboard Cite

“…The pattern of exploratory behaviors reported above, which includes locomotor activity patterns, thigmotaxis, and habituation learning when facing a novel environment are not only well conserved between species, including rodents (Treit and Fundytus, 1988;Simon et al, 1994;Choleris et al, 2001;Sousa et al, 2006), fish (Lockwood et al, 2004;SharMa et al, 2009;Champagne et al, 2010), and humans (Kallai et al, 2005(Kallai et al, , 2007Henry et al, 2010) but also emerge early in life and serve as a good predictor of adult patterns of behavior (Henry et al, 2010;Kavsek and Bornstein, 2010;Wong et al, 2010). The open field test has proven to be a good animalto-man translational system (Perry et al, 2009;Henry et al, 2010).…”

Section: The Open Field Testmentioning

confidence: 96%

Zebrafish embryos and larvae: A new generation of disease models and drug screens

Ali

Champagne

Spaink

et al. 2011

Birth Defects Research Part C: Embryo Today: Reviews

224

135

View full text Add to dashboard Cite

Technological innovation has helped the zebrafish embryo gain ground as a disease model and an assay system for drug screening. Here, we review the use of zebrafish embryos and early larvae in applied biomedical research, using selected cases. We look at the use of zebrafish embryos as disease models, taking fetal alcohol syndrome and tuberculosis as examples. We discuss advances in imaging, in culture techniques (including microfluidics), and in drug delivery (including new techniques for the robotic injection of compounds into the egg). The use of zebrafish embryos in early stages of drug safety-screening is discussed. So too are the new behavioral assays that are being adapted from rodent research for use in zebrafish embryos, and which may become relevant in validating the effects of neuroactive compounds such as anxiolytics and antidepressants. Readouts, such as morphological screening and cardiac function, are examined. There are several drawbacks in the zebrafish model. One is its very rapid development, which means that screening with zebrafish is analogous to "screening on a run-away train." Therefore, we argue that zebrafish embryos need to be precisely staged when used in acute assays, so as to ensure a consistent window of developmental exposure. We believe that zebrafish embryo screens can be used in the pre-regulatory phases of drug development, although more validation studies are needed to overcome industry scepticism. Finally, the zebrafish poses no challenge to the position of rodent models: it is complementary to them, especially in early stages of drug research.

show abstract

“…Some researchers created virtual versions of the water maze (Kallai et al, 2005), others used open space versions consisting of a huge circle with a concealed target, or a pool filled with small plastic balls instead of water for the study of spatial orientation in children (overman et al 1996).…”

mentioning

confidence: 99%

Developing Spatial Knowledge in the Absence of Vision: Allocentric and Egocentric Representations Generated by Blind People When Supported by Auditory Cues

Corazzini¹,

Tinti²,

Schmidt

et al. 2010

PSYCHOL BELG

View full text Add to dashboard Cite

The study of visuospatial representations and visuospatial memory can profit from the analysis of the performance of specific groups. in particular, the surprising skills and limitations of blind people may be an important source of information. For example, converging evidence indicates that, even though blind individuals are able to develop both egocentric and allocentric space representations, the latter tend to be much more restricted than those in blindfolded sighted individuals. however, no study has explored yet whether this conclusion also holds when people receive practice with the spatial environment and are supported by auditory stimuli. The present research examined these issues with the use of an experimental apparatus based on the morris Water maze (morris et al., 1982). in this setup, blind people and blindfolded controls were given the opportunity to develop knowledge of the environment with the support of simultaneous auditory cues. The results show that even in this favourable case blind people spontaneously maintain to rely on an egocentric spatial representation.

show abstract

Spatial orientation strategies in Morris-type virtual water task for humans

Cited by 70 publications

References 32 publications

Anxiety-dependent spatial navigation strategies in virtual and real spaces

Anxiety-dependent spatial navigation strategies in virtual and real spaces

Zebrafish embryos and larvae: A new generation of disease models and drug screens

Developing Spatial Knowledge in the Absence of Vision: Allocentric and Egocentric Representations Generated by Blind People When Supported by Auditory Cues

Contact Info

Product

Resources

About