Spatial resolution of the HRRT PET scanner using 3D-OSEM PSF reconstruction

Olesen, Ole Vendelin; Sibomana, M.; Keller, Sune H.; Andersen, Flemming; Jensen, Jørgen Arendt; Holm, Søren; Svarer, Claus; Højgaard, Liselotte

doi:10.1109/nssmic.2009.5401892

Cited by 39 publications

(28 citation statements)

References 3 publications

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“…PET data were acquired in list mode on a Siemens HRRT scanner operating in 3D acquisition mode with an approximate in-plane resolution of 2 mm (1.4 mm in the center of the field of view and 2.4 mm in cortex; Olesen et al, 2009). PET frames were reconstructed using a 3D-OSEM-PSF algorithm Sureau et al, 2008).…”

Section: Methodsmentioning

confidence: 99%

A High-ResolutionIn VivoAtlas of the Human Brain's Serotonin System

et al. 2016

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The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain functions and is critically involved in many neuropsychiatric disorders. Here, we present a high-resolution, multidimensional, in vivo atlas of four of the human brain's 5-HT receptors (5-HT 1A , 5-HT 1B , 5-HT 2A , and 5-HT 4 ) and the 5-HT transporter (5-HTT). The atlas is created from molecular and structural high-resolution neuroimaging data consisting of positron emission tomography (PET) and magnetic resonance imaging (MRI) scans acquired in a total of 210 healthy individuals. Comparison of the regional PET binding measures with postmortem human brain autoradiography outcomes showed a high correlation for the five 5-HT targets and this enabled us to transform the atlas to represent protein densities (in picomoles per milliliter). We also assessed the regional association between protein concentration and mRNA expression in the human brain by comparing the 5-HT density across the atlas with data from the Allen Human Brain atlas and identified receptor-and transporter-specific associations that show the regional relation between the two measures. Together, these data provide unparalleled insight into the serotonin system of the human brain.

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Section: Methodsmentioning

confidence: 99%

A High-ResolutionIn VivoAtlas of the Human Brain's Serotonin System

et al. 2016

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“…The study was approved by the Ethics Committee of Copenhagen, Denmark and was in accordance with the Helsinki II declaration. Scans were performed on an ECAT High Resolution Research Tomograph (HRRT, Siemens) dedicated brain PET scanner [1] with a resolution down to 1.4 mm [14]. The scans were reconstructed with the 3D-OSEM PSF algorithm (16 subsets and 10 iterations).…”

Section: A Pet Data Acquisitionmentioning

confidence: 99%

Automatic thresholding for frame-repositioning using external tracking in PET brain imaging

Olesen

Keller

Sibomana

et al. 2010

IEEE Nuclear Science Symposuim &Amp; Medical Imaging Conference

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 Abstract -Motion correction (MC) in positron emission tomography (PET) brain imaging become of higher importance with increasing scanner resolution. Several motion correction methods have been suggested and so far the Polaris Vicra tracking system has been the preferred one for motion registration.We present an automated algorithm for dividing PET acquisitions into subframes based on the registered head motion to correct for intra-frame motion with the frame repositioning MC method. The method is tested on real patient data (five 11 C-SB studies and five 11 C-PIB studies) and compared with an image based registration method (AIR). Quantitative evaluation was done using a correlation measure. The study shows that MC improves the correlation of the PET images and that AIR performed slightly better than the Polaris Vicra. We found significant intra-frame motion of 1-5 mm in 9 frames but the correlation was not significantly improved using intra-frame MC.

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“…Patient motion lowers image quality, especially for high resolution PET scanners. The High Resolution Research Tomograph (HRRT, Siemens) is a brain-dedicated scanner, with a resolution down to 1.4 mm when using a new 3-D ordered subset expectation maximization (OSEM) reconstruction algorithm with resolution modeling [1]. This method incorporates a spatially invariant point spread function (PSF) [2], [3].…”

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A Movable Phantom Design for Quantitative Evaluation of Motion Correction Studies on High Resolution PET Scanners

Olesen

Svarer

Sibomana

et al. 2010

IEEE Trans. Nucl. Sci.

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Head movements during brain imaging using high resolution positron emission tomography (PET) impair the image quality which, along with the improvement of the spatial resolution of PET scanners, in general, raises the importance of motion correction. Here, we present a new design for an automatic, movable, mechanical PET phantom to simulate patients' head movements while being scanned. This can be used for evaluating motion correction methods. A low-cost phantom controlled by a rotary stage motor was built and tested for axial rotations of 1 10 with the multiple acquisition frame method. The phantom is able to perform stepwise and continuous axial rotations with submillimeter accuracy, and the movements are repeatable. The scans were acquired on the high resolution research tomograph dedicated brain scanner. The scans were reconstructed with the new 3-D ordered subset expectation maximization algorithm with modeling of the point spread function (3DOSEM-PSF), and they were corrected for motions based on external tracking information using the Polaris Vicra real-time stereo motion-tracking system. The new automatic, movable phantom has a robust design and is a potential quality assessment tool for the development and evaluation of future motion correction methods.

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Spatial resolution of the HRRT PET scanner using 3D-OSEM PSF reconstruction

Cited by 39 publications

References 3 publications

A High-ResolutionIn VivoAtlas of the Human Brain's Serotonin System

A High-ResolutionIn VivoAtlas of the Human Brain's Serotonin System

Automatic thresholding for frame-repositioning using external tracking in PET brain imaging

A Movable Phantom Design for Quantitative Evaluation of Motion Correction Studies on High Resolution PET Scanners

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