The macrofauna associated with Sargassum species is relatively well known on the coast of São Paulo, in studies conducted mainly in continental shore areas. On the other hand, investigations on the molluscan fauna associated with Sargassum are still rare in Brazil and there are no studies comparing the composition and variation of molluscan communities associated with this brown alga in relation to continental and oceanic islands faces. Thus, in this study, we evaluated the composition, richness, diversity and geographic distribution of these communities, comparing areas facing the continent and open ocean areas on the Island of São Sebastião, São Paulo, to contribute with biodiversity knowledge. The biomass and size of Sargassum, as well epibiosis and species composition, varied between beaches and sampling periods, but showed no variation between island faces. Most molluscs occurred in the last sampling period, with higher temperatures, which may be a period of species recruitment. Furthermore, epibiosis proved to be very important for the establishment of associated molluscan species, and contributes to higher diversity. Overall, the collected species are commonly found in Sargassum beds, and were recorded in other studies. Most were small species or juveniles of large and sessile ones, suggesting that Sargassum beds play an important role in the early stages of development of molluscan species. These species may find better living conditions in these environments during their juvenile stages.