2020
DOI: 10.1016/j.neuropharm.2019.107807
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Spatiotemporal brain activation pattern following acute citalopram challenge is dose dependent and associated with neuroticism: A human phMRI study

Abstract: Intravenous citalopram acutely elicited brain activation in several regions involved in serotonergic neurotransmission. • Acute citalopram challenge produced a chemically-induced brain state similar to increased arousal. • Significant dose-dependent activation was demonstrated in the middle cingulate gyrus, a region with neuroticism-related functions. • The neuroticism personality trait was associated with the individual responses to citalopram challenge. • These results may further support the modulating effe… Show more

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Cited by 6 publications
(3 citation statements)
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“…Finally, our results indirectly add to evidence implicating baseline serotonergic functioning in antidepressant response (Serretti et al, 2007). Neuroticism has been consistently linked to serotonin functioning in drug challenges, including those involving acute citalopram administration (Edes et al, 2020; Wright et al, 2019) and in PET studies examining serotonin receptor binding (Allen & DeYoung, 2016). Changes in neuroticism also mediate the effects of some SSRIs (Quilty et al, 2008; Tang et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Finally, our results indirectly add to evidence implicating baseline serotonergic functioning in antidepressant response (Serretti et al, 2007). Neuroticism has been consistently linked to serotonin functioning in drug challenges, including those involving acute citalopram administration (Edes et al, 2020; Wright et al, 2019) and in PET studies examining serotonin receptor binding (Allen & DeYoung, 2016). Changes in neuroticism also mediate the effects of some SSRIs (Quilty et al, 2008; Tang et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Intravenous administration of the drug is favored to avoid pharmacokinetic issues [ 43 ]. Acute citalopram challenge induces an increased arousal-like state [ 45 ] and a neuroendocrine stress response by increasing prolactin, ACTH, and cortisol release by stimulating the hypothalamic–pituitary–adrenal (HPA) axis [ 46 , 47 ]. Therefore, it is used as a neuroendocrine challenge to examine acute stress response [ 43 , 46 , 47 ].…”
Section: Introductionmentioning
confidence: 99%
“…It has the same therapeutic effect as other SSRIs, and has fewer side effects than older-generation antidepressants. Escitalopram is also the least expensive antidepressant available to date (7). Escitalopram is used by some physicians to treat the social anxiety, obsessive-compulsive, panic, posttraumatic stress disorders (8); but the effect of escitalopram on the neurotic patients recovery is not fully clear and few studies have been done in this field (9)(10)(11) .…”
Section: Introductionmentioning
confidence: 99%