Spatiotemporal characterization of the field-induced insulator-to-metal transition

Valle, Javier del; Vargas, Nicolás M.; Rocco, Rodolfo; Salev, Pavel; Kalcheim, Yoav; Lapa, Pavel N.; Adda, Coline; Lee, Min‐Han; Wang, Paul Y.; Fratino, Lorenzo; Rozenberg, Marcelo; Schuller, Iván K.

doi:10.1126/science.abd9088

Cited by 75 publications

(94 citation statements)

References 49 publications

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“…However, unlike most mammalian mRNAs, the coronavirus genome has several ORFs between the 5’ end and the 3’ end, both of which contain cis-acting signals involved in RNA replication ( 11 , 12 ). The transcribed sgRNA contain a common 5’ leader sequence with 72-nt long, which is derived from the 5’ end of viral genome ( 33 , 62 , 66 ) ( Figure 1B ).…”

Section: Proteins Encoded By Coronavirus Genomementioning

confidence: 99%

Translational Control of COVID-19 and Its Therapeutic Implication

et al. 2022

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, which has broken out worldwide for more than two years. However, due to limited treatment, new cases of infection are still rising. Therefore, there is an urgent need to understand the basic molecular biology of SARS-CoV-2 to control this virus. SARS-CoV-2 replication and spread depend on the recruitment of host ribosomes to translate viral messenger RNA (mRNA). To ensure the translation of their own mRNAs, the SARS-CoV-2 has developed multiple strategies to globally inhibit the translation of host mRNAs and block the cellular innate immune response. This review provides a comprehensive picture of recent advancements in our understanding of the molecular basis and complexity of SARS-CoV-2 protein translation. Specifically, we summarize how this viral infection inhibits host mRNA translation to better utilize translation elements for translation of its own mRNA. Finally, we discuss the potential of translational components as targets for therapeutic interventions.

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Section: Proteins Encoded By Coronavirus Genomementioning

confidence: 99%

Translational Control of COVID-19 and Its Therapeutic Implication

et al. 2022

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“…Interestingly, recent work by Del Valle et al provides new experimental insight on the process of filamentary incubation. 43 Modifying the local defect concentration presents an appealing and effective new way of modifying the Mott metalinsulator transition. Examples include: controlling oxygen vacancies in vanadates, 44 doping rare-earth nickelates (e.g., SmNiO 3 ) with light ions such as hydrogen, 45 and controlling vacancies and doping in LaCoO 3 .…”

Section: A Metal-insulator Transitions In Quantum Materialsmentioning

confidence: 99%

Quantum materials for energy-efficient neuromorphic computing

Hoffmann,

Ramanathan,

Grollier

et al. 2022

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Neuromorphic computing approaches become increasingly important as we address future needs for efficiently processing massive amounts of data. The unique attributes of quantum materials can help address these needs by enabling new energy-efficient device concepts that implement neuromorphic ideas at the hardware level. In particular, strong correlations give rise to highly non-linear responses, such as conductive phase transitions that can be harnessed for short and long-term plasticity. Similarly, magnetization dynamics are strongly non-linear and can be utilized for data classification. This paper discusses select examples of these approaches, and provides a perspective for the current opportunities and challenges for assembling quantum-material-based devices for neuromorphic functionalities into larger emergent complex network systems.

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“…In particular, optical control of VO 2 ’s phase transition at room temperature has great potential for investigating the intrinsic physical mechanism and realizing optical modulation devices. Currently, optical pumping is used to induce the photoexcitation insulator-metal phase transition, which promises to allow vital insights into the nature of each state and may lead to metastable new phases under non-equilibrium conditions 29 – 32 . However, being an ultrafast excitation, such optical means cannot introduce stable phase transition; instead, a transient process on the picosecond scale is induced.…”

Section: Introductionmentioning

confidence: 99%

Photo-induced non-volatile VO2 phase transition for neuromorphic ultraviolet sensors

et al. 2022

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In the quest for emerging in-sensor computing, materials that respond to optical stimuli in conjunction with non-volatile phase transition are highly desired for realizing bioinspired neuromorphic vision components. Here, we report a non-volatile multi-level control of VO2 films by oxygen stoichiometry engineering under ultraviolet irradiation. Based on the reversible regulation of VO2 films using ultraviolet irradiation and electrolyte gating, we demonstrate a proof-of-principle neuromorphic ultraviolet sensor with integrated sensing, memory, and processing functions at room temperature, and also prove its silicon compatible potential through the wafer-scale integration of a neuromorphic sensor array. The device displays linear weight update with optical writing because its metallic phase proportion increases almost linearly with the light dosage. Moreover, the artificial neural network consisting of this neuromorphic sensor can extract ultraviolet information from the surrounding environment, and significantly improve the recognition accuracy from 24% to 93%. This work provides a path to design neuromorphic sensors and will facilitate the potential applications in artificial vision systems.

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Spatiotemporal characterization of the field-induced insulator-to-metal transition

Cited by 75 publications

References 49 publications

Translational Control of COVID-19 and Its Therapeutic Implication

Translational Control of COVID-19 and Its Therapeutic Implication

Quantum materials for energy-efficient neuromorphic computing

Photo-induced non-volatile VO2 phase transition for neuromorphic ultraviolet sensors

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