Spatiotemporal patterns and relationships among the diet, biochemistry, and exposure to flame retardants in an apex avian predator, the peregrine falcon

Fernie, Kim J.; Chabot, Dominique; Champoux, Louise; Brimble, Samantha; Alaee, Mehran; Marteinson, Sarah C.; Chen, Da; Palace, Vince; Bird, David M.; Letcher, Robert J.

doi:10.1016/j.envres.2017.05.035

Cited by 40 publications

(46 citation statements)

References 61 publications

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“…Changes in hippocampal volume, such as an inflammation response, could affect spatial memory, altering the ability of predators such as kestrels to navigate. The flame retardant BEH-TEBP is widely manufactured and used (Covaci et al 2011) and is widely detectable including in wildlife tissues (Lam et al 2009) and birds (Sagerup et al 2010;Gentes et al 2012;Guerra et al 2012;Lazarus et al 2016;Fernie et al 2017), suggesting the likelihood of potentially similar effects in wild birds. In addition to determining whether BEH-TEBP crosses the blood-brain barrier (BEH-TEBP levels in the brain were not measured in the present study), future research should examine the potential impacts of BEH-TEBP on bird behavior, specifically on movement in the wild and on spatial memory, while concurrently measuring neuroanatomy in the same individuals.…”

Section: Discussionmentioning

confidence: 99%

Sex‐specific responses in neuroanatomy of hatchling American kestrels in response to embryonic exposure to the flame retardants bis(2‐ethylhexyl)‐2,3,4,5‐tetrabromophthalate and 2‐ethylhexyl‐2,3,4,5‐tetrabromobenzoate

Guigueno

Karouna‐Renier

Henry

et al. 2018

Enviro Toxic and Chemistry

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Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB), flame retardant components of FireMaster 550® and 600® have been detected in tissues of wild birds. To address the paucity of information regarding potential impacts of flame retardants on the brain, brain volume regions of hatchling American kestrels (Falco sparverius) were evaluated following in ovo injection at embryonic day 5 with safflower oil or to 1 of 3 doses of either BEH-TEBP (13, 64, or 116 μg/g egg) or EH-TBB (12, 60, or 149 μg/g egg). The doses for both chemicals reflected concentrations reported in wild birds. The volumes of the hippocampus and telencephalon and volumetric differences between left and right hemispheres were measured in hatchlings (embryonic day 28). A sex-specific effect of BEH-TEBP on relative hippocampus volume was evident: the hippocampus was significantly enlarged in high-dose females compared to control females but smaller in low-dose females than the other females. There was no significant effect of EH-TBB on hippocampus volume in female kestrel hatchlings or of either chemical in male hatchlings and no effects of these concentrations of EH-TBB or BEH-TEBP on telencephalon volume or the level of symmetry between the hemispheres of the brain. In sum, embryonic exposure of female kestrels to these BEH-TEBP concentrations altered hippocampus volume, having the potential to affect spatial memory relating to ecologically relevant behavior such as prey capture, predator avoidance, and migration. Environ Toxicol Chem 2018;37:3032-3040. © 2018 SETAC.

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Section: Discussionmentioning

confidence: 99%

Sex‐specific responses in neuroanatomy of hatchling American kestrels in response to embryonic exposure to the flame retardants bis(2‐ethylhexyl)‐2,3,4,5‐tetrabromophthalate and 2‐ethylhexyl‐2,3,4,5‐tetrabromobenzoate

Guigueno

Karouna‐Renier

Henry

et al. 2018

Enviro Toxic and Chemistry

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“…The environmental matrix detection and quantification of OPEs has motivated research measuring OPEs in biota residues, including some marine species (See Table 1-1). In summary, total OPE concentrations have been reported as high as 15 000 ng/g in global fish surveys (Hou et al, 2016;Sundkvist et al, 2010 (Eulaers et al, 2014;Fernie et al, 2017;Hallanger et al, 2015;Mcgoldrick et al, 2014). Additionally, low concentrations of OPEs have been detected in Western and Southern Hudson Bay polar bear liver and adipose tissue (Letcher et al, 2017b).…”

Section: List Of Abbreviationsmentioning

confidence: 99%

“…OPEs demonstrate many other negative health effects. These range from cellular cytotoxicity (Porter et al, 2014;Su et al, 2014), cardiotoxicity in the zebra fish model species (Du et al, 2015;Isales et al, 2015), neurotoxicity (Pei et al, 2015;Yuan et al, 2016), endocrine disruption (Chen et al, 2015a;Kojima et al, 2016Kojima et al, , 2013Ma et al, 2015;Schang et al, 2016;Suzuki et al, 2013), oxidative stress (Chen et al, 2015a(Chen et al, , 2015bSchang et al, 2016), thyroid concerns (Fernie et al, 2017;Hill et al, 2018a), and carcinogenicity (Hoffman et al, 2017). While this is a very brief list of general toxicity and health related research, there is substantial evidence that negative effects of OPEs require further investigation into the toxicokinetic parameters, especially in terms of groups of structurally similar OPEs.…”

Section: Adverse Effects Of Opesmentioning

confidence: 99%

“…OPEs have been reported in numerous environmental samples such as in air, wastewater effluent, household dust, sediment, and biota (Cristale et al, 2016;Fernie et al, 2017;Greaves et al, 2016a;Kim et al, 2013;Möller et al, 2012;Su et al, 2015a).…”

Section: Introductionmentioning

confidence: 99%

“…OPE exposure for Arctic biota is a concern and there is little toxicological data available. From the few monitoring studies that have been reported, top Arctic predators including polar bears (Ursus maritimus) and their main prey source, ringed seal (Pusa hispida), have consistently low concentrations of OPEs in various storage tissues (Eulaers et al, 2014;Fernie et al, 2017;Hallanger et al, 2015;Letcher et al, 2018;Muir et al, 2013;Strobel et al, 2018). This is proving to be largely due to rapid metabolism of OPEs as has been shown in vitro for rat, human, herring gull, polar bear, and ringed seal in assays using hepatic microsomes (Sasaki et al, 1984;Strobel et al, 2017;Su et al, 2016a;van den Eede et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Fate of organophosphate esters (OPEs) in East Greenland polar bears and their ringed seal prey using in vitro lab- and field-based studies to investigate metabolism

Strobel¹

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Arctic wildlife can be exposed to environmental chemical contamination due to longrange transport and subsequent deposition. Organophosphate esters (OPEs) are emerging chemicals of concern, found at high concentration in Arctic abiota but low levels in biota, including in polar bear and ringed seal adipose tissue currently under study. OPE metabolism was investigated in East Greenland polar bears and ringed seals using enzymatically-active liver microsomes. Organophosphate triester metabolism rate and extent were found to be greater in polar bears than ringed seals. Chemical structure and physical properties of OPEs affected metabolism; notably, bulkier, alkyl-substituted triphenyl phosphates had decreased metabolism in both species. The degradation of OPEs with aryl and alkyl substituents occurred at a greater rates in polar bears and ringed seals respectively. The structure-dependent metabolism of eleven OPEs have important implications for regulatory and risk assessments, as some compounds have little to no toxicokinetics data available in the current literature.

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Bioaccumulation of Selected Halogenated Organic Flame Retardants in Lake Ontario

Kurt-Karakuş

Muir

Jourdan

et al. 2019

Environ Toxicol Chem

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The trophic magnification of polybrominated diphenyl ethers (PBDEs) and selected nonlegacy halogenated organic compounds (HOCs) was determined in the food web of Lake Ontario (ON, Canada). In all, 28 Br3‐Br8‐PBDEs and 24 HOCs (10 of which had not been targeted previously) were analyzed. Average concentrations of Σ28PBDEs in fish ranged between 79.7 ± 54.2 ng/g lipid weight in alewife (Alosa pseudoharengus) and 815 ± 695 ng/g lipid weight in lake trout (Salvelinus namaycush). For invertebrates, concentrations were between 13.4 ng/g lipid weight (net plankton; >110 μm) and 41.9 ng/g lipid weight in Diaporeia (Diaporeia hoyi). Detection frequency (DF) for HOCs was highest for anti‐Dechlorane Plus (anti‐DDC‐CO), 1,3‐diiodobenzene (1,3‐DiiB), tribromo‐methoxy‐methylbenzene (ME‐TBP), allyl 2,4,6‐tribromophenyl ether (TBP‐AE), pentabromocyclododecene (PBCYD), α+β‐tetrabromocylcooctane (TBCO), 2‐bromoallyl 2,4,6‐tribromophenyl ether (BATE), and pentabromotoluene (PBT; DF for all = 100% in lake trout). Tetrabromoxylene (TBX), dibromopropyl 2,4,6‐tribromophenyl ether (TBP‐DBPE), and syn‐DDC‐CO were also frequently detected in trout (DF = 70–78%), whereas 2,3,4,5,6‐pentabromoethyl benzene (PBEB) was detected only in plankton. Several HOCs were reported in aquatic biota in the Great Lakes (USA/Canada) for the first time in the present study, including PBCYD, 1,3DiiB, BATE, TBP‐DBPE, PBT, α + β‐TBCO, and ME‐TBP. The Br4‐6‐BDEs (−47, −85, −99, −100, −153, and −154) all had prey‐weighted biomagnification factors (BMFPW) values >6, whereas BMFPW values for Br7‐8‐BDEs were <1. The highest BMFPW values of non‐PBDEs were for TBP‐DBPE (10.6 ± 1.34) and ME‐TBP (4.88 ± 0.60), whereas TBP‐AE had a BMFPW value of <1. Significant (p ≤ 0.05) trophic magnification factors (TMFs), both positive and negative, were found for Br4‐8‐BDEs (BDE 196 = 0.4; BDE 154 = 9.5) and for bis(2,4,6‐tribromophenoxy)ethane (BTBPE; 0.53), PBCYD (1.8), 1,3‐DiiB (0.33), and pentabromobenzene (PBB; 0.25). Food chain length was found to have a significant influence on the TMF values. Environ Toxicol Chem 2019;38:1198–1210. © 2019 SETAC

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Spatiotemporal patterns and relationships among the diet, biochemistry, and exposure to flame retardants in an apex avian predator, the peregrine falcon

Cited by 40 publications

References 61 publications

Sex‐specific responses in neuroanatomy of hatchling American kestrels in response to embryonic exposure to the flame retardants bis(2‐ethylhexyl)‐2,3,4,5‐tetrabromophthalate and 2‐ethylhexyl‐2,3,4,5‐tetrabromobenzoate

Sex‐specific responses in neuroanatomy of hatchling American kestrels in response to embryonic exposure to the flame retardants bis(2‐ethylhexyl)‐2,3,4,5‐tetrabromophthalate and 2‐ethylhexyl‐2,3,4,5‐tetrabromobenzoate

Fate of organophosphate esters (OPEs) in East Greenland polar bears and their ringed seal prey using in vitro lab- and field-based studies to investigate metabolism

Bioaccumulation of Selected Halogenated Organic Flame Retardants in Lake Ontario

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