Spatiotemporal propagation patterns of generalized ictal spikes in childhood absence epilepsy

Kokkinos, Vasileios; Koupparis, Andreas; Koutroumanidis, Michalis; Kostopoulos, George

doi:10.1016/j.clinph.2017.05.021

Cited by 12 publications

(7 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are a large body of articles on the mechanisms of initiation and generalization of discharges (8, 11, 19, 21, 33), with relatively few articles regarding the termination processes. To the best of our knowledge, this study is the first investigation to directly assess the source localization and predominant EC network of seizure termination using a multi-frequency analysis with MEG in CAE patients.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Neuromagnetic Network Changes of Seizure Termination in Absence Epilepsy: A Magnetoencephalography Study

Jiang

Xiang

et al. 2019

Front. Neurol.

View full text Add to dashboard Cite

Objective: With increasing efforts devoted to investigating the generation and propagation mechanisms of spontaneous spike and wave discharges (SWDs), little attention has been paid to network mechanisms associated with termination patterns of SWDs to date. In the current study, we aimed to identify the frequency-dependent neural network dynamics during the offset of absence seizures. Methods: Fifteen drug-naïve patients with childhood absence epilepsy (CAE) were assessed with a 275-Channel Magnetoencephalography (MEG) system. MEG data were recorded during and between seizures at a sampling rate of 6,000 Hz and analyzed in seven frequency bands. Source localization was performed with accumulated source imaging. Granger causality analysis was used to evaluate effective connectivity networks of the entire brain at the source level. Results: At the low-frequency (1–80 Hz) bands, activities were predominantly distributed in the frontal cortical and parieto–occipito–temporal junction at the offset transition periods. The high-frequency oscillations (HFOs, 80–500 Hz) analysis indicated significant source localization in the medial frontal cortex and deep brain areas (mainly thalamus) during both the termination transition and interictal periods. Furthermore, an enhanced positive cortico–thalamic effective connectivity was observed around the discharge offset at all of the seven analyzed bands, the direction of which was primarily from various cortical regions to the thalamus. Conclusions: Seizure termination is a gradual process that involves both the cortices and the thalamus in CAE. Cortico–thalamic coupling is observed at the termination transition periods, and the cerebral cortex acts as the driving force.

show abstract

Section: Discussionmentioning

confidence: 99%

Dynamic Neuromagnetic Network Changes of Seizure Termination in Absence Epilepsy: A Magnetoencephalography Study

Jiang

Xiang

et al. 2019

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…On electroencephalography (EEG), seizures are characterized by a highly recognizable pattern of generalized (bilateral, symmetric, and synchronous) 3-Hz spike and wave discharges (SWDs) ( Kessler and McGinnis, 2019 ). However, an increasing number of studies have found that CAE was more likely to have focal brain origins that were responsible for absence seizures ( Westmijse et al, 2009 ; Kim et al, 2011 ; Tenney et al, 2013 ; Rozendaal et al, 2016 ; Kokkinos et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Multifrequency Dynamics of Cortical Neuromagnetic Activity Underlying Seizure Termination in Absence Epilepsy

Sun

Gao

Miao

et al. 2020

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Purpose This study aimed to investigate the spectral and spatial signatures of neuromagnetic activity underlying the termination of absence seizures. Methods Magnetoencephalography (MEG) data were recorded from 18 drug-naive patients with childhood absence epilepsy (CAE). Accumulated source imaging (ASI) was used to analyze MEG data at the source level in seven frequency ranges: delta (1–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), beta (12–30 Hz), gamma (30–80 Hz), ripple (80–250 Hz), and fast ripple (250–500 Hz). Result In the 1–4, 4–8, and 8–12 Hz ranges, the magnetic source during seizure termination appeared to be consistent over the ictal period and was mainly localized in the frontal cortex (FC) and parieto-occipito-temporal junction (POT). In the 12–30 and 30–80 Hz ranges, a significant reduction in source activity was observed in the frontal lobe during seizure termination as well as a decrease in peak source strength. The ictal peak source strength in the 1–4 Hz range was negatively correlated with the ictal duration of the seizure, whereas in the 30–80 Hz range, it was positively correlated with the course of epilepsy. Conclusion The termination of absence seizures is associated with a dynamic neuromagnetic process. Frequency-dependent changes in the FC were observed during seizure termination, which may be involved in the process of neural network interaction. Neuromagnetic activity in different frequency bands may play different roles in the pathophysiological mechanism during absence seizures.

show abstract

“…Childhood absence epilepsy (CAE) is a common type of genetic generalized epilepsies . Typical clinical manifestations include gazing, transient loss of consciousness, and sudden stop of motion, and they are resolved generally within 30 seconds . Electroencephalography shows generalized 2.5‐3.5 Hz spike‐and‐wave discharges.…”

Section: Introductionmentioning

confidence: 99%

The absence of NIPA2 enhances neural excitability through BK (big potassium) channels

et al. 2019

View full text Add to dashboard Cite

Summary Aim To reveal the pathogenesis and find the precision treatment for the childhood absence epilepsy (CAE) patients with NIPA2 mutations. Methods We performed whole‐cell patch‐clamp recordings to measure the electrophysiological properties of layer V neocortical somatosensory pyramidal neurons in wild‐type (WT) and NIPA2 ‐knockout mice. Results We identified that layer V neocortical somatosensory pyramidal neurons isolated from the NIPA2 ‐knockout mice displayed higher frequency of spontaneous and evoked action potential, broader half‐width of evoked action potential, and smaller currents of BK channels than those from the WT mice. NS11021, a specific BK channel opener, reduced neuronal excitability in the NIPA2 ‐knockout mice. Paxilline, a selective BK channel blocker, treated WT neurons and could simulate the situation of NIPA2 ‐knockout group, thereby suggesting that the absence of NIPA2 enhanced the excitability of neocortical somatosensory pyramidal neurons by decreasing the currents of BK channels. Zonisamide, an anti‐epilepsy drug, reduced action potential firing in NIPA2 ‐knockout mice through increasing BK channel currents. Conclusion The results indicate that the absence of NIPA2 enhances neural excitability through BK channels. Zonisamide is probably a potential treatment for NIPA2 mutation‐induced epilepsy, which may provide a basis for the development of new treatment strategies for epilepsy.

show abstract

Spatiotemporal propagation patterns of generalized ictal spikes in childhood absence epilepsy

Cited by 12 publications

References 43 publications

Dynamic Neuromagnetic Network Changes of Seizure Termination in Absence Epilepsy: A Magnetoencephalography Study

Dynamic Neuromagnetic Network Changes of Seizure Termination in Absence Epilepsy: A Magnetoencephalography Study

Multifrequency Dynamics of Cortical Neuromagnetic Activity Underlying Seizure Termination in Absence Epilepsy

The absence of NIPA2 enhances neural excitability through BK (big potassium) channels

Contact Info

Product

Resources

About