Spatiotemporal remodeling of embryonic aortic arch: stress distribution, microstructure, and vascular growth in silico

Lashkarinia, S Samaneh; Çoban, Gürsan; Ermek, Erhan; Celik, Merve; Pekkan, Kerem

doi:10.1007/s10237-020-01315-6

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…While circumferential residual stress is 0.17 kPa at HH18, it almost doubles and becomes 0.33 kPa at stage 24. Although the increase in radial direction is not as high as in other directions, there is about a 0.1 kPa increase between the two stages studied [45].…”

Section: Stress Distribution and Anisotropymentioning

confidence: 61%

“…Uniaxial/biaxial tensile testing [30] Optical coherence tomography [31,32] Invasive/noninvasive residual stress experiments [33] Epifluorescence/fluoroscopy [34] In vivo pressurization [35] Microscopy [34,36] Optical stretching and optical tweezers [37] Magnetic resonance imaging [18] Finite element modeling (FEM) [3] Echocardiograph [38,39] Cantilever based technologies [29] Confocal/two-photon microscopy [19] Strain energy and Gasser-Ogden-Holzapfel models [40] Scanning electron microscopy [41,42] Cuts [43] Histology [44] Micropipette aspiration with servo-null pressure measurements [45] Digital camera…”

Section: Refmentioning

confidence: 99%

“…For example, the Ogden material model [51] is commonly used, as employed by Von Dassow et al [52] and Yao et al [8] to model Xenopus laevis embryonic tissue and looping heart tissue in chick embryo, respectively. A simplified form of the Ogden material model is the neo-Hookean strain energy function, which was used in our recent work to characterize the growth of aortic arch tissue at early embryonic stages of the chick embryo [45].…”

Section: Beads [910] Radiologymentioning

confidence: 99%

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Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

Siddiqui

Dogru

Lashkarinia

et al. 2022

JCDD

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During embryonic development, changes in the cardiovascular microstructure and material properties are essential for an integrated biomechanical understanding. This knowledge also enables realistic predictive computational tools, specifically targeting the formation of congenital heart defects. Material characterization of cardiovascular embryonic tissue at consequent embryonic stages is critical to understand growth, remodeling, and hemodynamic functions. Two biomechanical loading modes, which are wall shear stress and blood pressure, are associated with distinct molecular pathways and govern vascular morphology through microstructural remodeling. Dynamic embryonic tissues have complex signaling networks integrated with mechanical factors such as stress, strain, and stiffness. While the multiscale interplay between the mechanical loading modes and microstructural changes has been studied in animal models, mechanical characterization of early embryonic cardiovascular tissue is challenging due to the miniature sample sizes and active/passive vascular components. Accordingly, this comparative review focuses on the embryonic material characterization of developing cardiovascular systems and attempts to classify it for different species and embryonic timepoints. Key cardiovascular components including the great vessels, ventricles, heart valves, and the umbilical cord arteries are covered. A state-of-the-art review of experimental techniques for embryonic material characterization is provided along with the two novel methods developed to measure the residual and von Mises stress distributions in avian embryonic vessels noninvasively, for the first time in the literature. As attempted in this review, the compilation of embryonic mechanical properties will also contribute to our understanding of the mature cardiovascular system and possibly lead to new microstructural and genetic interventions to correct abnormal development.

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Section: Stress Distribution and Anisotropymentioning

confidence: 61%

Section: Refmentioning

confidence: 99%

Section: Beads [910] Radiologymentioning

confidence: 99%

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Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

Siddiqui

Dogru

Lashkarinia

et al. 2022

JCDD

Self Cite

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“…Blood flow dynamics (hemodynamics) affect the development of the heart [15,16] and aortic arches [17][18][19] leading to congenital heart defects. As the heart and vasculature develop, they are very sensitive to blood flow conditions.…”

Section: Early Perturbed Flow and Tofmentioning

confidence: 99%

Fetal Blood Flow and Genetic Mutations in Conotruncal Congenital Heart Disease

Dyer

Rugonyi

2021

JCDD

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In congenital heart disease, the presence of structural defects affects blood flow in the heart and circulation. However, because the fetal circulation bypasses the lungs, fetuses with cyanotic heart defects can survive in utero but need prompt intervention to survive after birth. Tetralogy of Fallot and persistent truncus arteriosus are two of the most significant conotruncal heart defects. In both defects, blood access to the lungs is restricted or non-existent, and babies with these critical conditions need intervention right after birth. While there are known genetic mutations that lead to these critical heart defects, early perturbations in blood flow can independently lead to critical heart defects. In this paper, we start by comparing the fetal circulation with the neonatal and adult circulation, and reviewing how altered fetal blood flow can be used as a diagnostic tool to plan interventions. We then look at known factors that lead to tetralogy of Fallot and persistent truncus arteriosus: namely early perturbations in blood flow and mutations within VEGF-related pathways. The interplay between physical and genetic factors means that any one alteration can cause significant disruptions during development and underscore our need to better understand the effects of both blood flow and flow-responsive genes.

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Computational modeling of vascular growth in patient-specific pulmonary arterial patch reconstructions

Lashkarinia

Çoban

Kose

et al. 2021

Journal of Biomechanics

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Spatiotemporal remodeling of embryonic aortic arch: stress distribution, microstructure, and vascular growth in silico

Cited by 7 publications

References 39 publications

Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

Fetal Blood Flow and Genetic Mutations in Conotruncal Congenital Heart Disease

Computational modeling of vascular growth in patient-specific pulmonary arterial patch reconstructions

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