2020
DOI: 10.1101/2020.07.20.212399
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Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states

Abstract: One of the central challenges in the field of allo-immunity is deciphering the mechanisms driving T cells to infiltrate and subsequently occupy target organs to cause disease. The act of CD8-dominated T cell infiltration is critical to acute graft-versus-host disease (aGVHD), wherein donor T cells become activated, tissue-infiltrating and highly cytotoxic, causing wide-spread tissue damage after allogeneic hematopoietic stem cell transplant (allo-HCT). However, in human and non-human primate studies, deconvolv… Show more

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