“…In this sense, obesity, which kills 2.8 million people/year worldwide, is a major component of MS, being a direct precursor of (a) dyslipidemia (2.6 million deaths/year, globally); (b) NAFLD (≤1 million deaths/year, global); (c) hypertension (9.4 million deaths/year, global); (d) cardiovascular diseases (17.9 million deaths/year, globally); (e) insulin resistance and type 2 diabetes (≅1.5 million deaths/year, global) ( Sixty-sixth World Health Assembly., 2013 , WHO, 2021 , World Health Organization (WHO)., 2016 , World Health Organization., 2021 ). MS and its associated comorbidities can be alleviated with increased physical activity, moderate alcohol exposure, and non-smoking ( de Oliveira et al, 2021 ). In addition, dietary changes, such as nutrition rich in polyphenols, can modulate epigenetics to control MS and its associated comorbidities.…”