2009
DOI: 10.1002/jmri.21985
|View full text |Cite
|
Sign up to set email alerts
|

Special issue: Nephrogenic systemic fibrosis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
13
0

Year Published

2009
2009
2016
2016

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 10 publications
(13 citation statements)
references
References 26 publications
0
13
0
Order By: Relevance
“…Choice of contrast agent appears to have a great effect on the occurrence of NSF: there is growing evidence that NSF is associated with MRI contrast agents that exhibit low kinetic inertness, specifically Gd 3+ -complexes of open chain ligands derived from DTPA. So far, NSF has not been confirmed in patients who received macrocyclic contrast agents 287–288. The exceptionally high kinetic inertness of Gd 3+ complexes of DOTA and DOTA-like ligands in general is the result of the preorganized, conformationally rigid structure of the macrocyclic cyclen backbone.…”
Section: Chemical Exchange Saturation Transfer (Cest)mentioning
confidence: 99%
See 1 more Smart Citation
“…Choice of contrast agent appears to have a great effect on the occurrence of NSF: there is growing evidence that NSF is associated with MRI contrast agents that exhibit low kinetic inertness, specifically Gd 3+ -complexes of open chain ligands derived from DTPA. So far, NSF has not been confirmed in patients who received macrocyclic contrast agents 287–288. The exceptionally high kinetic inertness of Gd 3+ complexes of DOTA and DOTA-like ligands in general is the result of the preorganized, conformationally rigid structure of the macrocyclic cyclen backbone.…”
Section: Chemical Exchange Saturation Transfer (Cest)mentioning
confidence: 99%
“…Free Gd 3+ due to the dissociation of the contrast agent has also been implicated in Nephrogenic Systemic Fibrosis (NSF) although it has also been suggested that the intact complexes may play a role in triggering NSF. NSF is a systemic fibrosing disorder which characteristically exhibits fibrosis of the skin and the connective tissues, but it also affects other organs 285287. It is important to emphasize that NSF is exceedingly rare and only affects a small percentage of patients with severely compromised renal function.…”
Section: Chemical Exchange Saturation Transfer (Cest)mentioning
confidence: 99%
“…They may also have very long plasma half-lives if they are too large (> 50 KDa) for renal clearance and are not substrates for reticuloendothelial (RES) clearance. This can have significance to imaging agents, which rely on clearance to increase conspicuity and can have off target toxicities if the pharmacokinetic AUC is large, such as Gadolinium-induced nephrogenic systemic fibrosis, NSF [42, 72]. Although there is a temptation to combine imaging and therapeutic agents to target receptors, this may not always be appropriate as therapeutics are often antagonists with very high affinities, yet imaging agents are often better as agonists, as they can induce receptor recycling and hence, amplification of signal [73].…”
Section: Extracellular Targetsmentioning
confidence: 99%
“…30 Gadolinium is a highly toxic rare earth metal in the unbounded form. [32][33][34][35][36][37] When the Gd(III) ions are chelated, the toxicity can be enormously reduced and the LD 50 increases 100-fold aer chelation. [32][33][34][35][36][37] When the Gd(III) ions are chelated, the toxicity can be enormously reduced and the LD 50 increases 100-fold aer chelation.…”
Section: Introductionmentioning
confidence: 99%