Special Issue “Viral Infections in Developing Countries”

Campos, Fabrício Souza; Arruda, Luciana Barros de; Fonseca, Flávio Guimarães da

doi:10.3390/v14020405

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Viral infection has now become the biggest global concern for healthcare professionals because of the increasing incidence of morbidity and mortality. Viral infectious illnesses are becoming a severe hazard to human health in both developing and developed countries [ 1 ], killing 1 million people each year. Human immunodeficiency virus (HIV), hepatitis virus subtypes A, B, and C (HAV, HBV, and HCV), herpes simplex virus (HSV), influenza virus, Dengue virus, Ebola virus, and other viruses such as monkeypox/mpox virus have been affecting human health for decades [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions

et al. 2023

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Many of the medicinally active molecules in the flavonoid class of phytochemicals are being researched for their potential antiviral activity against various DNA and RNA viruses. Quercetin is a flavonoid that can be found in a variety of foods, including fruits and vegetables. It has been reported to be effective against a variety of viruses. This review, therefore, deciphered the mechanistic of how Quercetin works against some of the deadliest viruses, such as influenza A, Hepatitis C, Dengue type 2 and Ebola virus, which cause frequent outbreaks worldwide and result in significant morbidity and mortality in humans through epidemics or pandemics. All those have an alarming impact on both human health and the global and national economies. The review extended computing the Quercetin-contained natural recourse and its modes of action in different experimental approaches leading to antiviral actions. The gap in effective treatment emphasizes the necessity of a search for new effective antiviral compounds. Quercetin shows potential antiviral activity and inhibits it by targeting viral infections at multiple stages. The suppression of viral neuraminidase, proteases and DNA/RNA polymerases and the alteration of many viral proteins as well as their immunomodulation are the main molecular mechanisms of Quercetin’s antiviral activities. Nonetheless, the huge potential of Quercetin and its extensive use is inadequately approached as a therapeutic for emerging and re-emerging viral infections. Therefore, this review enumerated the food-functioned Quercetin source, the modes of action of Quercetin for antiviral effects and made insights on the mechanism-based antiviral action of Quercetin.

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Section: Introductionmentioning

confidence: 99%

Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions

et al. 2023

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“…Human immunodeficiency virus (HIV) uses the host cell‘s DNA for its growth and manifestation and causes AIDS. Many viruses evade immune responses and cause chronic infections [14–16] . Details of viral infections are depicted in Table 2.…”

Section: Pathogenesismentioning

confidence: 99%

“…Many viruses evade immune responses and cause chronic infections. [14][15][16] Details of viral infections are depicted in Table 2.…”

Section: Pathogenesismentioning

confidence: 99%

Synthesis and Antiviral Efficacy of Pyrimidine Analogs Targeting Viral Pathways

Basha¹,

Chandana²

2023

ChemistrySelect

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To date, viruses are known to cause chronic to acute pathogenesis. Nevertheless, antiviral drugs have been known for their medicinal applications for the last few decades to treat infections caused by these pathogens. Despite advancements in the field of vaccination and antiviral drugs, there is a need for a molecule that can eradicate or control viral infection without getting resistance from pathogens will be a real challenge. This review covers possible ways to treat viral infections with pyrimidine and its mimics compared to known antiviral drugs. A comprehensive study of the report accomplished synthetic routes of pyrimidine analogs and their target‐specific antiviral potential. The present review article covers literature from 2018 to 2022.

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Idiopathic collapsing glomerulopathy is associated with APOL1 high-risk genotypes or Mendelian variants in most affected individuals in a highly admixed population

Neves,

Watanabe,

Watanabe

et al. 2024

Kidney International

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Special Issue “Viral Infections in Developing Countries”

Abstract: Viral infections by endemic, emerging, and reemerging viruses are constantly challenging public health systems and health policies all over the world [...]

Cited by 4 publications

References 29 publications

Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions

Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions

Synthesis and Antiviral Efficacy of Pyrimidine Analogs Targeting Viral Pathways

Idiopathic collapsing glomerulopathy is associated with APOL1 high-risk genotypes or Mendelian variants in most affected individuals in a highly admixed population

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