Specialised lipid mediators and their targets

Crean, Daniel; Godson, Catherine

doi:10.1016/j.smim.2015.05.002

Cited by 23 publications

(14 citation statements)

References 121 publications

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“…NF-κB DNA binding activity further increased at 24 and 48 h after in ammatory stimulation in the presence of IκBα protein [34]. Myeloid cells represent a major target for LXA4 and re ect the attenuation of NF-κB activity [35][36][37]. Therefore, n-6 PUFA participates in the resolution of in ammation [38].…”

Section: Discussionmentioning

confidence: 99%

The diets of sows with fish oil might decrease the oxidative stress and inflammatory response in sows, but increase the susceptibility to inflammatory response in their offspring

Luo

Zhang

et al. 2020

Preprint

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Backgroup: This aim of this study was to investigate that the effect of supplement maternal diet with fish oil on the oxidative stress and inflammatory response of sows and their offspring.Methods: Twelve sows were divided into two groups. Sows were fed soybean oil diet (SD) or soybean oil + fish oil diet (FD) from gestating to lactating period. The blood samples of lactating sows were collected. At the age of 14 days, one piglet was selected from each litter. After the blood was collected from the anterior vena cava, LPS was injected into the neck muscle. The blood was collected 5 hours after LPS injection. At 48h after LPS injection, blood and liver samples were collected.Results: Maternal fish oil supplementation improved the health of sows by increasing the level of HDL-C and decreasing the levels of AKP and TNF-α in the plasma of sow (P<0.05), and induced a positive effect on litter immune status associated with a modification of both IgG in the colostrum and IL-10 in the milk(P<0.05).In addition, antioxidant capacity in piglets increased by improving the level of GSH-Px and T-AOC (P<0.05) in the plasma of piglets 48h after LPS challenged. Meanwhile, the expression of GSH-Px mRNA and p-ERK protein in the livers of piglets was inhibited (P<0.05). However, in FD group, the level of IL-1β and IL-6 in the plasma of piglets were significantly higher before and after LPS challenged (P<0.05). The expression of NF-κB mRNA and p-IκB-α protein was increased in the liver of piglets (P<0.05). Conclusion: These results indicated that the diet of sow with fish oil might decrease the oxidative stress and inflammatory response in sows and enhance the antioxidative ability in their progenies, but might increase the susceptibility to inflammatory response in progenies.

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Section: Discussionmentioning

confidence: 99%

The diets of sows with fish oil might decrease the oxidative stress and inflammatory response in sows, but increase the susceptibility to inflammatory response in their offspring

Luo

Zhang

et al. 2020

Preprint

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“…The inflammatory response to injured tissues involves the liberation of chemical signals in the form of chemokines, cytokines, and lipid-derived mediators by the cells of the innate immune system; initially the PMNs, and then macrophages, mast cells, and endothelial cells, ultimately resulting in an inflammatory defence to protect the affected cells (10). Modulation of the initiation phase of acute inflammation is controlled by a category of lipid mediators such as PGs, LTs, and eicosanoids that are constituted from arachidonic acid (AA, omega-6) and have the efficiency to regulate endothelial permeability and PMN infiltration (11).…”

Section: : Role Of Lipid Mediators In Inflammatory Responsesmentioning

confidence: 99%

“…The resolution step is controlled by the local release of different SPMs such as lipoxins, resolvins, protectins, and maresins, collectively known as theSPMs (15)(16). Thus, the biosynthesis of these mediators depends on the initial pro-inflammatory stimuli that trigger compensatory mechanisms for the resolution of inflammation (10).…”

Section: : Role Of Lipid Mediators In Inflammatory Responsesmentioning

confidence: 99%

Resolvins: Emerging Players in Autoimmune and Inflammatory Diseases

Abdolmaleki

Kovanen

Mardani

et al. 2019

Clinic Rev Allerg Immunol

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Specialized Proresolving Mediators (SPMs) including resolvins are metabolic products of omega-3 fatty acids, and they are synthesized during the initial phases of acute inflammatory responses to promote the resolution of inflammation. Resolvins are produced for termination of neutrophil infiltration, stimulation of the clearance of apoptotic cells by macrophages, and promotion of tissue remodeling and homeostasis. Metabolic dysregulation due to either uncontrolled activity of pro-inflammatory responses or to inefficient resolution of inflammation results in chronic inflammation and may also lead to atherosclerosis or other chronic diseases. The pathogenesis of such diseases involves a complex interplay between the immune system, environmental factors (non-infectious or infectious), and critically depends on individual susceptibility to such factors. The diseases include, for example, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, vasculitis, inflammatory bowel diseases, and type 1 diabetes mellitus. In the present review, resolvins and their roles in the resolution of inflammation, as well as the role of these mediators as potential therapeutic agents to counteract specific chronic diseases are discussed.

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“…The variants TRIM5 and PROCR ( p = 6.8 × 10 −12 ) reaching GWAs significance are related to inflammation, which are relatively newly identified, show convergence between biological and genetic determinants of CVD and add to this inflammatory hypothesis ( 18 , 20 ). An alternative therapeutic paradigm to anti-inflammatory modalities may be efforts to mimic the resolution of inflammation using specialized lipid mediators and their targets ( 53 – 55 ).…”

Section: Olfactory Signaling Influences Trim5 and Is Also Linked To Amentioning

confidence: 99%

Exploring Coronary Artery Disease GWAs Targets With Functional Links to Immunometabolism

Hughes

Lenighan

Godson

et al. 2018

Front. Cardiovasc. Med.

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Finding genetic variants that cause functional disruption or regulatory change among the many implicated GWAs variants remains a key challenge to translating the findings from GWAs to therapeutic treatments. Defining the causal mechanisms behind the variants require functional screening experiments that can be complex and costly. Prioritizing variants for functional characterization using techniques that capture important functional and regulatory elements can assist this. The genetic architecture of complex traits such as cardiovascular disease and type II diabetes comprise an enormously large number of variants of small effect contributing to heritability and spread throughout the genome. This makes it difficult to distinguish which variants or core genes are most relevant for prioritization and how they contribute to the regulatory networks that become dysregulated leading to disease. Despite these challenges, recent GWAs for CAD prioritized genes associated with lipid metabolism, coagulation and adhesion along with novel signals related to innate immunity, adipose tissue and, vascular function as important core drivers of risk. We focus on three examples of novel signals associated with CAD which affect risk through missense or UTR mutations indicating their potential for therapeutic modification. These variants play roles in adipose tissue function vascular function and innate immunity which form the cornerstones of immuno-metabolism. In addition we have explored the putative, but potentially important interactions between the environment, specifically food and nutrition, with respect to key processes.

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Specialised lipid mediators and their targets

Cited by 23 publications

References 121 publications

The diets of sows with fish oil might decrease the oxidative stress and inflammatory response in sows, but increase the susceptibility to inflammatory response in their offspring

The diets of sows with fish oil might decrease the oxidative stress and inflammatory response in sows, but increase the susceptibility to inflammatory response in their offspring

Resolvins: Emerging Players in Autoimmune and Inflammatory Diseases

Exploring Coronary Artery Disease GWAs Targets With Functional Links to Immunometabolism

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