The diets of sows with fish oil might decrease the oxidative stress and inflammatory response in sows, but increase the susceptibility to inflammatory response in their offspring

Abstract

Backgroup: This aim of this study was to investigate that the effect of supplement maternal diet with fish oil on the oxidative stress and inflammatory response of sows and their offspring.Methods: Twelve sows were divided into two groups. Sows were fed soybean oil diet (SD) or soybean oil + fish oil diet (FD) from gestating to lactating period. The blood samples of lactating sows were collected. At the age of 14 days, one piglet was selected from each litter. After the blood was collected from the anterior vena cava, LPS was injected into the neck muscle. The blood was collected 5 hours after LPS injection. At 48h after LPS injection, blood and liver samples were collected.Results: Maternal fish oil supplementation improved the health of sows by increasing the level of HDL-C and decreasing the levels of AKP and TNF-α in the plasma of sow (P<0.05), and induced a positive effect on litter immune status associated with a modification of both IgG in the colostrum and IL-10 in the milk(P<0.05).In addition, antioxidant capacity in piglets increased by improving the level of GSH-Px and T-AOC (P<0.05) in the plasma of piglets 48h after LPS challenged. Meanwhile, the expression of GSH-Px mRNA and p-ERK protein in the livers of piglets was inhibited (P<0.05). However, in FD group, the level of IL-1β and IL-6 in the plasma of piglets were significantly higher before and after LPS challenged (P<0.05). The expression of NF-κB mRNA and p-IκB-α protein was increased in the liver of piglets (P<0.05). Conclusion: These results indicated that the diet of sow with fish oil might decrease the oxidative stress and inflammatory response in sows and enhance the antioxidative ability in their progenies, but might increase the susceptibility to inflammatory response in progenies.