Speciation of arsenic trioxide penetrates into cerebrospinal fluid in patients with acute promyelocytic leukemia

Kiguchi, Toru; Yoshino, Yuta; Yuan, Bo; Yoshizawa, Seiichiro; T, Kitahara; Akahane, Daigo; Gotoh, Moritaka; Kaise, Toshikazu; Toyoda, Hiroo; Ohyashiki, Kazuma

doi:10.1016/j.leukres.2009.08.001

Cited by 48 publications

(41 citation statements)

References 8 publications

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“…Though the cross blood-brain barrier of ATO was reported [41,42], Knipp et al showed that the peak CSF concentration of ATO was probably not enough for treatment [43]. It has been suggested that CNS relapse may be associated with initial adverse prognostic features (such as high WBC counts, microgranular morphology and BCR3 isoform) [36,44].…”

Section: Discussionmentioning

confidence: 99%

High efficacy of arsenic trioxide plus all-trans retinoic acid based induction and maintenance therapy in newly diagnosed acute promyelocytic leukemia

et al. 2013

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Section: Discussionmentioning

confidence: 99%

High efficacy of arsenic trioxide plus all-trans retinoic acid based induction and maintenance therapy in newly diagnosed acute promyelocytic leukemia

et al. 2013

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“…As a systemic chemotherapy, drugs with high CNS penetrance, such as high dose cytarabine, have been used. It has been confirmed that ATO and its metabolites seem to be capable of crossing the blood–brain barrier (BBB), thus it may be beneficial as a therapeutic agent to control CNS relapse 12. On the other hand, Knipp et al 13 reported that ATO crosses the BBB when administered intravenously, but the concentration in the CSF is probably not adequate to treat meningeal leukaemia.…”

Section: Discussionmentioning

confidence: 99%

Central nervous system relapse in a patient with acute promyelocytic leukaemia: does the risk stratification matter?

et al. 2013

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SUMMARYExtramedullary relapse is an uncommon complication of acute promyelocytic leukaemia (APL). The most common site of extramedullary relapse is the central nervous system (CNS), and the majority of CNS relapses occur in patients with high-risk disease in which white blood cell count at presentation is greater than 10×10 3 /μL. The best management of such patients is still controversial. We describe a 47-year-old man with APL who developed two CNS relapses which were diagnosed through the presence of t(15;17)(q22;q21) on PCR of the cerebrospinal fluid (CSF), despite presenting initially with intermediate-risk disease. We conclude that the intermediate risk group is very heterogeneous and these patients sometimes may behave like high-risk patients. Also, clinicians should take into account symptoms that can be related to CNS relapse in patients with APL and consider lumbar puncture even if radiological imaging does not reveal anything. BACKGROUND

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“…Methylated metabolites are promptly eliminated from the blood and excreted into urine [83]. Aside from methylated species [monomethylarsonous acid (As(III)), monomethylarsonic acid (As(V)), and dimethylarsinic acid], inorganic arsenite (As(III)) was detected in serum, urine samples [85,86], and recently in cerebrospinal fluid of patients with APL [87]. These results are highly relevant to the current and future clinical use of ATO due to the well-known fact that the toxicity of arsenic varies widely as a function of the species [88].…”

Section: Arsenicmentioning

confidence: 99%

Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications

Meermann

Sperling

2012

Anal Bioanal Chem

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Method development and applications of hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals are summarized within this review. Advantages and limitations of the separation modes-high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), and gas chromatography (GC)-as well as the detection modes-inductively coupled plasma-mass spectrometry (ICP-MS) and electrospray ionization-mass spectrometry (ESI-MS)-are discussed. ICP-MS detection is found to be advantageous for the quantification of drugs containing metals and other heteroatoms. The species-independent sensitivity and multielement capabilities of ICP-MS allow it to be used for quantification even when species-specific standards are not available, as well as to determine the stoichiometry in metallodrug-biomolecule interactions. Molecular information that is totally destroyed when ICP is applied as ionization source and is therefore not obtainable via ICP-MS detection can be accessed by the complementary technique of ESI-MS. Speciation analysis combining both elemental and molecular information is therefore a powerful tool for the analysis of metal-based pharmaceuticals and their metabolites in body fluids and other relevant matrices.

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Speciation of arsenic trioxide penetrates into cerebrospinal fluid in patients with acute promyelocytic leukemia

Cited by 48 publications

References 8 publications

High efficacy of arsenic trioxide plus all-trans retinoic acid based induction and maintenance therapy in newly diagnosed acute promyelocytic leukemia

High efficacy of arsenic trioxide plus all-trans retinoic acid based induction and maintenance therapy in newly diagnosed acute promyelocytic leukemia

Central nervous system relapse in a patient with acute promyelocytic leukaemia: does the risk stratification matter?

Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications

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