Species dependency of macrophage activation by bacterial peptidoglycans

Nagao, Shigeki; Harada, Yuji; Okada, Fumito; Akagawa, Shohei; Tanigawa, Yoshinobu

doi:10.1016/0192-0561(91)90318-2

Cited by 6 publications

(7 citation statements)

References 24 publications

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“…The production of IL-1 and PGE2 is well known to be related to inflammatory reactions. There have been several controversial reports on IL-1 production of peritoneal macrophages by stimulation of MDP (16,30). Damais et al reported that thioglycolate-induced peritoneal macrophages from BALB/c mice produced a significant amount of IL-1 in response to MDP (16), which may support the present findings of high IL-1 production from SMNC of BALB/c mice by SEPS stimulation.…”

Section: Precise Mechanisms Of Pg Fractions Especiallysupporting

confidence: 86%

Induction of Acute Arthritis in Mice by Peptidoglycan Derived from Gram‐Positive Bacteria and Its Possible Role in Cytokine Production

Onta

Fujii

et al. 1993

Microbiology and Immunology

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The activities of a water-soluble peptidoglycan fragment derived from Staphylococcus epidermidis (SEPS) were examined as to their role in proliferation of spleen mononuclear cells (SMNC) from various strains of mice, the production of cytokines in vitro, and the induction of an inflammatory reaction in vivo. The proliferation of SMNC from C3H/HeN, C57BL/6, AKR, DBA/ 2, and ddY mice in reaction to SEPS in vitro showed a peak on day 3 and was greater than that of SMNC from BALB/c mice. The cells of SMNC from C3H/HeN mice responsive to SEPS were indicated to be mainly macrophages. A time kinetics experiment showed a coincidence in the proliferation of SMNC in reaction to SEPS and the detection of colony-stimulating factor (CSF) activity. Interleukin 2 (IL-2) activity was not detected during the incubation periods. When SEPS was administered to mice, much stronger mRNA transcripts of granulocyte-macrophage (GM)-CSF were detected in the lungs of C3H/HeN mice than in BALB/c mice. On the other hand, the amounts of IL-1 and PGE2 produced by SMNC of BALB/c mice stimulated by SEPS were greater than those produced in C3H/HeN mice. SEPS was confirmed to induce arthritis in BALB/c mice, but not in C3H/HeN mice. Our findings suggest that the production of GM-CSF is involved in the in vitro proliferation of SMNC in reaction to SEPS and that along with IL-1 and PGE2 production, contributes to the inflammation by SEPS in vivo.

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Section: Precise Mechanisms Of Pg Fractions Especiallysupporting

confidence: 86%

Induction of Acute Arthritis in Mice by Peptidoglycan Derived from Gram‐Positive Bacteria and Its Possible Role in Cytokine Production

Onta

Fujii

et al. 1993

Microbiology and Immunology

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“…Nagao et al (23,24) reported species dependency of in vitro macrophage activation by peptidoglycans and MDP; guinea pig and rat cells were responsive, but murine cells were not. In human peripheral blood mononuclear cell cultures, MDP is a powerful cytokine inducer comparable to LPS.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Muramyldipeptide with Lipopolysaccharide or Lipoteichoic Acid To Induce Inflammatory Cytokines in Human Monocytic Cells in Culture

et al. 2001

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“…Peptidoglycans showed no immunostimulatory activities in murine macrophage cultures [21], and those of M. luteus were reported to show only weak immunoadjuvant activity in guinea-pigs as compared with other bacterial peptidoglycans [19,20]. In the present study, no induction of anaphylactoid reactions was observed in MDP-primed and peptidoglycan-challenged C3H=HeN mice and little or no TNF-á or IL-6 was detected in the serum of the mice.…”

Section: Discussionmentioning

confidence: 46%

“…However, the immunoadjuvant activities of peptidoglycans of M. luteus in guinea-pigs were reported to be weak compared with those of other bacterial peptidoglycans [19,20]. It was also reported that bacterial peptidoglycans showed low cytokineinducing activities in murine macrophage culture [21]. The immunomodulating activities of teichuronic acids have not been studied.…”

Section: Introductionmentioning

confidence: 99%

Induction of necrosis factor-α and interleukin-6 in mice in vivo and in murine peritoneal macrophages and human whole blood cells in vitro by Micrococcus luteus teichuronic acids

Monodane¹,

Kawabata²,

Yang³

et al. 2001

Journal of Medical Microbiology

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Species dependency of macrophage activation by bacterial peptidoglycans

Cited by 6 publications

References 24 publications

Induction of Acute Arthritis in Mice by Peptidoglycan Derived from Gram‐Positive Bacteria and Its Possible Role in Cytokine Production

Induction of Acute Arthritis in Mice by Peptidoglycan Derived from Gram‐Positive Bacteria and Its Possible Role in Cytokine Production

Synergistic Effect of Muramyldipeptide with Lipopolysaccharide or Lipoteichoic Acid To Induce Inflammatory Cytokines in Human Monocytic Cells in Culture

Induction of necrosis factor-α and interleukin-6 in mice in vivo and in murine peritoneal macrophages and human whole blood cells in vitro by Micrococcus luteus teichuronic acids

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