Species Differences in the Effectiveness of Intestinal Barriers against Penetration of Inert Particulates and Bacteria

Cottier, H.; Schaffner, Th.; Chanana, A. D.; Joel, D. D.; Sordat, Bernard; Bryant, Becky; Hess, M. W.

doi:10.1007/978-3-7091-8396-0_12

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1980

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“…Under normal circumstances, penetration of the intestinal epithelium by microbial agents in the lumen is thought to occur at epithelial discontinuities overlying the dome regions of gutassociated lymphoid tissue or at the tips of the villi and by pinocytosis (5). Our data indicate that during endotoxemia and possibly in other pathological circumstances, disruption of tight junctional barriers of the intestinal epithelium may be an important route for escape of lumenal contents.…”

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confidence: 75%

Disruption of the permeability barrier (zonula occludens) between intestinal epithelial cells by lethal doses of endotoxin

Walker¹,

Porvaznik²

1978

Infect Immun

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Section: Downloaded Frommentioning

confidence: 75%

Disruption of the permeability barrier (zonula occludens) between intestinal epithelial cells by lethal doses of endotoxin

Walker¹,

Porvaznik²

1978

Infect Immun

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Intestinal barrier to large particulates in mice

LeFevre

Hancock

Joel

1980

Journal of Toxicology and Environmental Health

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Intestinal barrier function in mice was assessed after acute or chronic oral administration of 15.8- and 5.7-micron synthetic spherical particles. The results failed to confirm previous reports that ingested particles rapidly appear in blood. Furthermore, 15.8-micron particles did not accumulate in intestinal Peyer's patches, mesenteric lymph nodes, or other organs of the reticuloendothelial system, even after the maximum dosage of 8 X 10(6) particles per day for 60 d. However, the 5.7-micron particles were demonstrated in Peyer's patches, mesenteric lymph nodes, and lungs after the maximum dosage of 4.5 X 10(8) particles per day for 60 d. At 77 d after the termination of ingestion, 5.7-micron particles were still present in these tissues. The 5.7-micron particles were not found in spleen; retention in liver was equivocal. The site of uptake of particles capable of penetrating the intestinal mucosa appears to be the Peyer's patches. It is suggested that most absorbed particles are sequestered in Peyer's patch macrophages. Particles that escape sequestration are transported by lymph rather than by portal blood. The findings indicate that hazards associated with intestinal uptake of large (> 5 micron) particulates exist, but that the frequency of such penetration is still unclear.

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Species Differences in the Effectiveness of Intestinal Barriers against Penetration of Inert Particulates and Bacteria

Cited by 2 publications

References 30 publications

Disruption of the permeability barrier (zonula occludens) between intestinal epithelial cells by lethal doses of endotoxin

Disruption of the permeability barrier (zonula occludens) between intestinal epithelial cells by lethal doses of endotoxin

Intestinal barrier to large particulates in mice

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