Species Differences of Dopaminergic Vasodilation in the Intestine

Kullmann, R.; Wassermann, Karsten; Rissing, R.; Huß, R.

doi:10.1016/b978-0-08-023189-1.50067-3

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…Responses of the peripheral vasculature to dopamine have been shown to vary between different mammals. 24 Studies in dogs suggest that the vasodilator effect of dopamine within the superior mesenteric circulation can be overridden by concurrent stimulation of ␣ adrenoceptors at doses higher than 10 g kg 91 min 91 . 5 25 Yet, this vasoconstrictor effect in dogs is not representative of other mammals, such as pigs, cats and rabbits, where vasodilatation persists at i.v.…”

Section: Clinical Relevance and Limitations Of The Studymentioning

confidence: 99%

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Dopamine and intestinal mucosal tissue oxygenation in a porcine model of haemorrhage

Germann

Haisjackl

Schwarz

et al. 1997

British Journal of Anaesthesia

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Haemorrhage is associated with intestinal mucosal hypoxia and impaired gut barrier function. Dopamine increases oxygen delivery to the intestinal mucosa and may thus counteract haemorrhage-induced mucosal hypoxia. Jejunal mucosal tissue oxygen tension (mucosal PO2) and jejunal oxygen saturation of mucosal microvascular haemoglobin (mucosal HbO2) were measured in 14 anaesthetized pigs. Seven animals served as controls (group C) and seven received continuous infusion of dopamine 16 micrograms kg-1 min-1 (group D) while 45% of blood volume was removed in three equal increments. Resuscitation was performed using shed blood and fluid. Mean arterial pressure and systemic oxygen delivery decreasing significantly during haemorrhage and returned to baseline after resuscitation in both groups. Mucosal PO2 decreased from 4.4 to 1.7 kPa after haemorrhage (P < 0.01) and further to 1.5 kPa after resuscitation (P < 0.01) in group C whereas group D showed an increase from 3.9 to 5.9 kPa after the start of the dopamine infusion (P < 0.05), but no significant difference from baseline after haemorrhage (2.3 kPa) (ns) or resuscitation (3.1 kPa) (ns). Mucosal HbO2 decreased from 52 to 32% after haemorrhage (P < 0.05) and increased to near baseline (37%) (ns) after resuscitation in group C whereas group D showed no significant changes from baseline (54%) throughout the experiment. Comparison between groups showed higher mucosal PO2 and HbO2 values for group D animals after the start of the dopamine infusion (P < 0.05 each), after the first two steps of haemorrhage (P < 0.01 each) and after resuscitation (P < 0.05 each). We conclude that i.v. dopamine 16 micrograms kg-1 min-1 improved tissue oxygenation of the small intestinal mucosa during moderate haemorrhage and subsequent resuscitation.

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Section: Clinical Relevance and Limitations Of The Studymentioning

confidence: 99%

“…doses of 20, 26 25 6 and 50 g kg 91 min 91 . 24 In humans, the mesenteric vasoconstrictor threshold is still unknown. Clinical evaluation of whether or not dopamine is suitable to treat intestinal mucosal hypoxia could be facilitated by monitoring techniques measuring mucosal tissue oxygenation.…”

Section: Clinical Relevance and Limitations Of The Studymentioning

confidence: 99%

Dopamine and intestinal mucosal tissue oxygenation in a porcine model of haemorrhage

Germann

Haisjackl

Schwarz

et al. 1997

British Journal of Anaesthesia

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“…Activation of other dopamine receptors leads to a modified sympathetic noradrenergic transmission through presynaptic inhibition (16)(17)(18)(19)(20). Reports are, however, contradictory on the extent to which this mechanism is responsible for the circulatory effects seen after dopamine administration (22). Studies using dopamine agonists and antagonists have shown pharmacological differences between these two anatomically distinct dopamine receptors (23,24).…”

Section: Discussionmentioning

confidence: 99%

Does Dopamine Suppress Stress‐Induced Intestinal and Renal Vasoconstriction?

Winsö

Biber

Martner

1985

Acta Anaesthesiol Scand

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Dopamine interference with intestinal and renal sympathetic reflex vasoconstrictor responses was studied in cats anaesthetized with diazepam, fentanyl and nitrous oxide. Vasoconstriction was induced by electric stimulation of the hypothalamic defence-alarm area and by stimulation of somatic and visceral afferents. In addition, intestinal vasoconstriction was elicited by direct stimulation of postganglionic sympathetic efferent nerves. In the intestine, dopamine administration (7.5 microgram X kg-1 X min-1) was not associated with an attenuation of the investigated sympathetic vasoconstrictor responses, although dopamine per se decreased intestinal vascular resistance by 36 +/- 4%. Due to this dopamine-induced background vasodilation, the intestinal blood flow level during stimulation procedures and concomitant dopamine infusion was higher than during similar stimulations prior to dopamine (for defence-alarm area stimulation 45 +/- 16%, for afferent nerve stimulation 79 +/- 22% and for efferent postganglionic nerve stimulation 66 +/- 16%). In the kidney, dopamine per se had only minor effects on vascular resistance and on changes in vascular tone elicited by the stimulation procedures. The renal blood flow level in response to the stimulation procedures was not significantly affected by dopamine. In conclusion, dopamine may contribute to a sustained intestinal blood flow level when administered during supervening stress-related sympathetic activation.

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“…Hinkley (1976) has reported the production of macrotubular structures by halothane in crayfish axons, but none of this type of organelle was found in the unmyelinated axons from the rat. Dopamine produces hypotension and dilates certain vascular beds in dogs, cats, rabbits and man, an action that is suggested to be mediated by stimulation of specific receptor sites (Goldberg, 1972) In rabbits, dopamine increases blood flow in the coeliac artery and produces hypotension which is inhibited by bulbocapnine (Kullman, Rissing & Wasserman, 1978;Tseng & Walaszek, 1970) We have studied the vascular relaxation effect of dopamine in vitro, using the splenic branch of the coeliac artery of the rabbit. Spirally cut strips of the splenic artery were suspended under 1.5 g isometric tension, in organ baths containing Krebs solution maintained at 37°C, bubbled with 95% 02/5% C02, and to which had been added indomethacin (2 tg/ml).…”

Section: Effect Of Halothane On Microtubule Numbers Inmentioning

confidence: 99%

Proceedings of the British Pharmacological Society

1979

British J Pharmacology

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Species Differences of Dopaminergic Vasodilation in the Intestine

Cited by 8 publications

References 23 publications

Dopamine and intestinal mucosal tissue oxygenation in a porcine model of haemorrhage

Dopamine and intestinal mucosal tissue oxygenation in a porcine model of haemorrhage

Does Dopamine Suppress Stress‐Induced Intestinal and Renal Vasoconstriction?

Proceedings of the British Pharmacological Society

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