Species distribution and in vitro antifungal susceptibility patterns of Candida

Mondal, S; Mondal, A; Pal, N; Banerjee, P; Kumar, S; Bhargava, D

doi:10.3126/joim.v35i1.8897

Cited by 13 publications

(18 citation statements)

References 12 publications

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“…Our finding shows similar prevalence scenario of Candida species and susceptibility pattern to the previous data reported by two independent groups from India which showed C. albicans is more prevalent among the Candida isolates [16, 17]. Similar study conducted by Sajjan et al also reported C. albicans as the major isolate.…”

Section: Discussionsupporting

confidence: 91%

Isolation, speciation and antifungal susceptibility testing of Candida isolates from various clinical specimens at a tertiary care hospital, Nepal

et al. 2017

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Background Candida species are responsible for various clinical infections ranging from mucocutaneous infection to life threatening invasive diseases along with increased resistance to antifungal drugs has made a serious concern. Resistance to antifungal agents has increased during the last decade. Thus, identification of Candida up to species level and its antifungal susceptibility testing has a paramount significance in the management of Candidal infections. The aim of the study was to speciate Candida species and to determine antifungal susceptibility pattern of Candida species to antifungal agents.MethodsA total of 100 consecutive Candida species were isolated from 1248 clinical specimens over 7 months period. Growths on Sabouraud dextrose agar were evaluated for colony appearance, macroscopic examination, Gram staining, germ tube test and urea hydrolysis test. Further, they were processed for Candida speciation on CHROMagar. Antifungal susceptibility testing was performed as recommended by Clinical and Laboratory Standards Institute (CLSI) M44-A document.ResultsOut of 100 Candida isolates, Candida albicans (56%) was the most common species. Among the non-albicans Candida species, Candida tropicalis (20%) was the predominant isolate followed by Candida glabrata (14%). Regarding antifungal susceptibility pattern, Candida species were more susceptible to clotrimazole (82%) followed by fluconazole (64%) and miconazole (44%).Conclusions Candida albicans was the predominant species responsible for various Candidal infections. Among commonly used antifungal drugs clotrimazole, miconazole and fluconazole were most effective.

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Section: Discussionsupporting

confidence: 91%

Isolation, speciation and antifungal susceptibility testing of Candida isolates from various clinical specimens at a tertiary care hospital, Nepal

et al. 2017

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“…4 Drug resistance to azoles is emerging, hence early speciation and antifungal susceptibility pattern helps in guiding the physician in choosing the appropriate antifungal drug and thus prevent therapeutic failures. 5 The aim of the present study was to determine the prevalence and antifungal susceptibility of various Candida species in our tertiary care hospital.…”

Section: Introductionmentioning

confidence: 99%

Rapid identification and susceptibility pattern of various Candida isolates from different clinical specimens in a tertiary care hospital in Western Uttar Pradesh

et al. 2017

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Background: Candida species are component of normal flora of human beings. Candidiasis is the commonest fungal disease affecting mucosa, skin, nails and internal organs. A variety of predisposing factors are known to cause candidiasis either by altering balance of normal microbial flora of the body or by lowering the host defence.Methods: A total of 90 specimens submitted in the department of microbiology were included in this study. Identification of Candida species as well as antifungal sensitivity testing was performed with Vitek®2 compact (Biomerieux France) using Vitek2 cards for identification of yeast and yeast like organisms (ID-YST cards). Antifungal susceptibility testing was performed using Vitek2 fungal susceptibility card (AST YS01) kits respectively.Results: The distribution of the clinical samples were urine 53 (58.9%), sputum 14 (15.5%), blood 10 (11.1%), nail 6 (6.7%) and high vaginal swab 7 (7.8%). Among 90 clinical isolates, species obtained were C. tropicalis 53 (59%), C. albicans 23 (25.5%), C. glabrata 6 (6.7%), C. parapsilosis 4 (4.4%), C. krusei 2 (2.2%), C. pelliculosa 1 (1.1%), C. famata 1 (1.1%).Conclusions: Infections caused by non-candida albicans species have increased. Identification of Candida species and their antifungal susceptibility are important for the treatment of hospitalized patients with serious underlying disease.

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“…da mucosa oral de pacientes HIV-posi vo da Turquia e detectaram que 92% de linhagens de C.albicans foram susce veis ao cetoconazol, diferente das amostras de CNA em que 72,2% foram classifi cados como sensíveis. Mondal et al (2013) observaram que a maioria (81,5%) das linhagens de C. albicans foram sensíveis ao cetoconazol, sendo que, para este mesmo an fúngico, a susce bilidade para CNA foi de 68%. Camila Aoyama VIEIRA; Wérika Weryanne Rosa de SOUZA; Janaína Sousa de LIMA; Le cia Silveira GOULART Os genes SAP são reconhecidos por desempenharem um papel importante na patogenicidade de C. albicans; estes são agrupados em 6 subgrupos, SAP1-SAP3, SAP4-SAP6, SAP7, SAP8, SAP9 e SAP10 cada um caracterizado por uma estreita homologia e relevância fi siológica.…”

Section: Resultsunclassified

Estudo comparativo das espécies de <em>Candida</em>: sensibilidade antifúngica e genes de virulência

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Souza

Lima

et al. 2018

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O objetivo deste estudo foi comparar a sensibilidade antifúngica e a presença dos genes de virulência SAP1-3 em linhagens de Candida spp. Foram estudados 49 isolados, sendo 30 C. albicans e 19 Candida não-albicans (CNA). A determinação do perfil de sensibilidade foi realizada conforme protocolo do Clinical and Laboratory Standards Institute. Para identificação dos genes SAP1-3, foi utilizado método de PCR. Todas as amostras de C. albicans foram sensíveis ao fluconazol, dentre as CNA 21% foram sensíveis e 68,4% foram SDD, 100% das linhagens de C. albicans e 94,7% de CNA foram sensíveis ao cetoconazol. Para itraconazol, 86,7% dos isolados de C. albicans e 42,1% de CNA foram sensíveis. Os genes mais frequentes nas linhagens de C. albicans foram SAP1 (56,6%,) e SAP2 (40%) seguido de SAP3 (26%). As amostras de CNA apresentaram um predomínio de SAP2 (42,1%), seguido por SAP1 (10,5%), SAP3 não foi identificado. As espécies de Candida apresentam diferenças significativas quanto ao perfil de sensibilidade a azólico e em relação à presença dos genes SAP1-3, sugerindo que esses fatores devem refletir em uma terapêutica e patogênese distintas para estas leveduras.

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Species distribution and in vitro antifungal susceptibility patterns of Candida

Cited by 13 publications

References 12 publications

Isolation, speciation and antifungal susceptibility testing of Candida isolates from various clinical specimens at a tertiary care hospital, Nepal

Isolation, speciation and antifungal susceptibility testing of Candida isolates from various clinical specimens at a tertiary care hospital, Nepal

Rapid identification and susceptibility pattern of various Candida isolates from different clinical specimens in a tertiary care hospital in Western Uttar Pradesh

Estudo comparativo das espécies de <em>Candida</em>: sensibilidade antifúngica e genes de virulência

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