2019
DOI: 10.1128/jb.00576-18
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Species Widely Distributed in Halophilic Archaea Exhibit Opsin-Mediated Inhibition of Bacterioruberin Biosynthesis

Abstract: Halophilic Archaea are a distinctive pink color due to a carotenoid pigment called bacterioruberin. To sense or utilize light, many halophilic Archaea also produce rhodopsins, complexes of opsin proteins with a retinal prosthetic group. Both bacterioruberin and retinal are synthesized from isoprenoid precursors, with lycopene as the last shared intermediate. We previously described a regulatory mechanism by which Halobacterium salinarum bacterioopsin and Haloarcula vallismortis cruxopsin inhibit bacterioruberi… Show more

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Cited by 5 publications
(4 citation statements)
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References 46 publications
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“…3 ), a 7-transmembrane protein that function as a light-driven ion transporter. However, YIM 93972 lacks the genes encoding enzymes involved in the biosynthesis of bacterioruberin (in particular, lycopene elongase, halo.01227), a C 50 carotenoid that has been identified in several extremely halophilic archaea, the production of which is regulated by halorhodopsin 13 , 14 .…”
Section: Resultsmentioning
confidence: 99%
“…3 ), a 7-transmembrane protein that function as a light-driven ion transporter. However, YIM 93972 lacks the genes encoding enzymes involved in the biosynthesis of bacterioruberin (in particular, lycopene elongase, halo.01227), a C 50 carotenoid that has been identified in several extremely halophilic archaea, the production of which is regulated by halorhodopsin 13 , 14 .…”
Section: Resultsmentioning
confidence: 99%
“…(Giani et al, 2019). The carotenoid biosynthesis pathway and its regulation has been studied in detail at the transcriptional level in photosynthetic organisms (Toledo-Ortiz et al, 2010;Stanley and Yuan, 2019) and to a very limited extent in archaea (Tarasov et al, 2008;Peck et al, 2017Peck et al, , 2019. In the last years post-translational control of PSY by proteolysis emerged as a novel strategy to modulate carotenogenesis in plants (Welsch et al, 2018;Wang et al, 2020).…”
Section: Cellular Processes Regulated By Membrane Proteases In Halofe...mentioning
confidence: 99%
“…Although complete metabolism and the origin of metabolic routes in haloarchaea are still unknown, it is clear that they have acquired genes from bacterial pathways such as mevalonate through horizontal gene transfer [15]. The origin and understanding of this pathway have not been fully decrypted due to the erratic genetic pattern that codes for the enzymes of this route [16]; the carotenoid pigments in these organisms are synthetized by this pathway, which starts with acetyl-CoA, and starting from this point, it should be verify which compounds could stimulate pigmentation.…”
Section: Introductionmentioning
confidence: 99%