Specific antibody patterns over a two-year period after rubella immunization with RA 27/3 live attenuated vaccine

Immune responses to wild and vaccine rubella viruses after rubella vaccination

“…All the vaccinees showed a vaccine-induced seroconversion evaluated by HAI and NT antibodies as soon as one month after vaccination. Even if specific antibody titres elicited by vaccination were considerably lower than those induced by natural infection [17,18] they persist up to three years after immunization [23]. Failure to demonstrate IgM in some sera one month after vaccination is probably due to the limited sensitivity of the kit used.…”

Possibility of reinfection after immunisation with RA 27/3 live attenuated rubella virus

“…E 1, E2, C Wild rubella virus structural proteins + Presence, -absence of antibodies R A 27/3 strain has been reported to be a better i m m u n o g e n than other rubella attenuated virus strains [4,5], however, the antibody titres elicited after inamunisation were considerably lower than those induced by natural infection [1,6]. In the 10 examined subjects, the antibody G M T had been decreasing during the following four years after immunisation, suggesting that the vaccineinduced h u m o r a l i m m u n i t y might sometimes wane rapidly.…”

Rötelsituation in Deutschland

“…Werden die mittleren IU/ml für Rötelnantikörper in den Altersgruppen der 1-bis 20-Jährigen in den drei erstgenannten Stichproben betrachtet, so sind die höchsten Werte bei den 3-bis <6-Jährigen in der Studie von 1990/DDR zu finden (320 IU/ml, Konfidenzintervall KI 234-405) sowie bei den 6-bis 15 …”