Specific antigen‐guiding exosomes inhibit food allergies by inducing regulatory T cells

Yu, Dian; Liu, Jiang‐Qi; Mo, Li‐Hua; Luo, Xiang‐Qian; Liu, Zhiqiang; Wu, Guangyao; Yang, Liteng; Liu, Dabo; Wang, Shuai; Yang, Ping‐Chang

doi:10.1111/imcb.12347

Cited by 12 publications

(15 citation statements)

References 29 publications

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“…The association between Tert expression in intestinal DCs and the FA response was tested. A FA murine model was established with reported procedures [15] (Fig. 2A).…”

Section: Resultsmentioning

confidence: 99%

Regulation of Tert methylation alleviates food allergy via regulating the Tert-IL10 signal pathway

Zeng,

Xu,

Liu

et al. 2024

Preprint

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The pathogenesis of food allergy (FA) is still not fully understood. Telomerases are involved in the regulation of immune responses. The aim of this study is to understand the contribution of telomerase reverse transcriptase (TERT) to the pathogenesis of FA. A murine FA model was established with ovalbumin as the specific antigen. This murine model was used to test the role of TERT in the regulation of dendritic cell (DC) immune tolerogenic functions. We observed that the Tert promoter was at demethylation status and the Tert expression was elevated in DCs of FA mice. The FA response was positively correlated with the Tert expression in DCs. Induction of Il10 expression in DCs was hindered by TERT. TERT hindered the immune tolerogenic functions of DCs. The immune tolerogenic functions of DC were restored by CpG by boosting the Tert promoter methylation. Administration of CpG promoted the therapeutic effects of allergen specific immunotherapy in FA mice. In conclusion, low levels of Il10 expression and high levels of Tert expression were observed in intestinal DCs of FA mice. CpG exposure restored the expression of Il10 and increased the therapeutic benefits of allergen-specific immunotherapy.

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“…The association between Tert expression in intestinal DCs and the FA response was tested. A FA murine model was established with reported procedures [15] (Fig. 2A).…”

Section: Resultsmentioning

confidence: 99%

Regulation of Tert methylation alleviates food allergy via regulating the Tert-IL10 signal pathway

Zeng,

Xu,

Liu

et al. 2024

Preprint

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“…In a different study, it was shown that MSC-derived exosomes alleviate atopic dermatitis [97]. Interestingly, regulatory DCs stimulated with IL-2 and antigen produce exosomes carrying IL-2 and p-MHCII complexes which promote Tregs and suppress allergic inflammation in a murine model of food allergy [98]. This concept fits into the strategy of expanding T regs via IL-2, which has been a promising and fast-evolving field, including in allergy immunotherapy [99,100].…”

Section: "Tolerosomes" For the Suppression Of Allergic Th2 Responsesmentioning

confidence: 98%

“…A main goal in allergy immunotherapy is the induction of regulatory T cells. Exosomes derived from IL-2 primed tolerogenic DCs were shown to promote regulatory T cells[98]. Additionally, MSC derived exosomes promote regulatory T cells[96].…”

mentioning

confidence: 99%

The Potential of Exosomes in Allergy Immunotherapy

Engeroff

Vogel

2022

Vaccines

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Allergic diseases represent a global health and economic burden of increasing significance. The lack of disease-modifying therapies besides specific allergen immunotherapy (AIT) which is not available for all types of allergies, necessitates the study of novel therapeutic approaches. Exosomes are small endosome-derived vesicles delivering cargo between cells and thus allowing inter-cellular communication. Since immune cells make use of exosomes to boost, deviate, or suppress immune responses, exosomes are intriguing candidates for immunotherapy. Here, we review the role of exosomes in allergic sensitization and inflammation, and we discuss the mechanisms by which exosomes could potentially be used in immunotherapeutic approaches for the treatment of allergic diseases. We propose the following approaches: a) Mast cell-derived exosomes expressing IgE receptor FcεRI could absorb IgE and down-regulate systemic IgE levels. b) Tolerogenic exosomes could suppress allergic immune responses via induction of regulatory T cells. c) Exosomes could promote TH1-like responses towards an allergen. d) Exosomes could modulate IgE-facilitated antigen presentation.

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“…In a different study it was shown that MSC-derived exosomes alleviate atopic dermatitis [83]. Interestingly, regulatory DCs stimulated with IL-2 and antigen produce exosomes carrying IL-2 and p-MHCII complexes which promote Tregs and suppress allergic inflammation in a murine model of food allergy [84]. This concept fits into the strategy of expanding of T regs via IL-2, which has been a promising and fast-evolving field, including in allergy immunotherapy [85], [86].…”

Section: "Tolerosomes" For the Suppression Of Allergic Th2 Responsesmentioning

confidence: 99%

The Potential of Exosomes in Allergy Immunotherapy

Engeroff¹,

Vogel²

2021

Preprint

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Allergic diseases represent a global health and economic burden of increasing significance. The lack of disease-modifying therapies besides specific allergen immunotherapy (AIT) which is not available for all types of allergies, necessitates the study of novel therapeutic approaches. Exosomes are small endosome-derived vesicles delivering cargo between cells and thus allowing inter-cellular communication. Since immune cells make use of exosomes to boost, deviate, or suppress immune responses, exosomes are intriguing candidates for immunotherapy. Here, we review the role of exosomes in allergic sensitization and inflammation and we discuss the mechanisms by which exosomes could be used in immunotherapeutic approaches for the treatment of allergic diseases. We propose the following approaches: a) Mast cell derived exosomes expressing IgE receptor FcεRI could absorb IgE and down-regulate systemic IgE levels. b) Tolerogenic exosomes could suppress allergic immune responses via induction of regulatory T cells. c) Exosomes could promote TH1-like responses towards an allergen. d) Exosomes could modulate IgE-facilitated antigen presentation.

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Specific antigen‐guiding exosomes inhibit food allergies by inducing regulatory T cells

Cited by 12 publications

References 29 publications

Regulation of Tert methylation alleviates food allergy via regulating the Tert-IL10 signal pathway

Regulation of Tert methylation alleviates food allergy via regulating the Tert-IL10 signal pathway

The Potential of Exosomes in Allergy Immunotherapy

The Potential of Exosomes in Allergy Immunotherapy

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