Specific changes in food intake elicited by blockade or activation of glutamate receptors in the nucleus accumbens shell

Stratford, Thomas R.; Swanson, Chad J.; Kelley, Ann E.

doi:10.1016/s0166-4328(97)00140-x

Cited by 119 publications

(97 citation statements)

References 34 publications

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“…However, we suggest that this explanation is unlikely because using identical procedures we have shown robust effects of amphetamine infusions into the shell to increase responding with conditioned reinforcement , while similarly large effects were also seen by Wyvell and Berridge (2000), again using vertical cannulae. Most importantly, a number of studies have demonstrated behavioral effects of intra-shell infusion of GABA-ergic (Stratford and Kelley 1997) and glutamatergic (Stratford et al 1998) drugs through vertical cannulae at stereotaxic coordinates similar to those used in the present study. It should be noted that in the present study the 5 nmol dose of AP-5 decreased response rates during the second interval only, indicating that the drug was effective when infused into the shell.…”

Section: The Effects Of Nmda Receptor Antagonism In the Core And Shellmentioning

confidence: 70%

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

Ciano

Everitt

2001

Neuropsychopharmacology

258

191

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Section: The Effects Of Nmda Receptor Antagonism In the Core And Shellmentioning

confidence: 70%

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

Ciano

Everitt

2001

Neuropsychopharmacology

258

191

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“…A large series of studies demonstrated a role for glutamate in meal size using localized microinfusions in brain areas associated with feeding or reinforcement (e.g., Zeni et al 2000). Infusions of glutamate in the Nucleus Accumbens decreased food intake, while infusions of glutamate antagonists in the Nucleus Accumbens increased food intake by increasing meal size rodents (Maldonado-Irizarry et al 1995;Stratford et al 1998;Zeni et al 2000), and central infusions of glutamate agonists and antagonists in the pigeon produced a similar pattern of results (Da Silva et al 2006;Gillespie et al 2005). Several studies have also shown that peripheral administration of the NMDA non-competitive antagonist (+)MK-801 (dizocilpine) also increased meal size in the rat (Treece et al 2000;Jahng and Houpt 2001), perhaps due to an increase in the rate of gastric emptying (Covasa et al 2000).…”

Section: Discussionmentioning

confidence: 99%

A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine

2008

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Rationale-Procedures for studying the effects of medications on satiation will assist the development of obesity medications.Objectives-Develop a procedure for measuring satiation during consumption of bland and highly palatable food, and determine the effect of acute intramuscular administration of dexfenfluramine (DFEN), which increases serotonin levels, and memantine (MEM), which blocks N-methyl-Daspartate receptors.Methods-A modified progressive ratio (PR) procedure was used to track changes in reinforcing strength when a food was consumed. The response requirement increased after each reinforcement, and reinforcing strength was estimated using the breakpoint (BP), which was the last completed response cost. There was one preferred food (sweet candy) and one chow pellet PR session per week. During each session, 4 male and 4 female adult baboons experienced three 1-hr PR trials, separated by 30 min. Chow pellets were available at all other times. We examined the BP for 1 to 20 candies or chow pellets. Drug effects were examined when baboons had access to 1 and 10 candies/pellets.Results-Breakpoints for candy were greater than for pellets. Varying the pellet/candy pieces per delivery, produced an inverted U-shaped function on the first trial, i.e., maximal BP was observed for 3 items, and the BP for multiple items, but not a single item, decreased across trials, i.e., BP decreased with food intake and satiation. DFEN and MEM decreased responding with the greatest effects at 10 deliveries suggesting that DFEN and MEM enhanced satiation.Conclusion-Drugs that enhance satiation for several types of food may be particularly effective for decreasing food intake.

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“…Ionotropic glutamate receptors (iGluR) include N-methyl-D-aspartic acid (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainite receptors and metabotropic (mGluR) glutamate receptors (mGluR I, mGluR II, mGluR III) [49] . It is well documented that ICV injection of glutamate or its agonists into the lateral hypothalamus diminished food intake in mammals [50][51][52] . In comparison, ICV injection of glutamate reduces feed intake and increases latency time to start feeding in cockerels.…”

Section: Glutamatementioning

confidence: 99%

Central regulation of food intake in mammals and birds: a review

Zendehdel

Hassanpour

2015

Neurotransmitter

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Appetite regulates by a complex system of central and peripheral signals which interact in order to modulate ingestion response. A number of peptides comprise a complex network that regulates feeding behavior in vertebrates. This review is focused on the main neurotransmitters and peptides that influence feeding responses in mammals and birds. On the basis of literature review, there are several evidences that neurotransmitters have different effects on food intake between mammals and birds. Also, central regulation of food intake regulates via different mechanisms in animals. So, the aim of this review was to investigate comparative food-intake regulation mechanisms in mammals and birds.

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Specific changes in food intake elicited by blockade or activation of glutamate receptors in the nucleus accumbens shell

Cited by 119 publications

References 34 publications

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine

Central regulation of food intake in mammals and birds: a review

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