Specific immune response to mRNA vaccines against COVID-19 in patients receiving allogeneic stem cell transplantation for myeloid malignancy was altered by immunosuppressive therapy

Mackova, Jana; Hainz, Petr; Kryštofová, Jitka; Roubalová, K; Šťastná-Marková, Markéta; Vaníková, Šárka; Musil, Jan; Vydra, Jan; Němečková, Šárka

doi:10.1016/j.leukres.2023.107314

Cited by 1 publication

(2 citation statements)

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“…In particular, an impairment of both humoral and cellular response has been shown in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients taking corticosteroids during or prior the vaccination administration [ 78 ]. Vaccine-induced T-cell response is also influenced by the time between vaccine administration and transplant, with effector memory CD4 T-cells being detectable after CD4 reconstitution [ 78 ]. T-cell response was also increased through completion of the vaccine schedule in allo-HSCT patients.…”

Section: Current Views On Sars-cov-2-specific T-cell Responsesmentioning

confidence: 99%

“…Moreover, like patients with HSCT, booster vaccination doses have been suggested for patients with hematologic malignancies [ 80 ]. In contrast to CD20 inhibitors, anticancer therapies with checkpoint inhibitors seem to be associated with an impaired T-cell response, mainly in the CD4 compartment [ 78 ].…”

Section: Current Views On Sars-cov-2-specific T-cell Responsesmentioning

confidence: 99%

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The Importance of Measuring SARS-CoV-2-Specific T-Cell Responses in an Ongoing Pandemic

et al. 2023

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Neutralizing antibodies are considered a correlate of protection against SARS-CoV-2 infection and severe COVID-19, although they are not the only contributing factor to immunity: T-cell responses are considered important in protecting against severe COVID-19 and contributing to the success of vaccination effort. T-cell responses after vaccination largely mirror those of natural infection in magnitude and functional capacity, but not in breadth, as T-cells induced by vaccination exclusively target the surface spike glycoprotein. T-cell responses offer a long-lived line of defense and, unlike humoral responses, largely retain reactivity against the SARS-CoV-2 variants. Given the increasingly recognized role of T-cell responses in protection against severe COVID-19, the circulation of SARS-CoV-2 variants, and the potential implementation of novel vaccines, it becomes imperative to continuously monitor T-cell responses. In addition to “classical” T-cell assays requiring the isolation of peripheral blood mononuclear cells, simple whole-blood-based interferon-γ release assays have a potential role in routine T-cell response monitoring. These assays could be particularly useful for immunocompromised people and other clinically vulnerable populations, where interactions between cellular and humoral immunity are complex. As we continue to live alongside COVID-19, the importance of considering immunity as a whole, incorporating both humoral and cellular responses, is crucial.

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Section: Current Views On Sars-cov-2-specific T-cell Responsesmentioning

confidence: 99%

Section: Current Views On Sars-cov-2-specific T-cell Responsesmentioning

confidence: 99%