Specific lipids of mycobacteria and related organisms

Batrakov, S. G.

doi:10.1007/bf00714900

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Cited by 2 publications

(1 citation statement)

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“…The glycerol is esterified at one of the primary alcohol groups [11]. The antigen isolated from Mycobacterium bovis BCG was shown to exist as two stereoisomers at the glycerol by comparison of the NMR spectrum with those of R-and S-glycerol isomers of GroMM prepared from mycolic acid mixtures isolated from M.tuberculosis H37Rv cells [12].…”

Section: Introductionmentioning

confidence: 99%

Glycerol mycolates from synthetic mycolic acids

Ali

Sahb

Dulayymi

et al. 2017

Carbohydrate Research

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Section: Introductionmentioning

confidence: 99%

Glycerol mycolates from synthetic mycolic acids

Ali

Sahb

Dulayymi

et al. 2017

Carbohydrate Research

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Mycolic Acids Constitute a Scaffold for Mycobacterial Lipid Antigens Stimulating CD1-Restricted T Cells

Layre

Collmann

Bastian

et al. 2009

Chemistry & Biology

136

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CD1-restricted lipid-specific T lymphocytes are primed during infection with Mycobacterium tuberculosis, the causative agent of tuberculosis. Here we describe the antigenicity of glycerol monomycolate (GroMM), which stimulates CD1b-restricted CD4(+) T cell clones. Chemical characterization of this antigen showed that it exists as two stereoisomers, one synthetic isomer being more stimulatory than the other. The hydroxyl groups of glycerol and the mycolic acid length are critical for triggering the T cell responses. GroMM was presented by M. tuberculosis-infected dendritic cells, demonstrating that the antigen is available for presentation during natural infection. Ex vivo experiments showed that GroMM stimulated T cells from vaccinated or latently infected healthy donors but not cells from patients with active tuberculosis, suggesting that GroMM-specific T cells are primed during infection and their detection correlates with lack of clinical active disease.

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Specific lipids of mycobacteria and related organisms

Cited by 2 publications

References 153 publications

Glycerol mycolates from synthetic mycolic acids

Glycerol mycolates from synthetic mycolic acids

Mycolic Acids Constitute a Scaffold for Mycobacterial Lipid Antigens Stimulating CD1-Restricted T Cells

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