Specific motion processing pathway deficit during eye tracking in schizophrenia: A performance-matched functional magnetic resonance imaging study

Hong, L. Elliot; Tagamets, Malle A.; Avila, Matthew T.; Wonodi, Ikwunga; Holcomb, Henry H.; Thaker, Gunvant K.

doi:10.1016/j.biopsych.2004.12.015

Cited by 72 publications

(59 citation statements)

References 35 publications

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“…However, it has been reported that smooth pursuit quality (measured by pursuit gain or catch-up saccade rate) is significantly associated with measures of frontal structural integrity (Bagary et al, 2004) and frontal activation in schizophrenic patients (Ross et al, 1995;Hong et al, 2005;Keedy et al, 2006) and unaffected relatives (O'Driscoll et al, 1999). Although the PhysAn group did tend towards poorer pursuit gain, the small number of subjects made these results insignificant here.…”

Section: Discussionmentioning

confidence: 59%

Stress-Induced Dopamine Release in Humans at Risk of Psychosis: a [11C]Raclopride PET Study

Soliman

O’Driscoll

Pruessner

et al. 2007

Neuropsychopharmacol

133

109

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Drugs that increase dopamine levels in the brain can cause psychotic symptoms in healthy individuals and worsen them in schizophrenic patients. Psychological stress also increases dopamine release and is thought to play a role in susceptibility to psychotic illness. We hypothesized that healthy individuals at elevated risk of developing psychosis would show greater striatal dopamine release than controls in response to stress. Using positron emission tomography and [ 11 C]raclopride, we measured changes in synaptic dopamine concentrations in 10 controls and 16 psychometric schizotypes; 9 with perceptual aberrations (PerAb, ie positive schizotypy) and 7 with physical anhedonia (PhysAn, ie negative schizotypy). [ 11 C]Raclopride binding potential was measured during a psychological stress task and a sensory-motor control. All three groups showed significant increases in self-reported stress and cortisol levels between the stress and control conditions. However, only the PhysAn group showed significant stress-induced dopamine release. Dopamine release in the entire sample was significantly negatively correlated with smooth pursuit gain, an endophenotype linked to frontal lobe function. Our findings suggest the presence of abnormalities in the dopamine response to stress in negative symptom schizotypy, and provide indirect evidence of a link to frontal function.

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Section: Discussionmentioning

confidence: 59%

Stress-Induced Dopamine Release in Humans at Risk of Psychosis: a [11C]Raclopride PET Study

Soliman

O’Driscoll

Pruessner

et al. 2007

Neuropsychopharmacol

133

109

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“…The observed predictive acceleration deficit in schizophrenia may reflect a deficit in the strength of the FEF discharges. In support of this view, several imaging studies have shown reduced FEF activation in schizophrenia patients or their relatives during SPEM (23)(24)(25). In addition, transcranial magnetic stimulation of FEFs at the time of change in pursuit direction results in acceleration of the eye in the expected target direction (26), suggesting that poor predictive acceleration may be subjected to behavioral improvement using interventions to enhance FEF function.…”

Section: Discussionmentioning

confidence: 79%

Refining the Predictive Pursuit Endophenotype in Schizophrenia

Hong¹,

Turano

O’Neill³

et al. 2008

Biological Psychiatry

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Background-To fully utilize a schizophrenia endophenotype in gene search and subsequent neurobiological studies, it's critical that the precise underlying physiological deficit is identified. Abnormality in smooth pursuit eye movements is one of the endophenotypes of schizophrenia. The precise nature of the abnormality is unknown. Previous work has shown a reduced predictive pursuit response to a briefly masked (i.e. invisible) moving object in schizophrenia. However, the overt awareness of target removal can confound the measurement.

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“…The extraretinal motion-processing deficit is thought to be directly related to the eye-tracking abnormality in schizophrenia. 30,31 Our method of measuring the SPEM function is a global measurement of the SPEM, which is adequate for genetic analysis. We were thus able to quantitatively calculate the degree of SPEM impairment based on the Ln S/N ratio of the SPEM curves.…”

Section: Discussionmentioning

confidence: 99%

Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality

et al. 2009

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Schizophrenia is a multifactorial disorder characterized by the contribution of multiple susceptibility genes that may act in conjunction with epigenetic processes and environmental factors. The catechol-O-methyltransferase (COMT) gene, which is located in the 22q11 microdeletion, has been considered as a candidate gene for schizophrenia because of its ability to degrade catecholamines, including dopamine. In a genetic analysis, neurophysiological endophenotype in schizophrenia, such as smooth pursuit eye movement (SPEM) disturbance, is considered to be a good trait marker, because it may be under more direct genetic control. This study was performed to examine the genetic association of COMT polymorphisms with the risk of schizophrenia and SPEM abnormality in a Korean population. Six single-nucleotide polymorphisms of COMT were genotyped by TaqMan assay. Their genetic effects on the risk of schizophrenia were analyzed in 354 patients and 396 controls using v 2 analyses. Among the schizophrenic patients, 166 subjects were selected for association analyses of COMT polymorphisms with SPEM abnormality. From the six COMT polymorphisms, rs6267 showed an association with the reduced risk of schizophrenia after correction (P corr ¼ 0.02). In analysis of SPEM abnormality, no significant associations were detected with COMT polymorphisms. The results of the present study provide the evidence that in a Korean population, COMT on the 22q11 locus is likely involved in the development of schizophrenia, but not in the SPEM function abnormality.

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Specific motion processing pathway deficit during eye tracking in schizophrenia: A performance-matched functional magnetic resonance imaging study

Cited by 72 publications

References 35 publications

Stress-Induced Dopamine Release in Humans at Risk of Psychosis: a [11C]Raclopride PET Study

Stress-Induced Dopamine Release in Humans at Risk of Psychosis: a [11C]Raclopride PET Study

Refining the Predictive Pursuit Endophenotype in Schizophrenia

Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality

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