Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice

Verdú, Elena F.; Berčík, Přemysl; Verma-Gandhu, Monica; Huang, Xianxi; Blennerhassett, Patricia; Jackson, Wendy; Mao, Yu; Wang, Lu; Rochat, Florence; Collins, Stephen M.

doi:10.1136/gut.2005.066100

Cited by 399 publications

(336 citation statements)

References 36 publications

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“…A study in rats demonstrated that Lactobacillus reuteri can inhibit visceral pain through effects on enteric nerves. 58 Moreover, Verdu et al 59,60 have shown in two murine models that Lactobacillus paracasei normalizes visceral hypersensitivity and postinfective muscle hypercontractility. Lactobacillus reuteri is, nonetheless, the only strain in these mechanistic studies that has been investigated in a clinical trial, as well and in this case without success.…”

Section: Discussionmentioning

confidence: 99%

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome

Kajander

Krogius-Kurikka

Rinttilä

et al. 2007

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome

Kajander

Krogius-Kurikka

Rinttilä

et al. 2007

Aliment Pharmacol Ther

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“…Changes in the composition of GI commensals have been demonstrated in patients with IBS [Kassinen et al 2007;Malinen et al 2005]. Murine studies have demonstrated a reduction in visceral hypersensitivity [Verdu et al 2006], and attenuation of postinfectious muscle hypercontractility [Verdu et al 2004], following administration of probiotics. They may also have an influence on the host immune response to infection, as indicated by a reduction in circulating cytokine levels [O'Mahony et al 2005].…”

Section: Probioticsmentioning

confidence: 99%

Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents

Sainsbury

Ford

2010

Therap Adv Gastroenterol

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Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract of unknown etiology. The diagnosis of IBS is made clinically, using symptom-based criteria such as the Manning or Rome criteria. Medical therapy for this condition has traditionally been directed towards symptom relief, using fiber or antispasmodic agents. In recent years, emerging data have confirmed the efficacy of antidepressants, psychological therapies, 5-HT 3 antagonists, 5-HT 4 agonists, and probiotics in the short-term treatment of IBS, although whether these therapies influence the long-term course of the disease is unknown. Increasing knowledge regarding the pathophysiological mechanisms underlying IBS has resulted in a number of novel molecular treatments, which show promise. These include therapies targeting gastrointestinal mucosal chloride channels and guanylate cyclase-C receptors, as well as highly selective agents influencing serotonergic transmission that, at the time of writing, do not appear to have any severe deleterious effects. In this article we provide a summary of current and emerging therapies in this field.

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“…Yet the effects on intrinsic enteric neurons are largely unexplored. Feeding with certain bacterial species and strains reduces the perception of visceral pain [3][4][5][6] , decreases activity in spinal single afferent fibres 4 and inhibits colorectal distension induced sensitization of dorsal root ganglion neurons 7 . Ingestion of a Lactobacillus rhamnosus strain, 'JB-1', (ref.…”

mentioning

confidence: 99%

Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons

et al. 2013

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Symbionts or probiotics are known to affect the nervous system. To understand the mechanisms involved, it is important to measure sensory neuron responses and identify molecules responsible for this interaction. Here we test the effects of adding Lactobacillus rhamnosus (JB-1) and Bacteroides fragilis to the epithelium while making voltage recordings from intestinal primary afferent neurons. Sensory responses are recorded within 8 s of applying JB-1 and excitability facilitated within 15 min. Bacteroides fragilis produces similar results, as does its isolated, capsular exopolysaccharide, polysaccharide A. Lipopolysaccharide-free polysaccharide A completely mimics the neuronal effects of the parent organism. Experiments with a mutant Bacteroides fragilis devoid of polysaccharide A shows that polysaccharide A is necessary and sufficient for the neuronal effects. Complex carbohydrates have not been reported before as candidates for such signalling between symbionts and the host. These observations indicate new neuronal targets and invite further study of bacterial carbohydrates as inter-kingdom signalling molecules between beneficial bacteria and sensory neurons.

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Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice

Cited by 399 publications

References 36 publications

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome

Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents

Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons

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