Specific protein methylation defects and gene expression perturbations in  coactivator-associated arginine methyltransferase 1-deficient mice

Yadav, Neelu; Lee, Jae-Ho; Kim, Jeesun; Shen, Jianjun; Hu, Mickey C.T.; Aldaz, C. Marcelo; Bedford, Mark T.

doi:10.1073/pnas.1232272100

Cited by 261 publications

(297 citation statements)

References 38 publications

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“…47 CARM1 is a coactivator with Arginine Methyltransferase enzymatic activity, shown to be involved in the activation of the GADD45 gene by p53, 48 as well as activation by Estrogens. 49 In the C2C12 muscle differentiation system, CARM1 plays a crucial role, as RNAi inactivation leads to impairment of myotubes formation, by downregulation of key muscle transcription factors Myogenin and MEF2. 50 A similar scenario could be envisaged for keratinocyte differentiation and p63.…”

Section: Discussionmentioning

confidence: 99%

Identification of New p63 Targets in Human Keratinocytes

Testoni¹,

Borrelli²,

Tenedini³

et al. 2006

Cell Cycle

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ABSTRACTp63 is a transcription factor involved in the development of ectodermal tissues, including limb, skin and, in general, multilayered epithelia. We identified both activated and repressed genes in human keratinocytes via gene expression profiling of p63-depleted cells and validated 21 new primary targets by RT-PCR and ChIP location analysis. The p63 isoforms differentially activate or repress selected promoters. ChIPs in primary keratinocytes indicate that p63 targets are generally shared with p53, but some are p63-specific. Several growth suppressors are among repressed genes. The newly identified genes belong to pathways of growth and differentiation and are regulated in HaCaT differentiation and in stratification of human skin.

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Section: Discussionmentioning

confidence: 99%

Identification of New p63 Targets in Human Keratinocytes

Testoni¹,

Borrelli²,

Tenedini³

et al. 2006

Cell Cycle

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“…When and how is differential histone modification (H3R17me2 and H3R26me2) generated among blastomeres? If Carm1 is the only enzyme that methylates arginine residues, we need to know its expression pattern [15]. However, Carm1 may function as a maternal factor, so it will be interesting to characterize embryos of maternal Carm1 knockout mice.…”

Section: Epigenetic Differences Among Earlymentioning

confidence: 99%

Origin of cellular asymmetries in the pre-implantation mouse embryo: a hypothesis

Takaoka

Hamada

2014

Phil. Trans. R. Soc. B

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The first cell fate decision during mouse development concerns whether a blastomere will contribute to the inner cell mass (ICM; which gives rise to the embryo proper) or to trophectoderm (TE; which gives rise to the placenta). The position of a cell within an 8-to 16-cell-stage embryo correlates with its future fate, with outer cells contributing to TE and inner cells to the ICM. It remains unknown, however, whether an earlier pre-pattern exists. Here, we propose a hypothesis that could account for generation of such a prepattern and which is based on epigenetic asymmetry (such as in histone or DNA methylation) between maternal and paternal genomes in the zygote.

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“…MEFs isolated from PRMT4 À/À 12.5 days embryos do not exhibit any methylation of PRMT4 substrates such as PABP1, p300, and histone H3R17. Moreover, PRMT4 À/À MEFs are defective in activation of estrogen responsive genes (Yadav et al, 2003). PRMT4 has also been shown to be required for normal T cell development and muscle differentiation (Chen et al, 2002;Kim et al, 2004).…”

Section: Protein Arginine Methyltransferasesmentioning

confidence: 99%

Interplay between chromatin remodelers and protein arginine methyltransferases

Pal

Sif

2007

Journal Cellular Physiology

139

124

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Chromatin modifying enzymes have emerged as key regulators of all DNA based processes, which control cell growth, development, and differentiation. Recently, it has become clear that different chromatin remodeling and histone-modifying activities are involved in transcriptional activation and repression. Among the enzymes involved in regulating chromatin structure is the family of protein arginine methyltransferases (PRMTs) that specializes in methylating both histones as well as key cellular proteins. There are eleven different PRMT genes (PRMT1-11) whose biological function remains under explored. PRMTs regulate various cellular processes such as DNA repair and transcription, RNA processing, signal transduction, and nucleo-cytoplasmic localization. Like histone lysine methylation, methylation of histone arginine residues can either induce or inhibit transcription depending on the residue being modified and the type of methylation being introduced. In this review, we will focus on the latest findings and biological roles of ATP-dependent chromatin remodeling complexes and PRMT enzymes, and how their aberrant expression is linked to cancer.

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Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice

Cited by 261 publications

References 38 publications

Identification of New p63 Targets in Human Keratinocytes

Identification of New p63 Targets in Human Keratinocytes

Origin of cellular asymmetries in the pre-implantation mouse embryo: a hypothesis

Interplay between chromatin remodelers and protein arginine methyltransferases

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