Specific Reactions of Polyelectrolytes with the Surfaces of Normal and Tumour Cells

Studies on the Function of the Kurloff Cell

“…We have found that clumping of macrophages occurs only after cell damage is manifest, and that chondroitin sulphate and heparin neither damage nor clump these cells. Ambrose, Easty and J ones [2] have demon strated that suspensions of spleen cells did not exhibit clumping in the presence of the negatively-charged mucopolysaccharide heparin.…”

Heparin, dextran 1000 and metastasis formation after I.V. tumour cell injection in dextran non-sensitive rats

“…Heparin is a potent surfactant. It is known that heparin can alter membrane functions and cellular volume (Ambrose, 1967), electrophoretic mobility, adhesiveness and possibly the deformation of cells (Nordling, 1967), ability of cells to aggregate (Ambrose, Easty and Jones, 1968) and contact between lymphocytes and target cells (Taylor and Culling, 1966). Such changes might lead to decreased lodgement of tumour cells in the pulmonary circulation.…”

Non-viral cancer gene therapy: Beyond delivery

“…Actually polycations including PEI and PPI have been known to have intrinisic anti-tumour effects for a long time. [4][5][6] Previous data 6 as well as this new study 1 Whereas it seems likely that cationic polymers stimulate the immune system and might also have a direct anti-tumour effect, 8,9 their exact mechanism of anti-tumour activity remains largely unknown. Recent developments in proteomics and transcriptomics might allow a more detailed insight.…”