Specific sequences of fibronectin activate the protein kinase C signal transduction pathway in invasive bladder cancer

Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration

“…For example, our studies demonstrated that fibronectin-dependent migration of bladder cancer cells is associated with the ecosanoid and Wnt/β-Catenin signaling pathways while fibronectin was reported to stimulate the motility of invasive human bladder cancer T24 cells via PKC signal transduction pathways (Margolis et al , 1996). By virtue of using 40 cell lines and querying which genes associate with migration on all surfaces, this approach may identify gene products and signaling pathways that are generally relevant in human bladder cancer rather than being limited to specific matrix models.…”

PKC-dependent phosphorylation of p27 at T198 contributes to p27 stabilization and cell cycle arrest

“…For example, overexpression of some PKCs has been demonstrated in tissue samples of prostate, endometrial, high-grade urinary bladder and hepatocellular cancers, [46][47][48][49] while PKCα, βΙ, δ and ζ have been shown to be decreased at different stages of neoplastic progression. [50][51][52][53][54][55][56] It is of particular interest that in rat intestinal epithelial crypt cells, PKC signaling, and in particular PKCα, mediates cell cycle exit through rapid downregulation of G 1 cyclins and increased expression of Cip/Kip cyclin-dependent kinase inhibitors.…”

Fibronectin Promotes Tyrosine Phosphorylation of Paxillin and Cell Invasiveness in the Gastric Cancer Cell Line AGS

“…Recent findings have suggested that fibronectin has a stimulatory effect on the migration and proliferation of tumor cells. Researchers have also found that fibronectin can promote migration and progression of invasive human bladder cancer 14 , ovarian cancer 15 and glioblastoma cells 16 . Novel methods of suppressing cell migration have been shown to be connected to the fibronectin signaling pathway; for example, intravesical bacillus Calmette-Guerin (BCG) therapy against human bladder cancer migration produces its effect through inhibition of fibronectin function 17 .…”