Specific tonotopic organizations of different areas of the human auditory cortex revealed by simultaneous magnetic and electric recordings

Pantev, Christo; Bertrand, Olivier; Eulitz, Carsten; Verkindt, Chantal; Hampson, S.; Schuierer, Gerhard; Elbert, Thomas

doi:10.1016/0013-4694(94)00209-4

Cited by 414 publications

(292 citation statements)

References 54 publications

Supporting

Mentioning

240

Contrasting

Unclassified

Order By: Relevance

“…Because of intrinsic limitations in MEG spatial resolution, MEG probably will not be able to provide substantial insight into which of these mechanisms, if any, may contribute to the observed deficit. However, there are components in the auditory evoked magnetic field that are generated by primary auditory cortex (Lutkenhoner et al, 2003, Pantev et al, 1995, Yvert et al, 2001. A future study focusing on such signals could therefore examine population frequency tuning of units that are more likely to have sharper tuning curves, at least in healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Rojas

Slason

Teale

et al. 2007

Schizophrenia Research

View full text Add to dashboard Cite

Deficits in basic auditory perception have been described in schizophrenia. Previous electrophysiological imaging research has documented a structure-function disassociation in the auditory system and altered tonotopic mapping in schizophrenia. The present study examined auditory cortical tuning in patients with schizophrenia.Eighteen patients with schizophrenia and 15 comparison subjects were recorded in a magnetoencephalographic (MEG) experiment of auditory tuning. Auditory cortical tuning at 1 kHz was examined by delivering 1 kHz pure tones in conjunction with pure tones at 5 frequencies surrounding and including 1 kHz. Source reconstruction data were examined for evidence of frequency specificity for the M100 component.There was a significant broadening of tuning in the schizophrenia group evident for the source amplitude of the M100. The frequently reported reduction in anterior-posterior source asymmetry for individuals with schizophrenia was replicated in this experiment. No relationships between symptom severity ratings and MEG measures were observed.This finding suggests that the frequency specificity of the M100 auditory evoked field is disturbed in schizophrenia, and may help explain the relatively poor behavioral performance of schizophrenia patients on simple frequency discrimination tasks. KeywordsMagnetoencephalography; Evoked Potentials; Auditory Cortex; Mental Illness; N100; M100 Corresponding Author: Donald C. Rojas, Ph.D. Box C268−68 CPH Rm 2J10 4200 E. 9th Avenue Denver, CO 80262 Phone: (303) 315 −8624 FAX: (303) 315−5641 email: Don.Rojas@uchsc.edu. Contributors D.C.R designed the study, performed the statistical analysis and wrote the manuscript. E.S. contributed data analyses and preliminary statistical analyses. P.D.T. contributed to the design of the experiment and selection of data analytic strategies and M.L.R. had substantial input on clinical aspects of the design, including selection and implementation of schizophrenia diagnostic and clinical measures appearing in the paper. All authors have contributed to and approved the final manuscript.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conflict of InterestAll authors declare that they have no conflicts of interest with respect to this manuscript. NIH Public Access IntroductionThe M100 auditory evoked field has been reported to show anomalous anterior-posteior source location asymmetry in actively psychotic patients with paranoid schizophrenia. In normal adults, the neuroanatomical source of the M100 component is further anterior in the right hemisphere (Baumann et al., 1991). We and ...

show abstract

Section: Discussionmentioning

confidence: 99%

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Rojas

Slason

Teale

et al. 2007

Schizophrenia Research

View full text Add to dashboard Cite

show abstract

“…Electrophysiological, neuromagnetic, and fMRI studies of auditory cortex in humans have shown that frequency sensitivity is bilaterally localized on the supratemporal plane, with low frequencies more lateral and anterior than high frequencies (Pantev et al, 1988(Pantev et al, , 1995Verkindt et al, 1995). However, some studies failed to find tonotopic mapping of N 100 and its magnetic counterpart N 100m and reported other factors, such as latency, to be important (Roberts and Poeppel, 1996;Stufflebeam et al, 1998;Lutkenhoner et al, 2003).…”

Section: Frequency Mapping In the Auditory Systemmentioning

confidence: 99%

Auditory-evoked potentials to frequency increase and decrease of high- and low-frequency tones

Pratt

Starr

Michalewski

et al. 2009

Clinical Neurophysiology

View full text Add to dashboard Cite

a b s t r a c tObjective: To define cortical brain responses to large and small frequency changes (increase and decrease) of high-and low-frequency tones. Methods: Event-Related Potentials (ERPs) were recorded in response to a 10% or a 50% frequency increase from 250 or 4000 Hz tones that were approximately 3 s in duration and presented at 500-ms intervals. Frequency increase was followed after 1 s by a decrease back to base frequency. Frequency changes occurred at least 1 s before or after tone onset or offset, respectively. Subjects were not attending to the stimuli. Latency, amplitude and source current density estimates of ERPs were compared across frequency changes. Results: All frequency changes evoked components P 50 , N 100 , and P 200 . N 100 and P 200 had double peaks at bilateral and right temporal sites, respectively. These components were followed by a slow negativity (SN). The constituents of N 100 were predominantly localized to temporo-parietal auditory areas. The potentials and their intracranial distributions were affected by both base frequency (larger potentials to low frequency) and direction of change (larger potentials to increase than decrease), as well as by change magnitude (larger potentials to larger change). The differences between frequency increase and decrease depended on base frequency (smaller difference to high frequency) and were localized to frontal areas. Conclusions: Brain activity varies according to frequency change direction and magnitude as well as base frequency. Significance: The effects of base frequency and direction of change may reflect brain networks involved in more complex processing such as speech that are differentially sensitive to frequency modulations of high (consonant discrimination) and low (vowels and prosody) frequencies.

show abstract

“…Several studies have suggested that N1m originates from HeschlÕs Gyrus (Elberling et al, 1982;Reite et al, 1994); but the secondary auditory areas in the supratemporal plane are another possibility (Pantev et al, 1995;Lütkenhö ner and Steinsträter, 1998). It would be useful to compare the location of these activation sites with cyto-architectonic data in order to assess whether frequency-dependent activated areas are located in the same physiologically defined field, which would reflect tonotopy, or in separate fields, which would not point to any tonotopic organization (Schö nwiesner et al, 2002).…”

Section: Tonotopic Organization Of the Auditory Cortexmentioning

confidence: 99%

Effect of stimulus frequency and stimulation site on the N1m response of the human auditory cortex

et al. 2004

View full text Add to dashboard Cite

The aim of the present study was to investigate the functional organization of the auditory cortex for pure tones of 1, 2, 4, 6, 8 and 12 kHz. Ten subjects were tested with a whole-head magnetometer (151 channels). The location, latency and amplitude of the generators of the N1m (the main component of the response, peaking approximately at 100 ms) were explored simultaneously in the right and left hemispheres under monaural stimulation. Our results revealed that tonotopy is a rather complex functional organization of the auditory cortex. From 1 to 12 kHz, tonotopic maps were found for contralateral as well as for ipsilateral stimulation: N1m generators were found to be tonotopically organized mainly in an anterior-posterior direction in both hemispheres, whatever the stimulated ear, but also in an inferior-superior direction in the right hemisphere. Furthermore, latencies were longer in the left than in the right hemisphere. Two different representations of spectral distribution were found in the right auditory cortex: one for ipsilateral and one for contralateral stimulation.

show abstract

Specific tonotopic organizations of different areas of the human auditory cortex revealed by simultaneous magnetic and electric recordings

Cited by 414 publications

References 54 publications

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Auditory-evoked potentials to frequency increase and decrease of high- and low-frequency tones

Effect of stimulus frequency and stimulation site on the N1m response of the human auditory cortex

Contact Info

Product

Resources

About