Specification of sensory placode progenitors: signals and transcription factor networks

Streit, Andrea

doi:10.1387/ijdb.170298as

Cited by 24 publications

(21 citation statements)

References 112 publications

(209 reference statements)

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“…The NC cells are morphologically distinguishable at the late neurulation stage when they delaminate and migrate away from the edge of the neuroectoderm, towards the final locations where they differentiate (Shellard and Mayor, 2019;Alkobtawi and Monsoro-Burq, 2020;Thiery et al, 2020). In parallel, during neurulation, the pan-placodal ectoderm is subdivided into thickened epithelial areas defining each placode, which contribute to cranial sensory structures (Schlosser, 2008(Schlosser, , 2010Pieper et al, 2011;Grocott el al., 2012;Streit, 2018;Buzzi et al, 2019). Lineage tracing studies have detailed the respective contributions of the NC and the placodes (Noden, 1975;Keller, 1976;Le Douarin, 1980;D' Amico-Martel and Noden, 1983;Le Douarin, 1985, 1987;Eagleson and Harris, 1990;Garcia-Martinez and Schoenwolf, 1993;Eagleson et al, 1995;Kozlowski et al, 1997;Streit, 2002;Bhattacharya et al, 2004;Xu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Insights Into the Early Gene Regulatory Network Controlling Neural Crest and Placode Fate Choices at the Neural Border

Seal

Monsoro-Burq

2020

Front. Physiol.

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The neural crest (NC) cells and cranial placodes are two ectoderm-derived innovations in vertebrates that led to the acquisition of a complex head structure required for a predatory lifestyle. They both originate from the neural border (NB), a portion of the ectoderm located between the neural plate (NP), and the lateral non-neural ectoderm. The NC gives rise to a vast array of tissues and cell types such as peripheral neurons and glial cells, melanocytes, secretory cells, and cranial skeletal and connective cells. Together with cells derived from the cranial placodes, which contribute to sensory organs in the head, the NC also forms the cranial sensory ganglia. Multiple in vivo studies in different model systems have uncovered the signaling pathways and genetic factors that govern the positioning, development, and differentiation of these tissues. In this literature review, we give an overview of NC and placode development, focusing on the early gene regulatory network that controls the formation of the NB during early embryonic stages, and later dictates the choice between the NC and placode progenitor fates.

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Section: Introductionmentioning

confidence: 99%

Insights Into the Early Gene Regulatory Network Controlling Neural Crest and Placode Fate Choices at the Neural Border

Seal

Monsoro-Burq

2020

Front. Physiol.

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“…The Six1 homeodomain containing transcription factor plays a key role in vertebrate cranial placode development [15][16][17][18][19]. Loss-of-function by knock-down of endogenous protein or by genetic deletion results in reduced expression of placode genes and a variety of defects during otic development spanning otic placode formation to sensory hair cell differentiation [20][21][22][23][24][25][26][27][28][29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Mutations in SIX1 associated with Branchio-oto-renal Syndrome (BOR) differentially affect otic expression of putative target genes

Mehdizadeh

Majumdar

Ahsan

et al. 2021

Preprint

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Single nucleotide mutations in SIX1 are causative in some individuals diagnosed with branchiootic/branchio-oto-renal (BOR) syndrome. To test whether these mutations have differential effects on otic gene expression, we engineered four BOR mutations in Xenopus six1 and targeted mutant protein expression to the neural crest and cranial placode precursor cells in wild-type embryos. Changes in the otic expression of putative Six1 targets and/or co-factors were monitored by qRT-PCR and in situ hybridization. We found that each mutant had a different combination of effects. The V17E mutant reduced eya2, tspan13, zbtb16 and pa2g4 otic vesicle expression at a frequency indistinguishable from wildtype Six1, but reduced prdm1 more and spry1 less compared to wild-type Six1. For most of these genes, the R110W, W122R and Y129C mutants were significantly less repressive compared to wild-type Six1. Their individual effects varied according to the level at which they were expressed. The R110W, W122R and Y129C mutants also often expanded prdm1 otic expression. Since previous studies showed that all four mutants are transcriptionally deficient and differ in their ability to interact with co-factors such as Eya1, we propose that altered co-factor interactions at the mutated sites differentially interfere with their ability to drive otic gene expression.

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“…Another key difference is that whereas EMT and migration are a sine qua non of neural crest development, placodes may instead simply invaginate (e.g., lens, adenohypophyseal, and otic placodes) without migrating far from their site of origin ( Schlosser, 2002 , 2006 , 2010 ). Finally, although they develop as adjacent cell populations in the ectoderm, neural crest and placodes in most jawed vertebrates, with a few notable exceptions, have relatively divergent GRNs that orchestrate their development, even though they likely share a common evolutionary origin ( Grocott et al, 2012 ; Moody and LaMantia, 2015 ; Riddiford and Schlosser, 2016 ; Maharana et al, 2017 ; Martik and Bronner, 2017 ; Plouhinec et al, 2017 ; Horie et al, 2018 ; Maharana and Schlosser, 2018 ; Streit, 2018 ).…”

Section: Interactions Of Neural Crest and Placodes In The Jawed Vertementioning

confidence: 99%

Evolutionary and Developmental Associations of Neural Crest and Placodes in the Vertebrate Head: Insights From Jawless Vertebrates

2020

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Neural crest and placodes are key innovations of the vertebrate clade. These cells arise within the dorsal ectoderm of all vertebrate embryos and have the developmental potential to form many of the morphological novelties within the vertebrate head. Each cell population has its own distinct developmental features and generates unique cell types. However, it is essential that neural crest and placodes associate together throughout embryonic development to coordinate the emergence of several features in the head, including almost all of the cranial peripheral sensory nervous system and organs of special sense. Despite the significance of this developmental feat, its evolutionary origins have remained unclear, owing largely to the fact that there has been little comparative (evolutionary) work done on this topic between the jawed vertebrates and cyclostomes-the jawless lampreys and hagfishes. In this review, we briefly summarize the developmental mechanisms and genetics of neural crest and placodes in both jawed and jawless vertebrates. We then discuss recent studies on the role of neural crest and placodes-and their developmental association-in the head of lamprey embryos, and how comparisons with jawed vertebrates can provide insights into the causes and consequences of this event in early vertebrate evolution.

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Specification of sensory placode progenitors: signals and transcription factor networks

Cited by 24 publications

References 112 publications

Insights Into the Early Gene Regulatory Network Controlling Neural Crest and Placode Fate Choices at the Neural Border

Insights Into the Early Gene Regulatory Network Controlling Neural Crest and Placode Fate Choices at the Neural Border

Mutations in SIX1 associated with Branchio-oto-renal Syndrome (BOR) differentially affect otic expression of putative target genes

Evolutionary and Developmental Associations of Neural Crest and Placodes in the Vertebrate Head: Insights From Jawless Vertebrates

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