Specificity of B-Type Natriuretic Peptide Assays: Cross-Reactivity with Different BNP, NT-proBNP, and proBNP Peptides

Saenger, Amy K.; Rodríguez-Fraga, Olaia; Ler, Ranka; Ordóñez-Llanos, Jordi; Jaffe, Allan S.; Goetze, Jens P.; Apple, Fred S.

doi:10.1373/clinchem.2016.263749

Cited by 65 publications

(48 citation statements)

References 27 publications

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“…demonstrated cross-reactivity with proBNP and NT-proBNP in different BNP types [18]. In the present study, different contrast medias led to false negative results in NT-proBNP tests ranging from 6.11% to 96.01%.…”

Section: Discussionsupporting

confidence: 47%

How Does Contrast Media Affect Cardiac Markers and Coagulation Tests? Experimental Study

Taşçanov¹,

Gönel²

2019

Preprint

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Background and objectives: The fact that the results of troponin and Nt-proBNP interfere from biotin caused some commercial firms to update their measurement methods. In particular, the clinical incompatibility of cardiac test results may affect the risk of morbidity and mortality. The aim of this study is to investigate the interference effects of 7 different contrast agents on cardiac markers (Troponin-I, Nt-proBNP, Mass CK-MB, CK, AST, LDH) and coagulation tests (PT, APTT). Materials and Methods: Seven different contrast medias were added into control materials by using interference protocol. Concentration of PT, APTT, CK, AST, LDH, Mass CK-MB, Troponin-I, Nt-proBNP were measured by Sysmex CS-2100, Abbott c16000, Siemens Centaur XP and AFİAS-6 analyzer. The amount of deviations from target values were calculated. Results: 7 different contrast medias caused negative interference in troponin levels between 57.43% and 62.87%. It was found that different contrast medias produced false negativity in the pro-BNP test ranging from 6.11% to 96.01%. Enzymes and coagulation tests have been less affected. Conclusions: Different contrast medias may cause false negative cTnI and pro-BNP. Therefore, the contrast medias which causes the least interference should be preferred. The results of samples taken in the first hour of contrast imaging should be interpreted with care.

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Section: Discussionsupporting

confidence: 47%

How Does Contrast Media Affect Cardiac Markers and Coagulation Tests? Experimental Study

Taşçanov¹,

Gönel²

2019

Preprint

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“…This assay cross-reacts with proBNP to a similar degree as current diagnostic assays such as the Abbott BNP (19,28 ).…”

Section: In-house Total-bnp Luminexmentioning

confidence: 89%

Development of a BNP1-32 Immunoassay That Does Not Cross-React with proBNP

et al. 2017

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“…NT-proBNP is secreted in response to increased myocardial wall stress [13]. It is also controlled by acute renal injury and proinflammatory molecules such as lipopolysaccharide, interleukin 1, C-reactive protein, and cardiotrophin I, which are independent of ventricular function [14,15].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of NT-proBNP in patients with severe COVID-19

et al. 2020

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Background: The outbreak of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown. Methods: The study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records.Results: The best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (≤88.64 pg/mL). After adjustment for potential risk factors, NT-proBNP was independently correlated with in-hospital death. Conclusion: NT-proBNP might be an independent risk factor for in-hospital death in patients with severe COVID-19.

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Specificity of B-Type Natriuretic Peptide Assays: Cross-Reactivity with Different BNP, NT-proBNP, and proBNP Peptides

Cited by 65 publications

References 27 publications

How Does Contrast Media Affect Cardiac Markers and Coagulation Tests? Experimental Study

How Does Contrast Media Affect Cardiac Markers and Coagulation Tests? Experimental Study

Development of a BNP1-32 Immunoassay That Does Not Cross-React with proBNP

Prognostic value of NT-proBNP in patients with severe COVID-19

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