Specificity of Delayed Cutaneous Hypersensitivity Reactions to Extracts of Human Tumor Cells2

Weese, James L.; Herberman, Ronald B.; Hollinshead, Ariel C.; Cannon, Grace B.; Keels, Marian; Kibrite, Antoine; Morales, Alvaro; Char, Devron H.; Oldham, Robert K.

doi:10.1093/jnci/60.2.255

Cited by 24 publications

(9 citation statements)

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“…Skin tests were considered positive when a reaction of induration of 5 mm or more was present after 48 h. Hypotonic membrane extracts prepared by the method of Oren and Herberman (1971) were also utilized in skin tests to evaluate antigens more closely related to cancer. Preparation 2937, obtained from a metastatic breast tumor which appeared to contain tumor-associated antigens in previous skin tests (Weese et al, 1978), was used. Additional antigens were obtained from established cell lines derived from breast tumors in order to obtain more reproducible antigens that could be used in larger numbers of patients.…”

Section: Methodsmentioning

confidence: 99%

Rapidly progressing breast cancer (poussée Évolutive) in Tunisia: Studies on delayed hypersensitivity

Mourali

Levine

Tabanne

et al. 1978

Intl Journal of Cancer

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Delayed hypersensitivity reactions to a battery of antigens were measured in 145 Tunisian breast cancer patients to determine whether an immunologic mechanism could be detected which might explain the high frequency (60%) of the rapidly progressing form in Tunisian breast cancer patients. Although a greater proportion (30%) of patients with rapily progressing breast cancer reacted to extracts of a breast tumor antigen (2937) than patients without PEV (9%), no significnat difference between PEV and non-PEV patients could be found in reactivity to DNCB, standard microbial antigens, or extracts from tissue culture cell lines. Rapidly progressing breast cancer in Tunisia is not associated with an impairment of delayed hypersensitivity.

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Section: Methodsmentioning

confidence: 99%

Rapidly progressing breast cancer (poussée Évolutive) in Tunisia: Studies on delayed hypersensitivity

Mourali

Levine

Tabanne

et al. 1978

Intl Journal of Cancer

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“…The sensitivity and specificity of skin-test responses to autologous and allogeneic tumor cell extracts vary in different studies with the method of preparation and the protein content [7,14,16,21]. Nonspecific reactivity of crude extracts appeared to be less frequent when the protein content of crude cell extracts were between 100 and 200 ~tg per test dose.…”

Section: Discussionmentioning

confidence: 99%

“…In vivo cell-mediated immunity to human tumors has been examined by means of delayed hypersensitivity skin reactions (DHSR) to either crude membrane preparations or soluble extracts of tumor cells [7,14,16,21]. The safety of this procedure has been demonstrated in extensive studies performed on many patients.…”

Section: Introductionmentioning

confidence: 99%

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Virus-augmented delayed hypersensitivity skin tests in gynecological malignancies

Freedman

Bowen

Atkinson

et al. 1984

Cancer Immunol Immunother

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Cultured human tumor cells of various histologic origins were infected with PR8/A/34 influenza virus. Nonviable crude membrane extracts were derived from the infected and uninfected cells. The extracts were coded and tested for their ability to produce delayed hypersensitivity skin reactions (DHSR) in allogeneic patients with squamous uterine cervical carcinoma, epithelial ovarian carcinoma, and malignant melanoma. Augmented antigen sensitivity to the virus-modified extracts compared with virus alone or to the unmodified extracts was observed in all patient groups. There was insufficient specificity to delineate a response by individual tumor type and related tumor extract, but some of the observed responses suggested tumor or organ site associations. Cervical carcinoma patients reacted more frequently to the virus-modified cervix extract, which also produced a high frequency of response in patients with ovarian carcinoma and melanoma. Ovarian carcinoma patients demonstrated increased sensitivity to both virus-modified ovarian carcinoma extracts, although 14 of 21 patients also showed responsiveness to one of the unmodified ovarian extracts. Malignant melanoma patients showed increased sensitivity to all virus-modified extracts except one of two derived from the ovarian carcinoma, and demonstrated a significantly augmented response to the virus-modified melanoma extract when the response to this extract was compared with that in ovarian carcinoma patients. The augmented reactions appear to be due to an association of the PR8 virus and as yet undetermined cellular components rather than to the virus alone. The possible involvement of tumor-associated determinants and the clinical significance of this phenomenon require further investigation.

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“…18 However, the value of such tests may be altered by malignancy-induced anergy that affects all delayed hypersensitivity tests.…”

Section: Immune Response To Malignant Tumorsmentioning

confidence: 99%

Immune Responses to Malignancy: An Overview

Harfi

1982

Ann Saudi Med

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Specificity of Delayed Cutaneous Hypersensitivity Reactions to Extracts of Human Tumor Cells2

Cited by 24 publications

References 0 publications

Rapidly progressing breast cancer (poussée Évolutive) in Tunisia: Studies on delayed hypersensitivity

Rapidly progressing breast cancer (poussée Évolutive) in Tunisia: Studies on delayed hypersensitivity

Virus-augmented delayed hypersensitivity skin tests in gynecological malignancies

Immune Responses to Malignancy: An Overview

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